Interactor 1: R1A (P0C6U8)
Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Host translation inhibitor nsp1 (Leader protein) (Non-structural protein 1) (nsp1); Non-structural protein 2 (nsp2) (p65 homolog); Papain-like protease nsp3 (PL-PRO) (EC 3.4.19.12) (EC 3.4.22.-) (Non-structural protein 3) (nsp3) (PL2-PRO); Non-structural protein 4 (nsp4); 3C-like proteinase nsp5 (3CL-PRO) (3CLp) (EC 3.4.22.69) (Main protease) (Mpro) (Non-structural protein 5) (nsp5) (SARS coronavirus main proteinase); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); RNA-capping enzyme subunit nsp9 (Non-structural protein 9) (nsp9) (EC 2.7.7.50); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
Gene: 1a
Interactor 2: R1A (P0C6U8)
Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Host translation inhibitor nsp1 (Leader protein) (Non-structural protein 1) (nsp1); Non-structural protein 2 (nsp2) (p65 homolog); Papain-like protease nsp3 (PL-PRO) (EC 3.4.19.12) (EC 3.4.22.-) (Non-structural protein 3) (nsp3) (PL2-PRO); Non-structural protein 4 (nsp4); 3C-like proteinase nsp5 (3CL-PRO) (3CLp) (EC 3.4.22.69) (Main protease) (Mpro) (Non-structural protein 5) (nsp5) (SARS coronavirus main proteinase); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); RNA-capping enzyme subunit nsp9 (Non-structural protein 9) (nsp9) (EC 2.7.7.50); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
Gene: 1a
Species: Severe acute respiratory syndrome-related coronavirus
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.970 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 16228002, 14962394, 25197083, 22039154, 27799534, 19153232, 18694760 |
| Identification Methods | x-ray crystallography, pull down, enzymatic study, protease assay, molecular sieving, light scattering, cross-linking study |
| Interaction Type | association, direct interaction, protein cleavage |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | bCoV_NAB~bCoV_NAB, Macro~bCoV_NSP3_N, CoV_NSP10~CoV_NSP10, CoV_NSP2_N~CoV_NSP2_N, CoV_NSP3_C~CoV_NSP3_C, CoV_NSP4_C~CoV_NSP4_C, CoV_NSP7~CoV_NSP7, CoV_NSP7~CoV_NSP8, CoV_NSP8~CoV_NSP8, CoV_NSP9~CoV_NSP9, CoV_peptidase~CoV_peptidase, Macro~Macro, Peptidase_C30~Peptidase_C30 |
| Common GO terms | GO:0002151 - G-quadruplex RNA binding GO:0003727 - single-stranded RNA binding GO:0003968 - RNA-dependent RNA polymerase activity GO:0004197 - cysteine-type endopeptidase activity GO:0004519 - endonuclease activity and 24 others more... |
| Homologous interactions | 5 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
