Protein: PRP19
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase PRP19)

Gene: PRP19
Organism: Saccharomyces cerevisiae S288C
Interactions: 165
UniProt ID: P32523

Gene Ontology (top 5):
GO:0000349 - generation of catalytic spliceosome for first transesterification step
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

739194

CEF1
Pre-mRNA-splicing factor CEF1

19

9

Small-scale

0.989

High

739114

PRP19
Pre-mRNA-processing factor 19

8

17

Small-scale

0.968

High

739222

CLF1
Pre-mRNA-splicing factor CLF1

14

20

Small-scale

0.762

High

739218

CWC2
Pre-mRNA-splicing factor CWC2

11

4

Small-scale

0.761

High

739198

SYF1
Pre-mRNA-splicing factor SYF1

12

19

Small-scale

0.760

High

638051

ISY1
Pre-mRNA-splicing factor ISY1

12

3

Small-scale

0.758

High

702234

YJU2
Splicing factor YJU2

7

4

Small-scale

0.749

High

739226

PRP46
Pre-mRNA-splicing factor PRP46

7

19

Small-scale

0.744

High

739154

PRP17
Pre-mRNA-processing factor 17

6

18

High-throughput

0.739

High

739204

SN309
Pre-mRNA-splicing factor SNT309

16

0

Small-scale

0.733

High

739216

RU2A
U2 small nuclear ribonucleoprotein A'

6

11

Small-scale

0.729

High

739135

NTC20
Pre-mRNA-splicing factor NTC20

13

0

Small-scale

0.727

High

739173

SYF2
Pre-mRNA-splicing factor SYF2

7

0

Small-scale

0.718

High

700076

PRP45
Pre-mRNA-processing protein 45

5

6

Small-scale

0.714

High

739123

PRP8
Pre-mRNA-splicing factor 8

5

7

Small-scale

0.714

High

739133

SLT11
Pre-mRNA-splicing factor SLT11

5

3

Small-scale

0.714

High

739117

BRR2
Pre-mRNA-splicing helicase BRR2

5

20

Small-scale

0.712

High

739181

RUXF
Small nuclear ribonucleoprotein F

5

6

Small-scale

0.706

High

625075

PRP9
Pre-mRNA-splicing factor PRP9

4

3

Small-scale

0.691

High

739127

SN114
Pre-mRNA-splicing factor SNU114

4

6

Small-scale

0.691

High

739164

SF3B1
U2 snRNP component HSH155

4

20

Small-scale

0.691

High

664580

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

4

18

Small-scale

0.689

High

739174

CWC22
Pre-mRNA-splicing factor CWC22

4

4

High-throughput

0.687

High

739221

USB1
U6 snRNA phosphodiesterase 1

5

0

High-throughput

0.684

High

672042

BUD31
Pre-mRNA-splicing factor BUD31

4

3

Small-scale

0.683

High

739147

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

5

Small-scale

0.683

High

739150

RUXG
Small nuclear ribonucleoprotein G

4

10

Small-scale

0.673

High

739177

CWC25
Pre-mRNA-splicing factor CWC25

3

1

High-throughput

0.667

High

739170

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

3

15

Small-scale

0.660

High

739115

PRP21
Pre-mRNA-splicing factor PRP21

3

3

Small-scale

0.650

High

739151

IST3
U2 snRNP component IST3

3

13

Small-scale

0.650

High

739155

SMD3
Small nuclear ribonucleoprotein Sm D3

3

18

Small-scale

0.650

High

739187

SMD1
Small nuclear ribonucleoprotein Sm D1

3

3

Small-scale

0.650

High

739189

CUS1
Cold sensitive U2 snRNA suppressor 1

3

3

Small-scale

0.650

High

739200

RSE1
Pre-mRNA-splicing factor RSE1

3

11

Small-scale

0.650

High

739205

SMD2
Small nuclear ribonucleoprotein Sm D2

3

2

Small-scale

0.650

High

739211

PRP11
Pre-mRNA-splicing factor PRP11

3

2

Small-scale

0.650

High

628194

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

3

18

Small-scale

0.646

High

739215

NCBP2
Nuclear cap-binding protein subunit 2

3

8

High-throughput

0.640

High

739208

URN1
Pre-mRNA-splicing factor URN1

2

0

High-throughput

0.633

High

739188

SPP2
Pre-mRNA-splicing factor SPP2

3

0

Small-scale

0.632

High

739168

CWC23
Pre-mRNA-splicing factor CWC23

2

5

High-throughput

0.628

High

739193

CWC21
Pre-mRNA-splicing factor CWC21

3

0

High-throughput

0.616

High

523379

HSP71
Heat shock protein SSA1

3

17

Small-scale

0.611

High

739158

CWC26
Pre-mRNA-splicing factor CWC26

2

1

High-throughput

0.611

High

739175

CWC24
Pre-mRNA-splicing factor CWC24

2

4

High-throughput

0.611

High

739152

MSL1
U2 small nuclear ribonucleoprotein B''

2

20

Small-scale

0.601

High

739191

SLU7
Pre-mRNA-splicing factor SLU7

2

0

High-throughput

0.585

High

739195

CWC15
Pre-mRNA-splicing factor CWC15

2

0

High-throughput

0.585

High

594259

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

2

Small-scale

0.584

High

739126

NCBP1
Nuclear cap-binding protein complex subunit 1

2

1

High-throughput

0.584

High

739207

SP382
Pre-mRNA-splicing factor SPP382

2

0

Small-scale

0.576

High

627839

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

2

17

Small-scale

0.571

High

739129

NTR2
Pre-mRNA-splicing factor NTR2

2

1

Small-scale

0.571

High

739190

CWC27
Peptidyl-prolyl isomerase CWC27

2

4

High-throughput

0.571

High

739209

DIB1
Spliceosomal protein DIB1

2

1

Small-scale

0.571

High

739213

PML1
Pre-mRNA leakage protein 1

2

2

Small-scale

0.571

High

739227

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

2

3

Small-scale

0.571

High

739229

HSH49
Protein HSH49

2

5

Small-scale

0.571

High

721292

PSB7
Proteasome subunit beta type-7

1

5

Small-scale

0.552

High

394360

EF1A
Elongation factor 1-alpha

2

3

Small-scale

0.552

High

544191

SSB1
Ribosome-associated molecular chaperone SSB1

2

16

Small-scale

0.552

High

739116

RU1A
U1 small nuclear ribonucleoprotein A

2

0

Small-scale

0.547

High

721779

XPO1
Exportin-1

1

12

High-throughput

0.536

High

739136

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.513

High

662079

MPIP
M-phase inducer phosphatase

1

2

High-throughput

0.508

High

739120

UFD4
Ubiquitin fusion degradation protein 4

1

16

High-throughput

0.508

High

739231

UBA3
NEDD8-activating enzyme E1 catalytic subunit

1

2

High-throughput

0.508

High

509456

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

12

High-throughput

0.501

High

739214

ESA1
Histone acetyltransferase ESA1

1

5

Small-scale

0.501

High

472262

MSS18
Protein MSS18

1

0

High-throughput

0.493

High

739122

UBC6
Ubiquitin-conjugating enzyme E2 6

1

9

Small-scale

0.481

High

590183

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

19

High-throughput

0.479

High

643615

SNF2
Transcription regulatory protein SNF2

1

11

Small-scale

0.479

High

706524

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

709632

BMH1
Protein BMH1

1

6

High-throughput

0.479

High

738791

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.479

High

739137

RCK2
Serine/threonine-protein kinase RCK2

1

6

High-throughput

0.479

High

739186

NOP3
Serine/arginine

1

14

Small-scale

0.479

High

739201

SWR1
Helicase SWR1

1

10

Small-scale

0.479

High

739210

RDS3
Pre-mRNA-splicing factor RDS3

1

1

High-throughput

0.479

High

739220

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

739230

MEX67
mRNA export factor MEX67

1

5

High-throughput

0.479

High

734888

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

739119

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

739124

PRP18
Pre-mRNA-splicing factor 18

1

0

High-throughput

0.458

High

739128

MUD2
Splicing factor MUD2

1

0

Small-scale

0.458

High

739130

YK21
Uncharacterized protein YKR041W

1

0

High-throughput

0.458

High

739143

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

739153

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

739156

IES1
Ino eighty subunit 1

1

0

Small-scale

0.458

High

739169

SAP4
SIT4-associating protein SAP4

1

0

High-throughput

0.458

High

739171

EFM5
Protein-lysine N-methyltransferase EFM5

1

0

High-throughput

0.458

High

739179

FYV6
Protein FYV6

1

0

High-throughput

0.458

High

739219

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

739140

YHS2
MIP18 family protein YHR122W

1

2

High-throughput

0.457

High

359443

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

Small-scale

0.445

High

368628

PMG1
Phosphoglycerate mutase 1

1

1

Small-scale

0.445

High

392427

HSP82
ATP-dependent molecular chaperone HSP82

1

15

High-throughput

0.445

High

434932

RS3
Small ribosomal subunit protein uS3

1

5

Small-scale

0.445

High

435536

RS9B
Small ribosomal subunit protein uS4B

1

4

Small-scale

0.445

High

435850

RS13
Small ribosomal subunit protein uS15

1

4

Small-scale

0.445

High

441785

RS14A
Small ribosomal subunit protein uS11A

1

4

Small-scale

0.445

High

444461

DED1
ATP-dependent RNA helicase DED1

1

9

Small-scale

0.445

High

455387

RS19B
Small ribosomal subunit protein eS19B

1

3

Small-scale

0.445

High

488932

SWI6
Regulatory protein SWI6

1

12

Small-scale

0.445

High

512041

RS4A
Small ribosomal subunit protein eS4A

1

5

Small-scale

0.445

High

514115

RS16B
Small ribosomal subunit protein uS9B

1

8

Small-scale

0.445

High

514525

RS18A
Small ribosomal subunit protein uS13A

1

3

Small-scale

0.445

High

526195

HSP72
Heat shock protein SSA2

1

17

High-throughput

0.445

High

624984

PRP6
Pre-mRNA-splicing factor 6

1

18

Small-scale

0.445

High

645336

XRN1
5'-3' exoribonuclease 1

1

1

Small-scale

0.445

High

670479

SIS1
Protein SIS1

1

4

Small-scale

0.445

High

671506

SWI4
Regulatory protein SWI4

1

12

Small-scale

0.445

High

674490

RS2
Small ribosomal subunit protein uS5

1

4

Small-scale

0.445

High

678638

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

2

Small-scale

0.445

High

688848

RS5
Small ribosomal subunit protein uS7

1

5

Small-scale

0.445

High

689337

RS7A
Small ribosomal subunit protein eS7A

1

4

Small-scale

0.445

High

739118

RSSA1
Small ribosomal subunit protein uS2A

1

3

Small-scale

0.445

High

739121

PRP40
Pre-mRNA-processing protein PRP40

1

1

Small-scale

0.445

High

739125

RS3A1
Small ribosomal subunit protein eS1A

1

2

Small-scale

0.445

High

739131

GBLP
Small ribosomal subunit protein RACK1

1

18

Small-scale

0.445

High

739132

LSM2
LSM complex subunit LSM2

1

18

Small-scale

0.445

High

739138

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

5

Small-scale

0.445

High

739139

RS20
Small ribosomal subunit protein uS10

1

2

Small-scale

0.445

High

739142

DHH1
ATP-dependent RNA helicase DHH1

1

18

Small-scale

0.445

High

739144

MBP1
Transcription factor MBP1

1

15

Small-scale

0.445

High

739145

PRP39
Pre-mRNA-processing factor 39

1

19

Small-scale

0.445

High

739146

SNU13
13 kDa ribonucleoprotein-associated protein

1

8

Small-scale

0.445

High

739148

LSM4
LSM complex subunit LSM4

1

9

Small-scale

0.445

High

739149

SSB2
Ribosome-associated molecular chaperone SSB2

1

16

High-throughput

0.445

High

739157

SAD1
Pre-mRNA-splicing factor SAD1

1

13

Small-scale

0.445

High

739159

LSM1
LSM1-LSM7 complex subunit LSM1

1

15

Small-scale

0.445

High

739160

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.445

High

739161

LSM8
LSM2-LSM8 complex subunit LSM8

1

14

Small-scale

0.445

High

739162

RS12
Small ribosomal subunit protein eS12

1

2

Small-scale

0.445

High

739163

PRP31
Pre-mRNA-processing factor 31

1

6

Small-scale

0.445

High

739165

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

5

Small-scale

0.445

High

739166

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

5

Small-scale

0.445

High

739167

PFD6
Prefoldin subunit 6

1

6

High-throughput

0.445

High

739176

CUS2
Cold sensitive U2 snRNA suppressor 2

1

14

Small-scale

0.445

High

739178

LSM7
LSM complex subunit LSM7

1

15

Small-scale

0.445

High

739180

APJ1
J domain-containing protein APJ1

1

5

High-throughput

0.445

High

739182

LSM3
LSM complex subunit LSM3

1

17

Small-scale

0.445

High

739183

NAM8
Protein NAM8

1

4

Small-scale

0.445

High

739185

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

16

Small-scale

0.445

High

739192

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

1

3

Small-scale

0.445

High

739196

PRP42
U1 small nuclear ribonucleoprotein component PRP42

1

20

Small-scale

0.445

High

739206

LSM6
LSM complex subunit LSM6

1

6

Small-scale

0.445

High

739212

LUC7
Protein LUC7

1

4

Small-scale

0.445

High

739224

RUXE
Small nuclear ribonucleoprotein E

1

3

Small-scale

0.445

High

739134

SP381
Pre-mRNA-splicing factor SPP381

1

0

Small-scale

0.426

High

739172

SNU71
U1 small nuclear ribonucleoprotein component SNU71

1

0

Small-scale

0.426

High

739184

PRP38
Pre-mRNA-splicing factor 38

1

0

Small-scale

0.426

High

739197

SNU56
56 kDa U1 small nuclear ribonucleoprotein component

1

0

Small-scale

0.426

High

739202

NSE3
Non-structural maintenance of chromosome element 3

1

0

High-throughput

0.426

High

739203

RU1C
U1 small nuclear ribonucleoprotein C

1

0

Small-scale

0.426

High

739223

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

739225

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

1

0

Small-scale

0.426

High

585233

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

5

Small-scale

0.407

High

739141

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.407

High

739217

YP257
Uncharacterized membrane protein YPL257W

1

0

High-throughput

0.265

Low

739228

YO314
Uncharacterized protein YOR314W

1

0

High-throughput

0.238

Low

739199

KFA
Kynurenine formamidase

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025