HitPredict

Interactor 1: SET1 (Q5LJZ2)
Histone-lysine N-methyltransferase SETD1 (EC 2.1.1.354)
Gene: SET1

Interactor 2: WDS (Q9V3J8)
Protein will die slowly
Gene: WDS

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	22048023, 21694722
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0048188 - Set1C/COMPASS complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1641 Dm			1 361
+	Hs
		1155633 EZH2_HUMAN (1099-1624): 5.08e-94: 324: 15.59		FBXW7_HUMAN (4-309): 2.21e-81: 263: 25.16
+	Hs
		1041577 KMT2A_HUMAN (1127-1641): 2.53e-76: 284: 22.03		FBXW7_HUMAN (4-309): 2.21e-81: 263: 25.16
+	Hs
		1387545 SETD2_HUMAN (1097-1640): 3.82e-83: 306: 13.71		SNR40_HUMAN (106-361): 7.15e-71: 226: 24.35
+	Hs
		1041578 KMT2A_HUMAN (1127-1641): 2.53e-76: 284: 22.03		SNR40_HUMAN (106-361): 7.15e-71: 226: 24.35
+	Hs
		161502 KMT2D_HUMAN (1405-1641): 5.97e-61: 234: 37.76		FBXW7_HUMAN (4-309): 2.21e-81: 263: 25.16
+	Hs
		964869 KMT2A_HUMAN (1127-1641): 2.53e-76: 284: 22.03		WDR5_HUMAN (4-225): 2.3e-64: 209: 26.75
+	Hs
		1387641 KMT2B_HUMAN (1275-1641): 3.91e-69: 260: 28.65		SNR40_HUMAN (106-361): 7.15e-71: 226: 24.35
+	Hs
		175868 SET1A_HUMAN (1199-1641): 1.87e-74: 277: 40.22		WDR5_HUMAN (4-225): 2.3e-64: 209: 26.75
+	Hs
		355576 NSD2_HUMAN (1382-1640): 5.17e-67: 252: 22.43		SNR40_HUMAN (106-361): 7.15e-71: 226: 24.35
+	Hs
		1387546 NSD3_HUMAN (1398-1640): 9.06e-65: 245: 22.67		SNR40_HUMAN (106-361): 7.15e-71: 226: 24.35
+	Hs
		965330 KMT2B_HUMAN (1275-1641): 3.91e-69: 260: 28.65		WDR5_HUMAN (4-225): 2.3e-64: 209: 26.75
+	Hs
		965335 SET1B_HUMAN (27-310): 4.57e-62: 237: 25.90		WDR5_HUMAN (4-225): 2.3e-64: 209: 26.75
+	Hs
		161443 KMT2D_HUMAN (1405-1641): 5.97e-61: 234: 37.76		WDR5_HUMAN (4-225): 2.3e-64: 209: 26.75
+	Hs
		161486 KMT2D_HUMAN (1405-1641): 5.97e-61: 234: 37.76		WDR5B_HUMAN (4-225): 1.89e-63: 206: 26.75
+	Hs
		222488 EZH2_HUMAN (1099-1624): 5.08e-94: 324: 15.59		PLRG1_HUMAN (233-361): 1.41e-26: 112: 24.03
+	Hs
		1419379 SETD2_HUMAN (1097-1640): 3.82e-83: 306: 13.71		NLE1_HUMAN (224-359): 5.75e-32: 127: 21.83
+	Sc
		793854 SET1_YEAST (1086-1641): 1.83e-75: 276: 25.80		SWD3_YEAST (76-357): 1.94e-42: 151: 33.44
+	Zm
		35832 A0A1D6M742_MAIZE (1044-1638): 1.41e-88: 306: 12.78		A0A1D6LQJ4_MAIZE (275-361): 8.63e-14: 73.3: 30.34
+	Hs
		216486 SUV91_HUMAN (1288-1640): 8.57e-81: 274: 15.80		DAW1_HUMAN (256-361): 2.87e-13: 72.4: 23.73
+	Hs
		161490 KMT2D_HUMAN (1405-1641): 5.97e-61: 234: 37.76		POC1A_HUMAN (5-102): 5.84e-18: 86.2: 19.39