HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBP46 (P62068)
Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46)
Gene: USP46

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	29576527
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UCH~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 366
+	Hs
		259261 UBC_HUMAN (1-685): 0: 846: 100.00		UBP12_HUMAN (1-366): 6.21e-137: 396: 88.53
+	Hs
		476400 UBC_HUMAN (1-685): 0: 846: 100.00		UBP42_HUMAN (35-364): 3.66e-105: 338: 26.51
+	Hs
		475440 UBC_HUMAN (1-685): 0: 846: 100.00		UBP8_HUMAN (4-363): 5.23e-103: 329: 26.37
+	Hs
		476493 UBC_HUMAN (1-685): 0: 846: 100.00		UBP36_HUMAN (35-364): 2.59e-102: 327: 26.81
+	Hs
		475932 UBC_HUMAN (1-685): 0: 846: 100.00		U17L2_HUMAN (18-365): 1.86e-107: 326: 25.14
+	Hs
		271022 UBC_HUMAN (1-685): 0: 846: 100.00		UBP2_HUMAN (26-363): 2.61e-102: 315: 26.33
+	Hs
		476545 UBC_HUMAN (1-685): 0: 846: 100.00		UBP21_HUMAN (19-366): 6.83e-100: 308: 24.67
+	Hs
		476579 UBC_HUMAN (1-685): 0: 846: 100.00		UBP22_HUMAN (28-365): 9.67e-99: 304: 25.92
+	Hs
		64200 UBC_HUMAN (1-685): 0: 846: 100.00		UBP27_HUMAN (31-365): 5.21e-99: 301: 24.07
+	Hs
		476658 UBC_HUMAN (1-685): 0: 846: 100.00		UBP3_HUMAN (14-366): 3.27e-94: 292: 27.62
+	At
		1210479 UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80		UBP15_ARATH (31-364): 7.35e-99: 314: 26.92
+	At
		1092065 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBP15_ARATH (31-364): 7.35e-99: 314: 26.92
+	Mm
		476741 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP46_MOUSE (1-366): 1.46e-142: 410: 100.00
+	Mm
		477008 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP12_MOUSE (1-366): 6.63e-138: 398: 88.25
+	Sc
		477366 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP8_YEAST (36-366): 1.17e-30: 123: 29.89
+	Hs
		924201 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		UBP36_HUMAN (35-364): 2.59e-102: 327: 26.81
+	Mm
		476865 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP8_MOUSE (1-363): 3.06e-102: 326: 26.17
+	Rn
		1137288 UBC_RAT (1-108): 1.27e-29: 127: 90.74		UBP2_RAT (7-363): 5.66e-103: 317: 25.46
+	Hs
		398134 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		UBP21_HUMAN (19-366): 6.83e-100: 308: 24.67
+	Mm
		476939 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP3_MOUSE (14-366): 2.78e-94: 292: 28.13