HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Property	Details
Experiments	28190767, 27182664, 38803224, 28924046, 32296183, 9575161, 23439649, unassigned1304
Identification Methods	pull down, proximity labelling technology, enzymatic study, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 875
+	Hs
		475470 UBC_HUMAN (1-685): 0: 846: 100.00		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		125113 UBC_HUMAN (1-685): 0: 846: 100.00		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Hs
		475785 UBC_HUMAN (1-685): 0: 846: 100.00		HERC3_HUMAN (139-874): 0: 582: 26.85
+	Hs
		476205 UBC_HUMAN (1-685): 0: 846: 100.00		ITCH_HUMAN (325-873): 0: 579: 24.78
+	Hs
		476229 UBC_HUMAN (1-685): 0: 846: 100.00		NED4L_HUMAN (247-873): 0: 575: 22.52
+	Hs
		476350 UBC_HUMAN (1-685): 0: 846: 100.00		WWP1_HUMAN (185-873): 0: 560: 22.22
+	Hs
		476403 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF2_HUMAN (334-872): 0: 554: 24.79
+	Hs
		475871 UBC_HUMAN (1-685): 0: 846: 100.00		HERC4_HUMAN (157-875): 3.32e-179: 547: 27.46
+	Hs
		476414 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04
+	Hs
		475984 UBC_HUMAN (1-685): 0: 846: 100.00		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97
+	Hs
		475799 UBC_HUMAN (1-685): 0: 846: 100.00		UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27
+	Sc
		477293 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		RSP5_YEAST (310-873): 0: 554: 25.85
+	At
		1091758 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UPL1_ARATH (435-874): 1.26e-154: 504: 32.60
+	At
		1091762 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UPL2_ARATH (336-874): 9.69e-153: 499: 28.09
+	Hs
		125347 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Hs
		924156 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		WWP1_HUMAN (185-873): 0: 560: 22.22
+	Mm
		476846 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		HERC4_MOUSE (157-875): 0: 568: 27.46
+	Mm
		924239 RS27A_MOUSE (609-684): 9.1e-41: 147: 100.00		HUWE1_MOUSE (523-874): 7.59e-53: 203: 33.97
+	Mm
		476858 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		HUWE1_MOUSE (523-874): 7.59e-53: 203: 33.97
+	Mm
		476866 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBE3C_MOUSE (453-872): 3.25e-52: 200: 32.73