HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: TRIPC (Q14669)
E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)
Gene: TRIP12

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	27182664, 29499138, 19028681
Identification Methods	proximity labelling technology, enzymatic study, affinity chromatography technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 1992
+	Hs
		125113 UBC_HUMAN (1-685): 0: 846: 100.00		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		476205 UBC_HUMAN (1-685): 0: 846: 100.00		ITCH_HUMAN (1018-1990): 0: 591: 17.29
+	Hs
		476229 UBC_HUMAN (1-685): 0: 846: 100.00		NED4L_HUMAN (989-1990): 0: 588: 16.37
+	Hs
		476350 UBC_HUMAN (1-685): 0: 846: 100.00		WWP1_HUMAN (1038-1990): 0: 580: 16.88
+	Hs
		476403 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF2_HUMAN (1373-1989): 2.4e-168: 535: 19.18
+	Hs
		475470 UBC_HUMAN (1-685): 0: 846: 100.00		NEDD4_HUMAN (814-1990): 2.08e-159: 528: 13.49
+	Hs
		475871 UBC_HUMAN (1-685): 0: 846: 100.00		HERC4_HUMAN (1290-1991): 1.24e-156: 513: 18.47
+	Hs
		476414 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF1_HUMAN (1455-1989): 1.22e-158: 508: 18.46
+	Hs
		475652 UBC_HUMAN (1-685): 0: 846: 100.00		UBE3A_HUMAN (1492-1991): 2.41e-140: 462: 27.02
+	Sp
		143368 UBI4P_SCHPO (305-685): 1.76e-151: 445: 95.80		PTR1_SCHPO (753-1992): 0: 755: 15.46
+	Dm
		89879 UBIQP_DROME (1-610): 0: 752: 99.84		D5SHR3_DROME (1574-1986): 1.16e-124: 401: 25.90
+	Hs
		476559 UBC_HUMAN (1-685): 0: 846: 100.00		HECD1_HUMAN (437-1230): 6.18e-77: 287: 15.52
+	Sc
		477424 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		TOM1_YEAST (922-1992): 0: 644: 15.37
+	Hs
		475799 UBC_HUMAN (1-685): 0: 846: 100.00		UBE3C_HUMAN (1697-1992): 3.54e-26: 119: 30.57
+	Hs
		475984 UBC_HUMAN (1-685): 0: 846: 100.00		HUWE1_HUMAN (1616-1992): 2.18e-25: 118: 28.72
+	Dm
		1376481 Q9W418_DROME (229-685): 0: 557: 99.78		Q9W325_DROME (1574-1986): 1.24e-124: 401: 25.90
+	Sc
		477293 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		RSP5_YEAST (1422-1990): 3.6e-164: 525: 19.59
+	Sc
		477380 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		HUL5_YEAST (1321-1992): 1.29e-147: 483: 20.12
+	At
		97780 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		IMPA2_ARATH (347-905): 3.96e-160: 504: 15.32
+	Sc
		477197 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UFD4_YEAST (351-962): 4.64e-35: 149: 17.31