HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: GOLI (Q86XS8)
E3 ubiquitin-protein ligase RNF130 (EC 2.3.2.27) (Goliath homolog) (H-Goliath) (RING finger protein 130) (RING-type E3 ubiquitin transferase RNF130)
Gene: RNF130

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	36610398, 16549277
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_2
Common GO terms	GO:0016567 - protein ubiquitination
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 419
+	Hs
		476551 UBC_HUMAN (1-685): 0: 846: 100.00		AMFR_HUMAN (2-346): 7.99e-45: 166: 13.50
+	Hs
		476458 UBC_HUMAN (1-685): 0: 846: 100.00		RNF12_HUMAN (210-311): 1.31e-10: 65.1: 33.33
+	Hs
		476628 UBC_HUMAN (1-685): 0: 846: 100.00		RN115_HUMAN (237-305): 5.8e-11: 65.1: 44.93
+	At
		1210477 UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80		Q9FM98_ARATH (221-356): 5.63e-30: 121: 19.85
+	Hs
		924057 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		GOLI_HUMAN (1-419): 4.48e-123: 365: 100.00
+	Hs
		475090 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		GOLI_HUMAN (1-419): 4.48e-123: 365: 100.00
+	At
		1091813 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		RNG1L_ARATH (131-345): 3.54e-31: 123: 21.01
+	At
		1092053 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		Q9FM98_ARATH (221-356): 5.63e-30: 121: 19.85
+	At
		955780 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		ATL1_ARATH (196-385): 6.79e-30: 121: 15.84
+	At
		477669 UBQ11_ARATH (533-685): 2.54e-59: 201: 95.43		Q9FM98_ARATH (221-356): 5.63e-30: 121: 19.85
+	Hs
		924212 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		AMFR_HUMAN (2-346): 7.99e-45: 166: 13.50
+	Hs
		475059 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RNF43_HUMAN (19-378): 1.06e-57: 203: 17.87
+	Mm
		477046 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		AMFR_MOUSE (2-346): 3.44e-43: 162: 13.50
+	Mm
		477051 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RNF12_MOUSE (210-311): 9.74e-11: 65.5: 33.33
+	Mm
		476994 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN115_MOUSE (237-305): 5.85e-11: 65.1: 44.93
+	Hs
		398150 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		RN115_HUMAN (237-305): 5.8e-11: 65.1: 44.93