Protein: GNAO
Guanine nucleotide-binding protein G(o) subunit alpha (EC 3.6.5.-)

Gene: GNAO, GNAO1
Organism: Homo sapiens
Interactions: 99
UniProt ID: P09471

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0003925 - G protein activity
GO:0005525 - GTP binding
GO:0005737 - cytoplasm
GO:0005834 - heterotrimeric G-protein complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

418573

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

3

12

High-throughput

0.861

High

475876

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

3

12

High-throughput

0.861

High

482601

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

3

14

High-throughput

0.861

High

482641

RIC8A
Chaperone Ric-8A

2

13

Small-scale

0.808

High

482589

RGS4
Regulator of G-protein signaling 4

2

20

Small-scale

0.778

High

193880

RGS5
Regulator of G-protein signaling 5

2

20

Small-scale

0.768

High

482588

RGS19
Regulator of G-protein signaling 19

2

20

Small-scale

0.754

High

482574

GNAT2
Guanine nucleotide-binding protein G(t) subunit alpha-2

1

13

High-throughput

0.691

High

482604

ANK2
Ankyrin-2

1

2

High-throughput

0.691

High

482609

DMWD
Dystrophia myotonica WD repeat-containing protein

1

3

High-throughput

0.691

High

482644

KTU
Protein kintoun

3

1

High-throughput

0.667

High

192032

RGS16
Regulator of G-protein signaling 16

1

20

Small-scale

0.647

High

303102

RGS20
Regulator of G-protein signaling 20

1

20

Small-scale

0.647

High

477185

ADA2A
Alpha-2A adrenergic receptor

1

10

Small-scale

0.647

High

482648

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

1

Small-scale

0.647

High

482600

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

3

20

Small-scale

0.633

High

482602

GBG3

2

20

High-throughput

0.628

High

297293

RGS9
Regulator of G-protein signaling 9

1

20

Small-scale

0.618

High

482577

CXCR5
C-X-C chemokine receptor type 5

1

14

Small-scale

0.618

High

482578

CRFR1
Corticotropin-releasing factor receptor 1

1

5

Small-scale

0.618

High

482579

OPRM
Mu-type opioid receptor

1

17

Small-scale

0.618

High

482580

DRD3
D(3) dopamine receptor

1

6

Small-scale

0.618

High

482584

OPRD
Delta-type opioid receptor

1

17

Small-scale

0.618

High

482636

ECT2
Protein ECT2

1

12

High-throughput

0.618

High

482637

GPR35
G-protein coupled receptor 35

1

20

High-throughput

0.618

High

482619

DGUOK
Deoxyguanosine kinase, mitochondrial

2

1

High-throughput

0.611

High

482649

NUFP1
FMR1-interacting protein NUFIP1

3

3

High-throughput

0.609

High

482650

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

2

20

High-throughput

0.601

High

482585

HD
Huntingtin

2

10

High-throughput

0.588

High

482594

TERA
Transitional endoplasmic reticulum ATPase

2

6

High-throughput

0.588

High

482645

ARMC1
Armadillo repeat-containing protein 1

2

0

High-throughput

0.585

High

482622

CXB7
Gap junction beta-7 protein

2

3

High-throughput

0.574

High

124206

HAX1
HCLS1-associated protein X-1

2

1

High-throughput

0.558

High

478652

HXB5
Homeobox protein Hox-B5

2

4

High-throughput

0.558

High

255367

SNX2
Sorting nexin-2

1

5

High-throughput

0.536

High

482573

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.536

High

482590

GBG10

1

20

High-throughput

0.536

High

482591

GPM6A
Neuronal membrane glycoprotein M6-a

1

2

High-throughput

0.536

High

482595

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

20

High-throughput

0.536

High

482596

ACTB
Actin, cytoplasmic 1

1

2

High-throughput

0.536

High

482599

ACTA
Actin, aortic smooth muscle

1

2

High-throughput

0.536

High

482608

CD69
Early activation antigen CD69

1

3

High-throughput

0.536

High

482613

SNX1
Sorting nexin-1

1

5

High-throughput

0.536

High

482615

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.536

High

482625

MICA1
[F-actin]-monooxygenase MICAL1

1

2

High-throughput

0.536

High

482626

KIFA3
Kinesin-associated protein 3

1

1

High-throughput

0.536

High

482632

SCN2A
Sodium channel protein type 2 subunit alpha

1

11

High-throughput

0.536

High

482643

DUS22
Dual specificity protein phosphatase 22

1

14

High-throughput

0.536

High

482652

MYH4
Myosin-4

1

2

High-throughput

0.536

High

482612

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.518

High

482575

CALR
Calreticulin

1

1

High-throughput

0.515

High

482582

TGFR2
TGF-beta receptor type-2

1

2

High-throughput

0.515

High

482592

KS6A3
Ribosomal protein S6 kinase alpha-3

1

4

High-throughput

0.515

High

482624

NEK7
Serine/threonine-protein kinase Nek7

1

5

High-throughput

0.515

High

482634

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

1

0

High-throughput

0.513

High

482603

CAC1B
Voltage-dependent N-type calcium channel subunit alpha-1B

1

11

Small-scale

0.501

High

482607

APLP2
Amyloid beta precursor like protein 2

1

6

Small-scale

0.501

High

482639

NGB
Neuroglobin

1

1

Small-scale

0.501

High

482631

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

12

High-throughput

0.500

High

482627

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

4

High-throughput

0.489

High

482628

CERS2
Ceramide synthase 2

1

2

High-throughput

0.489

High

482651

SNX5
Sorting nexin-5

1

5

High-throughput

0.489

High

330597

KI20A
Kinesin-like protein KIF20A

1

19

High-throughput

0.479

High

347484

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

411229

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

421359

A4
Amyloid-beta precursor protein

1

6

Small-scale

0.479

High

482583

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

482587

YAP1
Transcriptional coactivator YAP1

1

9

High-throughput

0.479

High

482593

MOT1
Monocarboxylate transporter 1

1

6

High-throughput

0.479

High

482598

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.479

High

482610

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.479

High

482617

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

482623

EMC5
ER membrane protein complex subunit 5

1

3

High-throughput

0.479

High

482635

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.479

High

482646

GBG12

1

20

High-throughput

0.479

High

482647

HDAC6
Protein deacetylase HDAC6

1

6

High-throughput

0.479

High

482576

ABCD3
ATP-binding cassette sub-family D member 3

1

1

High-throughput

0.470

High

166246

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.458

High

482618

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.458

High

482606

ZBT16
Zinc finger and BTB domain-containing protein 16

1

1

Small-scale

0.457

High

254753

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

7

High-throughput

0.445

High

482605

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.445

High

482616

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

11

High-throughput

0.445

High

105172

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

482611

TFCP2
Alpha-globin transcription factor CP2

1

8

High-throughput

0.437

High

482638

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

8

High-throughput

0.437

High

482642

ANLN
Anillin

1

8

High-throughput

0.437

High

482597

SMS
Somatostatin

1

0

Small-scale

0.426

High

482614

CUL3
Cullin-3

1

0

High-throughput

0.426

High

482630

CEP63
Centrosomal protein of 63 kDa

1

5

High-throughput

0.407

High

482633

ZBT18
Zinc finger and BTB domain-containing protein 18

1

4

High-throughput

0.407

High

482629

JSPR1
Junctional sarcoplasmic reticulum protein 1

3

0

High-throughput

0.347

High

288273

SPAG6
Sperm-associated antigen 6

1

0

High-throughput

0.279

Low

482620

GRAM4
GRAM domain-containing protein 4

1

0

High-throughput

0.279

Low

482621

FXL22
F-box and leucine-rich protein 22

1

0

High-throughput

0.279

Low

482640

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.279

Low

482581

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.268

Low

482586

CBX5
Chromobox protein homolog 5

1

0

High-throughput

0.268

Low

231790

MFS11
UNC93-like protein MFSD11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025