HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: HOIL1 (Q9BYM8)
RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3)
Gene: RBCK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.983

Property	Details
Experiments	20005846, 28190767, 34755089, 35170849, 35274759, 38803224, 17006537, 19796170, 22139374, 23986494, 29694895, 18303026, 36631489
Identification Methods	pull down, affinity chromatography technology, enzymatic study, x-ray crystallography
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_UBOX
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 510
+	Hs
		476348 UBC_HUMAN (1-685): 0: 846: 100.00		SHRPN_HUMAN (7-232): 2.94e-75: 244: 39.66
+	Hs
		476630 UBC_HUMAN (1-685): 0: 846: 100.00		ARI1_HUMAN (216-496): 1.87e-68: 231: 18.09
+	Hs
		476496 UBC_HUMAN (1-685): 0: 846: 100.00		AKIB1_HUMAN (233-503): 2.64e-65: 230: 15.92
+	Hs
		312458 UBC_HUMAN (1-685): 0: 846: 100.00		ARI2_HUMAN (243-496): 7.23e-65: 220: 19.85
+	Hs
		475939 UBC_HUMAN (1-685): 0: 846: 100.00		RN19B_HUMAN (277-477): 1.57e-57: 205: 22.97
+	Hs
		476460 UBC_HUMAN (1-685): 0: 846: 100.00		RN216_HUMAN (235-497): 5.21e-52: 191: 19.13
+	Hs
		226335 UBC_HUMAN (1-685): 0: 846: 100.00		PRKN_HUMAN (210-489): 2.2e-53: 188: 19.80
+	Hs
		475976 UBC_HUMAN (1-685): 0: 846: 100.00		R144B_HUMAN (276-477): 1.67e-54: 187: 20.57
+	Hs
		475494 UBC_HUMAN (1-685): 0: 846: 100.00		R144A_HUMAN (279-476): 3.85e-28: 115: 20.98
+	Mm
		477054 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		HOIL1_MOUSE (1-510): 0: 562: 91.18
+	Sc
		477225 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		HEL1_YEAST (233-498): 4.49e-62: 214: 17.86
+	At
		1092233 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		Q9M1E9_ARATH (282-484): 4.19e-29: 120: 23.11
+	Mm
		476941 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		SHRPN_MOUSE (7-232): 1.12e-74: 242: 38.53
+	Hs
		227107 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		PRKN_HUMAN (210-489): 2.2e-53: 188: 19.80
+	Hs
		312457 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		ARI2_HUMAN (243-496): 7.23e-65: 220: 19.85
+	Mm
		476729 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN216_MOUSE (235-497): 1.11e-50: 187: 18.77
+	Hs
		475069 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RN19B_HUMAN (277-477): 1.57e-57: 205: 22.97
+	Hs
		226251 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		PRKN_HUMAN (210-489): 2.2e-53: 188: 19.80
+	Hs
		171468 UBD_HUMAN (155-304): 5.41e-28: 112: 32.05		PRKN_HUMAN (210-489): 2.2e-53: 188: 19.80
+	Hs
		226334 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		PRKN_HUMAN (210-489): 2.2e-53: 188: 19.80