HitPredict

Interactor 1: TPM1 (P09493)
Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)
Gene: TPM1

Interactor 2: CNN1 (P51911)
Calponin-1 (Basic calponin) (Calponin H1, smooth muscle)
Gene: CNN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.585

Property	Details
Experiments	2161834, 2455687
Identification Methods	pull down, biochemical
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005856 - cytoskeleton GO:0007015 - actin filament organization GO:0015629 - actin cytoskeleton GO:0051015 - actin filament binding GO:1904706 - negative regulation of vascular associated smooth muscle cell proliferation
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 284 Hs			1 297
+	Hs
		117300 K7ENT6_HUMAN (72-284): 1.3e-55: 181: 77.00		TAGL_HUMAN (6-188): 2.71e-67: 210: 39.39
+	Dm
		482723 TPM2_DROME (1-282): 7.78e-35: 128: 49.29		MP20_DROME (13-188): 3.45e-60: 191: 35.00
+	Dm
		482768 TPM2_DROME (1-282): 7.78e-35: 128: 49.29		Q9I7J0_DROME (26-188): 1.43e-56: 181: 41.57
+	Hs
		482855 TPM1_HUMAN (1-284): 2.36e-44: 153: 100.00		IQGA1_HUMAN (7-172): 2.17e-41: 154: 16.85
+	Hs
		447706 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		IQGA1_HUMAN (7-172): 2.17e-41: 154: 16.85
+	Hs
		464130 TPM2_HUMAN (1-284): 1.4e-38: 138: 85.56		IQGA1_HUMAN (7-172): 2.17e-41: 154: 16.85
+	Hs
		116463 H7BYY1_HUMAN (41-284): 8.18e-35: 127: 70.49		IQGA1_HUMAN (7-172): 2.17e-41: 154: 16.85
+	Hs
		862798 TPM4_HUMAN (42-284): 3.78e-33: 123: 68.72		IQGA1_HUMAN (7-172): 2.17e-41: 154: 16.85