HitPredict

Interactor 1: CCL3 (P10147)
C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))]
Gene: CCL3

Interactor 2: CCR4 (P51679)
C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194)
Gene: CCR4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	8573157
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0019722 - calcium-mediated signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 92 Hs			1 360
+	Hs
		134354 CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00		ACKR2_HUMAN (4-324): 1.53e-88: 273: 41.30
+	Hs
		134356 CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61		ACKR2_HUMAN (4-324): 1.53e-88: 273: 41.30
+	Hs
		134400 CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71		ACKR2_HUMAN (4-324): 1.53e-88: 273: 41.30
+	Hs
		486230 CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00		CCR1_HUMAN (27-360): 1.43e-79: 249: 49.11
+	Hs
		561728 CL3L1_HUMAN (1-92): 2.12e-35: 117: 94.62		CCR1_HUMAN (27-360): 1.43e-79: 249: 49.11
+	Hs
		526560 CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61		CCR1_HUMAN (27-360): 1.43e-79: 249: 49.11
+	Mm
		500591 CCL3_MOUSE (1-92): 6.45e-34: 113: 74.19		CCR3_MOUSE (1-357): 6.16e-79: 247: 45.40
+	Hs
		783833 CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71		CCR2_HUMAN (10-334): 7.48e-77: 242: 47.24
+	Hs
		486239 CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00		CCR5_HUMAN (25-360): 1.7e-71: 228: 49.70
+	Hs
		486237 CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00		CCR3_HUMAN (14-357): 1.14e-70: 226: 45.38
+	Hs
		561733 CL3L1_HUMAN (1-92): 2.12e-35: 117: 94.62		CCR5_HUMAN (25-360): 1.7e-71: 228: 49.70
+	Mm
		500590 CCL3_MOUSE (1-92): 6.45e-34: 113: 74.19		CCR1_MOUSE (5-360): 1.83e-72: 230: 44.69
+	Hs
		561732 CL3L1_HUMAN (1-92): 2.12e-35: 117: 94.62		CCR3_HUMAN (14-357): 1.14e-70: 226: 45.38
+	Hs
		526565 CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61		CCR5_HUMAN (25-360): 1.7e-71: 228: 49.70
+	Hs
		849654 CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71		CCR5_HUMAN (25-360): 1.7e-71: 228: 49.70
+	Hs
		526564 CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61		CCR3_HUMAN (14-357): 1.14e-70: 226: 45.38
+	Hs
		849619 CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71		CCR3_HUMAN (14-357): 1.14e-70: 226: 45.38
+	Hs
		486231 CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00		CXCR5_HUMAN (16-330): 6e-47: 165: 34.26
+	Hs
		830629 CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71		CXCR3_HUMAN (28-319): 1.12e-49: 172: 38.31
+	Hs
		526561 CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61		CXCR5_HUMAN (16-330): 6e-47: 165: 34.26