HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: DYN3 (Q9UQ16)
Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin)
Gene: DNM3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005874 - microtubule GO:0005886 - plasma membrane GO:0007416 - synapse assembly GO:0008017 - microtubule binding and 2 others more... GO:0030424 - axon GO:0043197 - dendritic spine
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 869
+	Hs
		496584 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Rn
		581993 TAU_RAT (1-758): 4.86e-75: 260: 71.47		DYN3_RAT (1-869): 0: 1079: 97.12
+	Rn
		94215 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		DYN3_RAT (1-869): 0: 1079: 97.12
+	Hs
		496899 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DYN1_HUMAN (1-852): 0: 1035: 78.56
+	Rn
		581924 TAU_RAT (1-758): 4.86e-75: 260: 71.47		DYN1_RAT (1-852): 0: 1028: 78.22
+	Rn
		94147 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		DYN1_RAT (1-852): 0: 1028: 78.22
+	Hs
		128409 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DNM1L_HUMAN (6-750): 0: 788: 38.25
+	Rn
		192574 TAU_RAT (1-758): 4.86e-75: 260: 71.47		DNM1L_RAT (6-750): 0: 783: 37.48
+	Rn
		94103 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		DNM1L_RAT (6-750): 0: 783: 37.48
+	Mm
		498094 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		DNM1L_MOUSE (6-750): 0: 779: 37.99
+	Hs
		92113 NACAM_HUMAN (203-750): 1.03e-12: 74.3: 9.75		DNM1L_HUMAN (6-750): 0: 788: 38.25
+	Hs
		231048 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		OPA1_HUMAN (7-660): 1.13e-158: 490: 19.02