HitPredict

Interactor 1: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Interactor 2: PRKX (P51817)
cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1)
Gene: PRKX

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	10026146, 16491121
Identification Methods	pull down, two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Pkinase~cNMP_binding, Pkinase~RIIa
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005952 - cAMP-dependent protein kinase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 381 Hs			1 358
+	Hs
		498221 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		AKT1_HUMAN (11-351): 1.63e-150: 434: 37.68
+	Mm
		397222 KAP0_MOUSE (1-381): 2.58e-141: 408: 96.85		KAPCA_MOUSE (5-358): 1.69e-150: 429: 49.44
+	Hs
		498202 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		KAPCA_HUMAN (5-358): 8.26e-152: 432: 49.72
+	Hs
		498210 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		KAPCB_HUMAN (5-358): 2.49e-151: 431: 49.72
+	Hs
		568558 KAP1_HUMAN (1-381): 1.35e-138: 401: 81.37		KAPCA_HUMAN (5-358): 8.26e-152: 432: 49.72
+	Hs
		610685 KAP1_HUMAN (1-381): 1.35e-138: 401: 81.37		KAPCB_HUMAN (5-358): 2.49e-151: 431: 49.72
+	Hs
		498208 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		KAPCG_HUMAN (38-358): 1.21e-149: 427: 46.73
+	Hs
		609646 KAP1_HUMAN (1-381): 1.35e-138: 401: 81.37		KAPCG_HUMAN (38-358): 1.21e-149: 427: 46.73
+	Dm
		519451 KAPR1_DROME (6-381): 8.96e-131: 381: 71.54		KAPC1_DROME (38-358): 7.5e-146: 417: 49.84
+	Dm
		519457 KAPR2_DROME (27-377): 8.76e-104: 312: 37.85		KAPC1_DROME (38-358): 7.5e-146: 417: 49.84
+	Hs
		498233 KAP0_HUMAN (1-381): 1.4e-139: 404: 100.00		KS6A3_HUMAN (2-316): 9.2e-102: 317: 28.19
+	Sc
		412929 KAPR_YEAST (81-369): 6.42e-86: 268: 37.24		KAPB_YEAST (30-358): 5.92e-147: 421: 47.58
+	Sc
		412617 KAPR_YEAST (81-369): 6.42e-86: 268: 37.24		KAPA_YEAST (35-358): 4.74e-146: 420: 48.00
+	Sc
		409586 KAPR_YEAST (81-369): 6.42e-86: 268: 37.24		KAPC_YEAST (2-358): 2.29e-145: 418: 44.13
+	Sp
		736930 KAPR_SCHPO (28-369): 1.79e-75: 241: 28.79		KAPB_SCHPO (35-358): 1e-144: 421: 46.01
+	Ca
		1124295 KAPR_CANAL (43-369): 5.79e-68: 223: 34.65		Q5AP71_CANAL (38-358): 2.09e-142: 410: 48.46
+	Hs
		217858 KAP3_HUMAN (10-253): 4.9e-21: 95.9: 18.21		PRKY_HUMAN (1-272): 0: 506: 92.28
+	Mm
		397199 KAP3_MOUSE (10-253): 2.54e-21: 96.6: 18.57		KAPCA_MOUSE (5-358): 1.69e-150: 429: 49.44
+	Hs
		1047564 KGP1_HUMAN (118-320): 1.3e-22: 101: 21.53		KGP1_HUMAN (46-351): 4.85e-96: 301: 45.34
+	Bt
		337287 KGP1_BOVIN (118-320): 1.23e-22: 101: 21.53		KGP1_BOVIN (46-351): 4.79e-96: 301: 45.34