HitPredict

Interactor 1: VATB2 (P21281)
V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2)
Gene: ATP6V1B2

Interactor 2: VATA (P38606)
V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha)
Gene: ATP6V1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.967

The method score is based on:

Property Details
Experiments 33961781, 35271311, 37071682, 38334954, 37831778, 35235311, 31839598, 40437099, 21674799, unassigned3799
Identification Methods affinity chromatography technology, cross-linking study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains ATP-synt_ab~ATP-synt_ab, ATP-synt_ab~ATP-synt_ab_N, ATP-synt_ab~ATP-synt_ab_Xtn, ATP-synt_VA_C~ATP-synt_ab, ATP-synt_ab_N~ATP-synt_ab_N, ATP-synt_ab_N~ATP-synt_ab_Xtn, ATP-synt_VA_C~ATP-synt_ab_N, ATP-synt_VA_C~ATP-synt_ab_Xtn, ATP-synt_VA_C~ATP-synt_VA_C
Common GO terms GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain
GO:0005524 - ATP binding
GO:0005765 - lysosomal membrane
GO:0005829 - cytosol
GO:0005886 - plasma membrane
and 12 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 511
Hs

1 617
+ Mm
+ Hs
+ Mm
+ Dm
+ Dm
+ Tt
+ Hs
+ Mm
+ Sc
+ Mm
+ Nv
+ Ec
+ Hp
+ Ec
+ So
+ At
+ Se
+ Cp

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Last updated: 11Aug2025