HitPredict

Interactor 1: THA (P10827)
Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha)
Gene: THRA

Interactor 2: MED21 (Q13503)
Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNA polymerase II holoenzyme component SRB7) (RNAPII complex component SRB7) (hSrb7)
Gene: MED21

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	10198638, 15249124
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 144
+	Hs
		500481 THB_HUMAN (40-404): 8.75e-113: 342: 74.66		MED21_HUMAN (1-144): 1.5e-69: 207: 100.00
+	Hs
		369547 ESR1_HUMAN (1-442): 2.2e-108: 336: 19.04		MED21_HUMAN (1-144): 1.5e-69: 207: 100.00
+	Hs
		782539 HNF4A_HUMAN (8-451): 1.23e-104: 322: 21.87		MED21_HUMAN (1-144): 1.5e-69: 207: 100.00