Protein: GYRA
DNA gyrase subunit A (EC 5.6.2.2)

Gene: GYRA
Organism: Escherichia coli K-12
Interactions: 60
UniProt ID: P0AES4

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003918 - DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 - ATP binding
GO:0005694 - chromosome
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

500416

GYRA
DNA gyrase subunit A

4

6

Small-scale

0.894

High

500417

GYRB
DNA gyrase subunit B

2

12

Small-scale

0.759

High

500440

CCDB
Toxin CcdB

1

0

Small-scale

0.687

High

500419

PARC
DNA topoisomerase 4 subunit A

1

6

High-throughput

0.625

High

493746

RS2
Small ribosomal subunit protein uS2

2

1

High-throughput

0.612

High

494791

SSRP
SsrA-binding protein

2

1

High-throughput

0.601

High

473279

DNAJ
Chaperone protein DnaJ

2

1

High-throughput

0.588

High

497328

MREB
Cell shape-determining protein MreB

2

6

High-throughput

0.588

High

498370

CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

2

2

High-throughput

0.588

High

500424

EFTU1
Elongation factor Tu 1

2

1

High-throughput

0.588

High

500423

SSB
Single-stranded DNA-binding protein

2

1

High-throughput

0.571

High

491544

KDSA
2-dehydro-3-deoxyphosphooctonate aldolase

2

0

High-throughput

0.563

High

492291

RECA
Protein RecA

2

0

High-throughput

0.563

High

494736

METK
S-adenosylmethionine synthase

2

0

High-throughput

0.563

High

500418

MOG
Molybdopterin adenylyltransferase

2

0

High-throughput

0.563

High

500421

RHO
Transcription termination factor Rho

2

0

High-throughput

0.563

High

500429

ADD
Adenosine deaminase

2

0

High-throughput

0.563

High

500445

HSCC
Chaperone protein HscC

1

3

High-throughput

0.536

High

495416

YACG
DNA gyrase inhibitor YacG

1

0

High-throughput

0.523

High

362090

AAT
Aspartate aminotransferase

1

0

High-throughput

0.513

High

500426

SYR
Arginine--tRNA ligase

1

0

High-throughput

0.513

High

500427

FDHE
Protein FdhE

1

0

High-throughput

0.513

High

500430

ACRD
Probable aminoglycoside efflux pump

1

0

High-throughput

0.513

High

500431

LPXM
Lipid A biosynthesis myristoyltransferase

1

0

High-throughput

0.513

High

500435

CAS3
CRISPR-associated endonuclease/helicase Cas3

1

0

High-throughput

0.513

High

500446

LSRK
Autoinducer-2 kinase

1

0

High-throughput

0.513

High

449845

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

1

3

High-throughput

0.484

High

491090

DNAK
Chaperone protein DnaK

1

3

High-throughput

0.484

High

494277

RS5
Small ribosomal subunit protein uS5

1

1

High-throughput

0.484

High

497007

DLDH
Dihydrolipoyl dehydrogenase

1

1

High-throughput

0.484

High

497785

PSTB
Phosphate import ATP-binding protein PstB

1

1

High-throughput

0.484

High

500422

SRP54
Signal recognition particle protein

1

1

High-throughput

0.484

High

500441

MALK
Maltose/maltodextrin import ATP-binding protein MalK

1

1

High-throughput

0.484

High

491495

IF3
Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S]

1

1

High-throughput

0.479

High

368978

SYGB
Glycine--tRNA ligase beta subunit

1

0

High-throughput

0.464

High

490254

CLPP
ATP-dependent Clp protease proteolytic subunit

1

0

High-throughput

0.464

High

496425

FTSZ
Cell division protein FtsZ

1

0

High-throughput

0.464

High

500428

ZRAS
Sensor histidine kinase ZraS

1

0

High-throughput

0.464

High

500437

YJFZ
Uncharacterized protein YjfZ

1

0

High-throughput

0.464

High

500420

GCH1L
GTP cyclohydrolase 1 type 2 homolog

1

0

High-throughput

0.458

High

500433

SBMC
DNA gyrase inhibitor

1

0

Small-scale

0.458

High

500439

CCDA
Antitoxin CcdA

1

0

Small-scale

0.458

High

500442

YNCE
Uncharacterized protein YncE

1

0

High-throughput

0.458

High

500444

YFFS
Uncharacterized protein YffS

1

0

High-throughput

0.458

High

492867

RL27
Large ribosomal subunit protein bL27

1

1

High-throughput

0.457

High

500425

EFTU2
Elongation factor Tu 2

1

1

High-throughput

0.445

High

490775

RSMG
Ribosomal RNA small subunit methyltransferase G

1

0

High-throughput

0.438

High

493124

RL36
Large ribosomal subunit protein bL36A

1

0

High-throughput

0.438

High

493573

RS19
Small ribosomal subunit protein uS19

1

0

High-throughput

0.438

High

500065

CHEY
Chemotaxis protein CheY

1

0

High-throughput

0.438

High

500432

FLIS
Flagellar secretion chaperone FliS

1

0

High-throughput

0.438

High

500434

DHAM
PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM

1

0

High-throughput

0.426

High

491895

NRDI
Protein NrdI

1

0

High-throughput

0.279

Low

497130

IDNO
5-keto-D-gluconate 5-reductase

1

0

High-throughput

0.279

Low

500436

YJEJ
Uncharacterized protein YjeJ

1

0

High-throughput

0.279

Low

500438

RTCB
RNA-splicing ligase RtcB

1

0

High-throughput

0.279

Low

498723

FLIG
Flagellar motor switch protein FliG

1

0

High-throughput

0.238

Low

500345

FLGM
Negative regulator of flagellin synthesis

1

0

High-throughput

0.238

Low

500443

A2MGH
Putative alpha-2-macroglobulin homolog

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025