HitPredict

Interactor 1: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Interactor 2: AAK1 (Q2M2I8)
AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)
Gene: AAK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26496610, 36736316
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 961
+	Hs
		502597 BIP_HUMAN (19-654): 0: 914: 100.00		BMP2K_HUMAN (37-767): 7.31e-125: 409: 47.28
+	Hs
		503528 HSP7C_HUMAN (26-637): 0: 916: 66.02		AKT1_HUMAN (7-386): 1.25e-118: 373: 16.50
+	Hs
		564016 HSP76_HUMAN (25-635): 0: 915: 62.54		AKT1_HUMAN (7-386): 1.25e-118: 373: 16.50
+	Hs
		501740 BIP_HUMAN (19-654): 0: 914: 100.00		AKT1_HUMAN (7-386): 1.25e-118: 373: 16.50
+	Hs
		229919 HSP7C_HUMAN (26-637): 0: 916: 66.02		NUAK1_HUMAN (43-478): 6.05e-102: 334: 23.21
+	Hs
		229918 BIP_HUMAN (19-654): 0: 914: 100.00		NUAK1_HUMAN (43-478): 6.05e-102: 334: 23.21
+	Hs
		161616 HSP7C_HUMAN (26-637): 0: 916: 66.02		GAK_HUMAN (18-309): 7.18e-44: 175: 38.33
+	Hs
		713928 HS71L_HUMAN (24-647): 0: 922: 63.16		NEK2_HUMAN (81-307): 4.75e-15: 80.9: 29.41
+	Hs
		503722 HSP7C_HUMAN (26-637): 0: 916: 66.02		NEK2_HUMAN (81-307): 4.75e-15: 80.9: 29.41
+	Hs
		501855 BIP_HUMAN (19-654): 0: 914: 100.00		NEK2_HUMAN (81-307): 4.75e-15: 80.9: 29.41