HitPredict

Interactor 1: HSP7C (P11142)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Gene: HSPA8

Interactor 2: KCND2 (Q9NZV8)
Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2)
Gene: KCND2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0043197 - dendritic spine GO:0043204 - perikaryon GO:0098978 - glutamatergic synapse GO:0099634 - postsynaptic specialization membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 630
+	Hs
		504926 HSP7C_HUMAN (1-646): 0: 967: 100.00		KCND3_HUMAN (1-626): 0: 572: 73.99
+	Mm
		571856 HS71B_MOUSE (1-646): 0: 957: 83.90		KCNB1_MOUSE (19-620): 1.76e-147: 450: 27.71
+	Mm
		926132 HSP7C_MOUSE (1-646): 0: 967: 99.85		KCNA5_MOUSE (6-492): 4.1e-125: 384: 30.17
+	Hs
		503936 HSP7C_HUMAN (1-646): 0: 967: 100.00		KCNC4_HUMAN (32-555): 3.79e-124: 382: 27.14
+	Hs
		503437 HSP7C_HUMAN (1-646): 0: 967: 100.00		KCNA5_HUMAN (33-492): 2.06e-123: 380: 30.56
+	Hs
		871534 HSP72_HUMAN (2-646): 0: 940: 85.47		KCNC4_HUMAN (32-555): 3.79e-124: 382: 27.14