HitPredict

Interactor 1: BCR (P11274)
Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)
Gene: BCR

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C2~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1271 Hs			1 583
+	Hs
		442768 BCR_HUMAN (1-1271): 0: 1005: 100.00		HCK_HUMAN (348-575): 2.72e-43: 164: 17.16
+	Hs
		506520 BCR_HUMAN (1-1271): 0: 1005: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		426941 BCR_HUMAN (1-1271): 0: 1005: 100.00		FES_HUMAN (326-581): 1.46e-37: 150: 21.79
+	Hs
		129182 BCR_HUMAN (1-1271): 0: 1005: 100.00		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Mm
		1160687 BCR_MOUSE (1-1271): 0: 941: 93.79		SH2D5_MOUSE (191-575): 2.18e-43: 162: 14.47
+	Mm
		57448 BCR_MOUSE (1-1271): 0: 941: 93.79		A2AM67_MOUSE (191-575): 2.18e-43: 162: 14.47
+	Hs
		506565 BCR_HUMAN (1-1271): 0: 1005: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		506586 BCR_HUMAN (1-1271): 0: 1005: 100.00		GRAP_HUMAN (482-578): 1.45e-13: 72.2: 25.71
+	Mm
		1141138 BCR_MOUSE (1-1271): 0: 941: 93.79		GRB2_MOUSE (482-578): 3.54e-15: 76.8: 30.48
+	Hs
		666091 ARHG5_HUMAN (95-862): 8.55e-82: 297: 14.49		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Mm
		57447 ABR_MOUSE (419-1271): 0: 563: 66.00		A2AM67_MOUSE (191-575): 2.18e-43: 162: 14.47
+	Hs
		548628 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		VAV_HUMAN (163-578): 1.81e-54: 200: 12.25
+	Mm
		1206702 ITSN1_MOUSE (74-927): 4.91e-77: 283: 13.61		ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86
+	Hs
		655359 Q13746_HUMAN (56-436): 3.29e-87: 290: 97.38		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		655386 ITSN1_HUMAN (74-927): 1.53e-78: 287: 13.61		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		548645 VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		924658 FGD6_HUMAN (93-969): 1.47e-86: 311: 14.15		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		924525 ARHG5_HUMAN (95-862): 8.55e-82: 297: 14.49		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Mm
		654982 VAV_MOUSE (393-1106): 2.14e-78: 279: 11.78		GRB2_MOUSE (482-578): 3.54e-15: 76.8: 30.48
+	Hs
		924777 Q96D37_HUMAN (393-1092): 1.17e-77: 275: 12.29		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48