Protein: IGKC
Immunoglobulin kappa constant (Ig kappa chain C region) (Ig kappa chain C region AG) (Ig kappa chain C region CUM) (Ig kappa chain C region EU) (Ig kappa chain C region OU) (Ig kappa chain C region ROY) (Ig kappa chain C region TI)

Gene: IGKC
Organism: Homo sapiens
Interactions: 107
UniProt ID: P01834

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0003823 - antigen binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

379057

IGHG1
Immunoglobulin heavy constant gamma 1

3

16

Small-scale

0.834

High

379087

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

2

20

Small-scale

0.754

High

379058

IGHG4
Immunoglobulin heavy constant gamma 4

1

16

Small-scale

0.647

High

132963

MATN2
Matrilin-2

1

9

High-throughput

0.575

High

210646

KLK10
Kallikrein-10

1

16

High-throughput

0.575

High

379059

IGHM
Immunoglobulin heavy constant mu

1

16

High-throughput

0.575

High

379061

ALBU
Albumin

1

4

High-throughput

0.575

High

379071

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

4

High-throughput

0.575

High

379099

FNDC1
Fibronectin type III domain-containing protein 1

1

7

High-throughput

0.575

High

379102

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

10

High-throughput

0.575

High

379118

FNDC5
Fibronectin type III domain-containing protein 5

1

6

High-throughput

0.575

High

379076

CAH8
Carbonic anhydrase-related protein

1

6

High-throughput

0.514

High

379100

LRC10
Leucine-rich repeat-containing protein 10

1

5

High-throughput

0.514

High

379069

ZSC20
Zinc finger and SCAN domain-containing protein 20

2

2

High-throughput

0.504

High

379107

HBM
Hemoglobin subunit mu

2

6

High-throughput

0.504

High

379130

CDK15
Cyclin-dependent kinase 15

2

4

High-throughput

0.504

High

379135

DDX31
ATP-dependent DNA helicase DDX31

2

4

High-throughput

0.504

High

379141

TB22B
TBC1 domain family member 22B

2

4

High-throughput

0.504

High

379092

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

132548

UPK1A
Uroplakin-1a

1

7

High-throughput

0.445

High

141973

FCN1
Ficolin-1

1

3

High-throughput

0.445

High

254714

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

7

High-throughput

0.445

High

351629

SG1D1
Secretoglobin family 1D member 1

1

5

High-throughput

0.445

High

379060

APOA1
Apolipoprotein A-I

1

3

High-throughput

0.445

High

379062

TRFE
Serotransferrin

1

1

High-throughput

0.445

High

379064

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

4

High-throughput

0.445

High

379065

F13B
Coagulation factor XIII B chain

1

4

Small-scale

0.445

High

379066

TAU
Microtubule-associated protein tau

1

1

Small-scale

0.445

High

379068

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.445

High

379070

AATC
Aspartate aminotransferase, cytoplasmic

1

9

High-throughput

0.445

High

379074

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

9

High-throughput

0.445

High

379075

CCR1
C-C chemokine receptor type 1

1

10

High-throughput

0.445

High

379077

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.445

High

379079

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

6

High-throughput

0.445

High

379083

GBG10

1

6

High-throughput

0.445

High

379085

STX17
Syntaxin-17

1

4

High-throughput

0.445

High

379095

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

Small-scale

0.445

High

379110

NT2NA
Notch homolog 2 N-terminal-like protein A

1

2

High-throughput

0.445

High

379122

ITLN2
Intelectin-2

1

4

High-throughput

0.445

High

379126

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

14

High-throughput

0.445

High

379132

EGFL8
Epidermal growth factor-like protein 8

1

8

High-throughput

0.445

High

379146

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

6

High-throughput

0.445

High

379147

DD19B
ATP-dependent RNA helicase DDX19B

1

3

High-throughput

0.445

High

277229

PITX3
Pituitary homeobox 3

1

4

Small-scale

0.437

High

379063

FRIH
Ferritin heavy chain

1

0

High-throughput

0.426

High

379080

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.426

High

379105

RNLS
Renalase

1

0

Small-scale

0.426

High

379119

NPB
Neuropeptide B

1

0

High-throughput

0.426

High

379120

ATS18
A disintegrin and metalloproteinase with thrombospondin motifs 18

1

0

High-throughput

0.426

High

379125

PMEPA
Protein TMEPAI

1

0

High-throughput

0.426

High

379137

S28A3
Solute carrier family 28 member 3

1

0

Small-scale

0.426

High

379078

MLH1
DNA mismatch repair protein Mlh1

1

1

Small-scale

0.417

High

96888

E9PDS3
Integrin subunit alpha 9

1

4

High-throughput

0.407

High

133835

FOXN3
Forkhead box protein N3

1

2

High-throughput

0.407

High

161276

ENC1
Ectoderm-neural cortex protein 1

1

1

High-throughput

0.407

High

231363

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

2

High-throughput

0.407

High

325252

OR2A4
Olfactory receptor 2A4

1

6

High-throughput

0.407

High

379067

ADT3
ADP/ATP translocase 3

1

10

High-throughput

0.407

High

379072

CCNA2
Cyclin-A2

1

2

High-throughput

0.407

High

379073

PO3F3
POU domain, class 3, transcription factor 3

1

1

High-throughput

0.407

High

379081

PTSS1
Phosphatidylserine synthase 1

1

4

High-throughput

0.407

High

379084

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

2

High-throughput

0.407

High

379086

DSCR6
Protein ripply3

1

3

High-throughput

0.407

High

379088

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

2

High-throughput

0.407

High

379089

SSBP2
Single-stranded DNA-binding protein 2

1

5

High-throughput

0.407

High

379090

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

6

High-throughput

0.407

High

379093

EF1A2
Elongation factor 1-alpha 2

1

3

High-throughput

0.407

High

379094

GABPA
GA-binding protein alpha chain

1

2

High-throughput

0.407

High

379097

UPP1
Uridine phosphorylase 1

1

3

High-throughput

0.407

High

379098

CR021
UPF0711 protein C18orf21

1

6

High-throughput

0.407

High

379101

EMC4
ER membrane protein complex subunit 4

1

4

High-throughput

0.407

High

379103

MYOME
Myomegalin

1

2

High-throughput

0.407

High

379104

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

8

High-throughput

0.407

High

379106

ICE2
Little elongation complex subunit 2

1

1

High-throughput

0.407

High

379108

SFXN4
Sideroflexin-4

1

7

High-throughput

0.407

High

379109

ZN550
Zinc finger protein 550

1

2

High-throughput

0.407

High

379111

KHDC4
KH homology domain-containing protein 4

1

1

High-throughput

0.407

High

379112

CIR1
Corepressor interacting with RBPJ 1

1

6

High-throughput

0.407

High

379113

CERS3
Ceramide synthase 3

1

7

High-throughput

0.407

High

379114

NRSN1
Neurensin-1

1

6

High-throughput

0.407

High

379115

RIBC1
RIB43A-like with coiled-coils protein 1

1

1

High-throughput

0.407

High

379117

ASCC1
Activating signal cointegrator 1 complex subunit 1

1

4

High-throughput

0.407

High

379121

RHBL4
Rhomboid-related protein 4

1

7

High-throughput

0.407

High

379123

TANK
TRAF family member-associated NF-kappa-B activator

1

2

High-throughput

0.407

High

379124

PIGT
GPI-anchor transamidase component PIGT

1

6

High-throughput

0.407

High

379128

SARAF
Store-operated calcium entry-associated regulatory factor

1

4

High-throughput

0.407

High

379131

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

12

High-throughput

0.407

High

379133

FUND2
FUN14 domain-containing protein 2

1

2

High-throughput

0.407

High

379134

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.407

High

379136

COE2
Transcription factor COE2

1

4

High-throughput

0.407

High

379138

UD110
UDP-glucuronosyltransferase 1A10

1

5

High-throughput

0.407

High

379140

MBNL1
Muscleblind-like protein 1

1

4

High-throughput

0.407

High

379142

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

1

4

High-throughput

0.407

High

379143

PLK2
Serine/threonine-protein kinase PLK2

1

1

High-throughput

0.407

High

379145

PHF11
PHD finger protein 11

1

7

High-throughput

0.407

High

379148

SSUH2
Protein SSUH2 homolog

1

4

High-throughput

0.407

High

379149

AR2BP
ADP-ribosylation factor-like protein 2-binding protein

1

2

High-throughput

0.407

High

379129

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.249

Low

872

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

280088

SC22B
Vesicle-trafficking protein SEC22b

1

0

High-throughput

0.232

Low

379082

RPIA
Ribose-5-phosphate isomerase

1

0

High-throughput

0.232

Low

379091

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.232

Low

379096

TWF1
Twinfilin-1

1

0

High-throughput

0.232

Low

379116

CCD82
Coiled-coil domain-containing protein 82

1

0

High-throughput

0.232

Low

379127

RNF25
E3 ubiquitin-protein ligase RNF25

1

0

High-throughput

0.232

Low

379139

SHCAF
SIN3-HDAC complex-associated factor

1

0

High-throughput

0.232

Low

379144

SRTD1
SERTA domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025