Protein: IGHG1
Immunoglobulin heavy constant gamma 1 (Ig gamma-1 chain C region) (Ig gamma-1 chain C region EU) (Ig gamma-1 chain C region KOL) (Ig gamma-1 chain C region NIE)

Gene: IGHG1
Organism: Homo sapiens
Interactions: 178
UniProt ID: P01857

Gene Ontology (top 5):
GO:0001788 - antibody-dependent cellular cytotoxicity
GO:0002250 - adaptive immune response
GO:0003823 - antigen binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

379057

IGKC
Immunoglobulin kappa constant

3

16

Small-scale

0.834

High

379198

IGLC1
Immunoglobulin lambda constant 1

2

16

Small-scale

0.755

High

379203

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

6

Small-scale

0.692

High

379219

FCG2B
Low affinity immunoglobulin gamma Fc region receptor II-b

1

8

Small-scale

0.692

High

378779

LV208
Immunoglobulin lambda variable 2-8

1

19

Small-scale

0.647

High

379172

IGHG1
Immunoglobulin heavy constant gamma 1

1

16

Small-scale

0.647

High

379221

CAH8
Carbonic anhydrase-related protein

2

4

High-throughput

0.637

High

62877

POTEF
POTE ankyrin domain family member F

1

5

High-throughput

0.575

High

132964

MATN2
Matrilin-2

1

11

High-throughput

0.575

High

210647

KLK10
Kallikrein-10

1

9

High-throughput

0.575

High

378773

LV147
Immunoglobulin lambda variable 1-47

1

19

High-throughput

0.575

High

378919

HV323
Immunoglobulin heavy variable 3-23

1

15

High-throughput

0.575

High

378922

HV307
Immunoglobulin heavy variable 3-7

1

12

High-throughput

0.575

High

379173

IGHG2
Immunoglobulin heavy constant gamma 2

1

17

High-throughput

0.575

High

379174

IGHG3
Immunoglobulin heavy constant gamma 3

1

17

High-throughput

0.575

High

379175

IGHG4
Immunoglobulin heavy constant gamma 4

1

17

High-throughput

0.575

High

379181

FINC
Fibronectin

1

9

High-throughput

0.575

High

379183

ALBU
Albumin

1

5

High-throughput

0.575

High

379190

HEP2
Heparin cofactor 2

1

1

High-throughput

0.575

High

379192

KLK3
Prostate-specific antigen

1

9

High-throughput

0.575

High

379201

FGFR1
Fibroblast growth factor receptor 1

1

15

High-throughput

0.575

High

379208

IGLL1
Immunoglobulin lambda-like polypeptide 1

1

16

High-throughput

0.575

High

379211

VCAM1
Vascular cell adhesion protein 1

1

6

High-throughput

0.575

High

379215

ZA2G
Zinc-alpha-2-glycoprotein

1

4

High-throughput

0.575

High

379228

SC6A9
Sodium- and chloride-dependent glycine transporter 1

1

2

High-throughput

0.575

High

379254

FNDC1
Fibronectin type III domain-containing protein 1

1

12

High-throughput

0.575

High

379276

Q8N355
IGL@ protein

1

18

High-throughput

0.575

High

379280

FNDC5
Fibronectin type III domain-containing protein 5

1

6

High-throughput

0.575

High

379285

TITIN
Titin

1

17

High-throughput

0.575

High

379305

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

8

High-throughput

0.575

High

379216

1433T
14-3-3 protein theta

2

9

High-throughput

0.552

High

379295

SUSD3
Sushi domain-containing protein 3

2

2

High-throughput

0.552

High

379186

IFNA4
Interferon alpha-4

1

0

High-throughput

0.546

High

379231

FAS
Fatty acid synthase

1

0

High-throughput

0.546

High

379255

LRC10
Leucine-rich repeat-containing protein 10

1

3

High-throughput

0.514

High

379214

CP3A5
Cytochrome P450 3A5

2

1

High-throughput

0.504

High

379279

ASCC1
Activating signal cointegrator 1 complex subunit 1

2

4

High-throughput

0.504

High

379297

CDK15
Cyclin-dependent kinase 15

2

6

High-throughput

0.504

High

379309

DDX31
ATP-dependent DNA helicase DDX31

2

9

High-throughput

0.504

High

379288

H2B1H
Histone H2B type 1-H

1

11

High-throughput

0.479

High

132549

UPK1A
Uroplakin-1a

1

10

High-throughput

0.445

High

193483

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

5

High-throughput

0.445

High

194437

P2RX6
P2X purinoceptor 6

1

4

High-throughput

0.445

High

254715

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.445

High

276879

VPS4B
Vacuolar protein sorting-associated protein 4B

1

3

High-throughput

0.445

High

351630

SG1D1
Secretoglobin family 1D member 1

1

6

High-throughput

0.445

High

379176

K1C14
Keratin, type I cytoskeletal 14

1

11

High-throughput

0.445

High

379177

K2C6A
Keratin, type II cytoskeletal 6A

1

8

High-throughput

0.445

High

379178

APOA1
Apolipoprotein A-I

1

3

High-throughput

0.445

High

379179

APOC1
Apolipoprotein C-I

1

2

High-throughput

0.445

High

379180

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

6

High-throughput

0.445

High

379182

TTHY
Transthyretin

1

1

High-throughput

0.445

High

379184

TRFE
Serotransferrin

1

3

High-throughput

0.445

High

379185

K2C1
Keratin, type II cytoskeletal 1

1

7

High-throughput

0.445

High

379188

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

6

High-throughput

0.445

High

379189

F13B
Coagulation factor XIII B chain

1

5

Small-scale

0.445

High

379193

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

15

High-throughput

0.445

High

379195

K2C7
Keratin, type II cytoskeletal 7

1

4

High-throughput

0.445

High

379196

K1C16
Keratin, type I cytoskeletal 16

1

11

High-throughput

0.445

High

379199

CLUS
Clusterin

1

1

High-throughput

0.445

High

379200

BIP
Endoplasmic reticulum chaperone BiP

1

11

High-throughput

0.445

High

379204

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.445

High

379205

K1C10
Keratin, type I cytoskeletal 10

1

13

High-throughput

0.445

High

379206

K2C5
Keratin, type II cytoskeletal 5

1

5

High-throughput

0.445

High

379207

ELN
Elastin

1

2

High-throughput

0.445

High

379210

AATC
Aspartate aminotransferase, cytoplasmic

1

7

High-throughput

0.445

High

379218

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

11

High-throughput

0.445

High

379220

CCR1
C-C chemokine receptor type 1

1

13

High-throughput

0.445

High

379222

ADA1B
Alpha-1B adrenergic receptor

1

3

High-throughput

0.445

High

379223

K1C9
Keratin, type I cytoskeletal 9

1

12

High-throughput

0.445

High

379226

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

4

High-throughput

0.445

High

379230

TGM4
Protein-glutamine gamma-glutamyltransferase 4

1

1

High-throughput

0.445

High

379232

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.445

High

379233

CAD12
Cadherin-12

1

3

High-throughput

0.445

High

379234

STX17
Syntaxin-17

1

4

High-throughput

0.445

High

379236

1433G
14-3-3 protein gamma

1

9

High-throughput

0.445

High

379241

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

3

Small-scale

0.445

High

379244

PAPP1
Pappalysin-1

1

6

High-throughput

0.445

High

379245

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

7

High-throughput

0.445

High

379246

ICAM4
Intercellular adhesion molecule 4

1

1

High-throughput

0.445

High

379264

GP141
Probable G-protein coupled receptor 141

1

14

High-throughput

0.445

High

379270

FRAS1
Extracellular matrix organizing protein FRAS1

1

6

High-throughput

0.445

High

379274

RTKN2
Rhotekin-2

1

2

High-throughput

0.445

High

379275

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

11

High-throughput

0.445

High

379282

ARI1B
AT-rich interactive domain-containing protein 1B

1

2

High-throughput

0.445

High

379284

ITLN2
Intelectin-2

1

6

High-throughput

0.445

High

379290

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

5

High-throughput

0.445

High

379299

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.445

High

379301

EGFL8
Epidermal growth factor-like protein 8

1

12

High-throughput

0.445

High

379306

OR8D2
Olfactory receptor 8D2

1

2

High-throughput

0.445

High

379319

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

8

High-throughput

0.445

High

379321

DD19B
ATP-dependent RNA helicase DDX19B

1

5

High-throughput

0.445

High

277230

PITX3
Pituitary homeobox 3

1

4

Small-scale

0.437

High

379243

TRAF1
TNF receptor-associated factor 1

1

1

High-throughput

0.437

High

379325

NEMO
NF-kappa-B essential modulator

1

9

High-throughput

0.437

High

361511

CERU
Ceruloplasmin

1

0

High-throughput

0.426

High

379187

APOD
Apolipoprotein D

1

0

High-throughput

0.426

High

379194

CO4A2

1

0

High-throughput

0.426

High

379217

AOAH
Acyloxyacyl hydrolase

1

0

High-throughput

0.426

High

379224

SAA4
Serum amyloid A-4 protein

1

0

High-throughput

0.426

High

379249

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.426

High

379260

HRG1
Heme transporter HRG1

1

0

High-throughput

0.426

High

379307

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

High-throughput

0.426

High

161277

ENC1
Ectoderm-neural cortex protein 1

1

6

High-throughput

0.407

High

231364

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

2

High-throughput

0.407

High

282647

E2F6
Transcription factor E2F6

1

1

High-throughput

0.407

High

283414

TAD2A
Transcriptional adapter 2-alpha

1

1

High-throughput

0.407

High

325253

OR2A4
Olfactory receptor 2A4

1

7

High-throughput

0.407

High

327139

ZFPL1
Zinc finger protein-like 1

1

3

High-throughput

0.407

High

379191

NFM
Neurofilament medium polypeptide

1

8

High-throughput

0.407

High

379202

ADT3
ADP/ATP translocase 3

1

5

High-throughput

0.407

High

379209

ZSC20
Zinc finger and SCAN domain-containing protein 20

1

2

High-throughput

0.407

High

379212

CSK22
Casein kinase II subunit alpha'

1

5

High-throughput

0.407

High

379213

CCNA2
Cyclin-A2

1

2

High-throughput

0.407

High

379227

KI67
Proliferation marker protein Ki-67

1

4

High-throughput

0.407

High

379229

PTSS1
Phosphatidylserine synthase 1

1

4

High-throughput

0.407

High

379235

DSCR6
Protein ripply3

1

3

High-throughput

0.407

High

379237

SSBP2
Single-stranded DNA-binding protein 2

1

5

High-throughput

0.407

High

379238

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

9

High-throughput

0.407

High

379239

EF1A2
Elongation factor 1-alpha 2

1

3

High-throughput

0.407

High

379240

GABPA
GA-binding protein alpha chain

1

2

High-throughput

0.407

High

379242

TRAF2
TNF receptor-associated factor 2

1

3

High-throughput

0.407

High

379248

ABRX2
BRISC complex subunit Abraxas 2

1

1

High-throughput

0.407

High

379250

KAT1
Kynurenine--oxoglutarate transaminase 1

1

10

High-throughput

0.407

High

379251

UPP1
Uridine phosphorylase 1

1

3

High-throughput

0.407

High

379252

RFX7
DNA-binding protein RFX7

1

2

High-throughput

0.407

High

379253

CR021
UPF0711 protein C18orf21

1

7

High-throughput

0.407

High

379256

EMC4
ER membrane protein complex subunit 4

1

3

High-throughput

0.407

High

379257

MYOME
Myomegalin

1

7

High-throughput

0.407

High

379258

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

9

High-throughput

0.407

High

379261

SFXN4
Sideroflexin-4

1

6

High-throughput

0.407

High

379262

CTR9
RNA polymerase-associated protein CTR9 homolog

1

3

High-throughput

0.407

High

379265

PCGF5
Polycomb group RING finger protein 5

1

8

High-throughput

0.407

High

379266

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

3

High-throughput

0.407

High

379268

CIR1
Corepressor interacting with RBPJ 1

1

7

High-throughput

0.407

High

379269

MICU3
Calcium uptake protein 3, mitochondrial

1

2

High-throughput

0.407

High

379271

Z354C
Zinc finger protein 354C

1

1

High-throughput

0.407

High

379272

CERS3
Ceramide synthase 3

1

7

High-throughput

0.407

High

379273

NRSN1
Neurensin-1

1

6

High-throughput

0.407

High

379277

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.407

High

379278

GDPD1
Lysophospholipase D GDPD1

1

3

High-throughput

0.407

High

379283

RHBL4
Rhomboid-related protein 4

1

8

High-throughput

0.407

High

379286

TFG
Protein TFG

1

3

High-throughput

0.407

High

379287

TANK
TRAF family member-associated NF-kappa-B activator

1

2

High-throughput

0.407

High

379289

PIGT
GPI-anchor transamidase component PIGT

1

6

High-throughput

0.407

High

379291

SARAF
Store-operated calcium entry-associated regulatory factor

1

3

High-throughput

0.407

High

379292

F120B
Constitutive coactivator of peroxisome proliferator-activated receptor gamma

1

1

High-throughput

0.407

High

379293

EDC3
Enhancer of mRNA-decapping protein 3

1

1

High-throughput

0.407

High

379294

SMIM8
Small integral membrane protein 8

1

1

High-throughput

0.407

High

379296

SNX27
Sorting nexin-27

1

11

High-throughput

0.407

High

379298

SETB2
Histone-lysine N-methyltransferase SETDB2

1

1

High-throughput

0.407

High

379300

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

11

High-throughput

0.407

High

379302

FUND2
FUN14 domain-containing protein 2

1

2

High-throughput

0.407

High

379303

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

9

High-throughput

0.407

High

379304

SRRT
Serrate RNA effector molecule homolog

1

2

High-throughput

0.407

High

379308

SFR19
Splicing factor, arginine/serine-rich 19

1

2

High-throughput

0.407

High

379310

QTRT2
Queuine tRNA-ribosyltransferase accessory subunit 2

1

1

High-throughput

0.407

High

379311

COE2
Transcription factor COE2

1

6

High-throughput

0.407

High

379312

UD110
UDP-glucuronosyltransferase 1A10

1

1

High-throughput

0.407

High

379313

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

3

High-throughput

0.407

High

379314

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

1

High-throughput

0.407

High

379315

MBNL1
Muscleblind-like protein 1

1

4

High-throughput

0.407

High

379316

TB22B
TBC1 domain family member 22B

1

3

High-throughput

0.407

High

379317

MO4L1
Mortality factor 4-like protein 1

1

2

High-throughput

0.407

High

379318

PHF11
PHD finger protein 11

1

11

High-throughput

0.407

High

379320

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.407

High

379322

SSUH2
Protein SSUH2 homolog

1

4

High-throughput

0.407

High

379323

AR2BP
ADP-ribosylation factor-like protein 2-binding protein

1

2

High-throughput

0.407

High

379324

RN115
E3 ubiquitin-protein ligase RNF115

1

4

High-throughput

0.407

High

318184

DDHD2
Triacylglycerol hydrolase DDHD2

1

0

High-throughput

0.232

Low

379197

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.232

Low

379225

NU214
Nuclear pore complex protein Nup214

1

0

High-throughput

0.232

Low

379247

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.232

Low

379259

TENS3
Tensin-3

1

0

High-throughput

0.232

Low

379263

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

0

High-throughput

0.232

Low

379267

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.232

Low

379281

ARMC2
Armadillo repeat-containing protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025