HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	7559490, 18022941
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0001525 - angiogenesis GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 583
+	Hs
		601467 FGFR2_HUMAN (1-821): 0: 803: 71.21		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		607889 FGFR4_HUMAN (29-808): 0: 664: 55.60		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		507999 FGFR1_HUMAN (1-822): 0: 861: 100.00		GRB14_HUMAN (66-579): 1.66e-73: 246: 14.41
+	Hs
		507829 FGFR1_HUMAN (1-822): 0: 861: 100.00		VAV_HUMAN (163-578): 1.81e-54: 200: 12.25
+	Hs
		208983 FGFR1_HUMAN (1-822): 0: 861: 100.00		NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83
+	Hs
		508019 FGFR1_HUMAN (1-822): 0: 861: 100.00		SHB_HUMAN (369-579): 2.01e-41: 158: 20.63
+	Hs
		507832 FGFR1_HUMAN (1-822): 0: 861: 100.00		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		507870 FGFR1_HUMAN (1-822): 0: 861: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		508058 FGFR1_HUMAN (1-822): 0: 861: 100.00		SHE_HUMAN (357-583): 9.82e-38: 148: 21.40
+	Hs
		129184 FGFR1_HUMAN (1-822): 0: 861: 100.00		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		601463 FGFR2_HUMAN (1-821): 0: 803: 71.21		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		507939 FGFR1_HUMAN (1-822): 0: 861: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		129199 FGFR2_HUMAN (1-821): 0: 803: 71.21		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		609182 FGFR3_HUMAN (6-821): 0: 730: 61.22		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		601492 FGFR2_HUMAN (1-821): 0: 803: 71.21		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		208993 FGFR4_HUMAN (29-808): 0: 664: 55.60		NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83
+	Hs
		557606 FGFR4_HUMAN (29-808): 0: 664: 55.60		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		607886 FGFR4_HUMAN (29-808): 0: 664: 55.60		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		609244 FGFR3_HUMAN (6-821): 0: 730: 61.22		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		129201 FGFR4_HUMAN (29-808): 0: 664: 55.60		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47