Protein: SYNE2
Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2)

Gene: SYNE2
Organism: Homo sapiens
Interactions: 196
UniProt ID: Q8WXH0

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0003779 - actin binding
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005640 - nuclear outer membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1360691

SUN2
SUN domain-containing protein 2

6

13

Small-scale

0.955

High

1252154

SYNE3
Nesprin-3

2

20

Small-scale

0.737

High

321014

SUN1
SUN domain-containing protein 1

1

13

Small-scale

0.730

High

1360689

VAPA
Vesicle-associated membrane protein-associated protein A

3

4

High-throughput

0.662

High

1138441

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

3

4

High-throughput

0.650

High

995725

ACTC
Actin, alpha cardiac muscle 1

1

20

Small-scale

0.647

High

508349

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

9

Small-scale

0.646

High

333120

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

4

High-throughput

0.628

High

691806

MK03
Mitogen-activated protein kinase 3

2

6

Small-scale

0.624

High

703665

MK01
Mitogen-activated protein kinase 1

2

6

Small-scale

0.624

High

1117424

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

High-throughput

0.618

High

1254840

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.618

High

1360696

ALK
ALK tyrosine kinase receptor

1

18

High-throughput

0.618

High

965797

HNRPK
Heterogeneous nuclear ribonucleoprotein K

3

0

High-throughput

0.613

High

1360702

CAN6
Calpain-6

2

0

High-throughput

0.602

High

894939

EMD
Emerin

2

3

Small-scale

0.601

High

1278913

BRAP
BRCA1-associated protein

2

7

Small-scale

0.595

High

1360655

LRC59
Leucine-rich repeat-containing protein 59

2

11

High-throughput

0.584

High

975834

RL7A
Large ribosomal subunit protein eL8

2

0

High-throughput

0.576

High

1338560

SYNE1
Nesprin-1

1

17

Small-scale

0.575

High

138513

BIN1
Myc box-dependent-interacting protein 1

1

8

Small-scale

0.573

High

631377

RAB5A
Ras-related protein Rab-5A

2

10

High-throughput

0.571

High

714301

PML
Protein PML

1

7

Small-scale

0.561

High

764920

CTNB1
Catenin beta-1

1

7

Small-scale

0.561

High

1024116

TFAM
Transcription factor A, mitochondrial

2

0

High-throughput

0.559

High

904037

BAP31
B-cell receptor-associated protein 31

2

1

High-throughput

0.558

High

1210931

CE170
Centrosomal protein of 170 kDa

2

16

High-throughput

0.558

High

1316684

ABI1
Abl interactor 1

1

11

High-throughput

0.541

High

1360694

DP13A
DCC-interacting protein 13-alpha

1

2

High-throughput

0.541

High

130558

SPT5H
Transcription elongation factor SPT5

1

4

High-throughput

0.536

High

209309

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

6

High-throughput

0.536

High

361318

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

574030

HXB2
Homeobox protein Hox-B2

1

1

High-throughput

0.536

High

686845

S10A4
Protein S100-A4

1

3

High-throughput

0.536

High

732657

ARRB2
Beta-arrestin-2

1

2

High-throughput

0.536

High

789186

NUP62
Nuclear pore glycoprotein p62

1

10

High-throughput

0.536

High

927455

ATX1
Ataxin-1

1

1

High-throughput

0.536

High

1109938

HDAC1
Histone deacetylase 1

1

10

High-throughput

0.536

High

1121641

MORC3
MORC family CW-type zinc finger protein 3

1

2

High-throughput

0.536

High

1158451

CDC37
Hsp90 co-chaperone Cdc37

1

1

High-throughput

0.536

High

1360657

HDA11
Histone deacetylase 11

1

11

High-throughput

0.536

High

1360682

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.536

High

1360692

FBX2
F-box only protein 2

1

1

High-throughput

0.536

High

1360664

SEC62
Translocation protein SEC62

2

3

High-throughput

0.533

High

1360701

FHOD1
FH1/FH2 domain-containing protein 1

1

3

Small-scale

0.529

High

125774

STXB3
Syntaxin-binding protein 3

1

6

High-throughput

0.515

High

447261

NPM
Nucleophosmin

1

1

High-throughput

0.515

High

535352

BIP
Endoplasmic reticulum chaperone BiP

1

10

High-throughput

0.515

High

1008259

PRKDC
DNA-dependent protein kinase catalytic subunit

1

5

High-throughput

0.515

High

1232490

Q6FHY5
MEOX2 protein

1

3

High-throughput

0.515

High

231400

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

0

High-throughput

0.513

High

282991

FRAT2
GSK-3-binding protein FRAT2

1

0

High-throughput

0.513

High

1215559

RNH2B
Ribonuclease H2 subunit B

1

0

High-throughput

0.513

High

1312805

NRM
Nurim

1

0

High-throughput

0.513

High

1103717

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

5

High-throughput

0.508

High

827864

STAT3
Signal transducer and activator of transcription 3

1

5

High-throughput

0.500

High

270164

LRP3
Low-density lipoprotein receptor-related protein 3

1

4

High-throughput

0.489

High

701420

5HT1B
5-hydroxytryptamine receptor 1B

1

4

High-throughput

0.489

High

1331396

GBP7
Guanylate-binding protein 7

1

2

High-throughput

0.489

High

1349062

TBC16
TBC1 domain family member 16

1

1

High-throughput

0.489

High

320402

SASH1
SAM and SH3 domain-containing protein 1

1

2

Small-scale

0.481

High

894057

MEOX2
Homeobox protein MOX-2

1

3

High-throughput

0.481

High

126722

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

138249

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

5

High-throughput

0.479

High

164032

NDC80
Kinetochore protein NDC80 homolog

1

17

High-throughput

0.479

High

174018

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

3

High-throughput

0.479

High

188951

TMPS2
Transmembrane protease serine 2

1

6

High-throughput

0.479

High

189746

STX7
Syntaxin-7

1

7

High-throughput

0.479

High

242429

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.479

High

272351

OBSL1
Obscurin-like protein 1

1

20

High-throughput

0.479

High

291461

NU155
Nuclear pore complex protein Nup155

1

3

High-throughput

0.479

High

331190

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

337963

CNEP1
CTD nuclear envelope phosphatase 1

1

2

High-throughput

0.479

High

386033

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

11

Small-scale

0.479

High

390699

TFR1
Transferrin receptor protein 1

1

4

High-throughput

0.479

High

404270

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

414302

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

459698

PROF1
Profilin-1

1

2

High-throughput

0.479

High

466388

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

472333

CFAH
Complement factor H

1

5

Small-scale

0.479

High

537607

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

562273

LAMP2
Lysosome-associated membrane glycoprotein 2

1

11

High-throughput

0.479

High

573187

KPYM
Pyruvate kinase PKM

1

1

High-throughput

0.479

High

580667

AMPN
Aminopeptidase N

1

2

High-throughput

0.479

High

581201

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

604130

CXA1
Gap junction alpha-1 protein

1

12

High-throughput

0.479

High

611258

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

5

High-throughput

0.479

High

630596

RAB3B
Ras-related protein Rab-3B

1

4

High-throughput

0.479

High

630912

RAB4A
Ras-related protein Rab-4A

1

9

High-throughput

0.479

High

791583

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

837753

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

880629

LMAN1
Protein ERGIC-53

1

5

High-throughput

0.479

High

901434

RAB7A
Ras-related protein Rab-7a

1

10

High-throughput

0.479

High

901974

RAB9A
Ras-related protein Rab-9A

1

14

High-throughput

0.479

High

928502

TERF1
Telomeric repeat-binding factor 1

1

11

High-throughput

0.479

High

955424

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

958577

TM258
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258

1

3

Small-scale

0.479

High

962325

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

966680

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

976454

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.479

High

990548

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

1004147

CXAR
Coxsackievirus and adenovirus receptor

1

5

High-throughput

0.479

High

1015637

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1027109

REEP5
Receptor expression-enhancing protein 5

1

2

High-throughput

0.479

High

1049619

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1058556

CKAP4
Cytoskeleton-associated protein 4

1

20

High-throughput

0.479

High

1087221

STX4
Syntaxin-4

1

7

High-throughput

0.479

High

1111628

STIM1
Stromal interaction molecule 1

1

4

High-throughput

0.479

High

1125575

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

3

High-throughput

0.479

High

1135009

CUL7
Cullin-7

1

9

High-throughput

0.479

High

1141827

EEA1
Early endosome antigen 1

1

20

High-throughput

0.479

High

1145040

RAB35
Ras-related protein Rab-35

1

10

High-throughput

0.479

High

1149943

TERF2
Telomeric repeat-binding factor 2

1

11

High-throughput

0.479

High

1242484

NFRKB
Nuclear factor related to kappa-B-binding protein

1

4

High-throughput

0.479

High

1286847

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.479

High

1314664

SRRM1
Serine/arginine repetitive matrix protein 1

1

8

High-throughput

0.479

High

1333924

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.479

High

1337613

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.479

High

1338868

NUP43
Nucleoporin Nup43

1

10

High-throughput

0.479

High

1360652

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1360653

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

2

High-throughput

0.479

High

1360656

OPTN
Optineurin

1

20

High-throughput

0.479

High

1360659

DNJC1
DnaJ homolog subfamily C member 1

1

12

High-throughput

0.479

High

1360663

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

2

High-throughput

0.479

High

1360667

LNP
Endoplasmic reticulum junction formation protein lunapark

1

2

High-throughput

0.479

High

1360670

VP33B
Vacuolar protein sorting-associated protein 33B

1

7

High-throughput

0.479

High

1360671

GAN
Gigaxonin

1

8

High-throughput

0.479

High

1360677

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

10

High-throughput

0.479

High

1360680

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.479

High

1360684

MKS1
Tectonic-like complex member MKS1

1

1

Small-scale

0.479

High

1360685

TRM1
tRNA

1

1

High-throughput

0.479

High

1360688

CHMP5
Charged multivesicular body protein 5

1

15

High-throughput

0.479

High

1360700

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

2

Small-scale

0.479

High

1131205

MESD
LRP chaperone MESD

1

1

High-throughput

0.470

High

1294603

CONA1

1

2

High-throughput

0.470

High

880944

MTR1B
Melatonin receptor type 1B

1

10

High-throughput

0.464

High

278917

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

460602

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

0

High-throughput

0.458

High

548356

CP2C9
Cytochrome P450 2C9

1

0

High-throughput

0.458

High

643529

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.458

High

961788

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.458

High

1026480

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1214534

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1360654

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.458

High

1360675

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1360683

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

1360686

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.458

High

239426

3BP5
SH3 domain-binding protein 5

1

3

High-throughput

0.457

High

530133

TAU
Microtubule-associated protein tau

1

13

High-throughput

0.457

High

1351565

MIPT3
TRAF3-interacting protein 1

1

7

High-throughput

0.457

High

1360661

CEP63
Centrosomal protein of 63 kDa

1

20

High-throughput

0.457

High

1360665

CDC5L
Cell division cycle 5-like protein

1

6

High-throughput

0.457

High

1360668

NDEL1
Nuclear distribution protein nudE-like 1

1

20

High-throughput

0.457

High

1360678

DISC1
Disrupted in schizophrenia 1 protein

1

9

High-throughput

0.457

High

1360681

EXOC1
Exocyst complex component 1

1

3

High-throughput

0.457

High

1360693

TNIK
TRAF2 and NCK-interacting protein kinase

1

20

High-throughput

0.457

High

166369

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

2

High-throughput

0.445

High

430174

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

942781

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

18

High-throughput

0.445

High

1337884

ZNT7
Zinc transporter 7

1

2

High-throughput

0.445

High

1360651

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.445

High

48721

ESYT2
Extended synaptotagmin-2

1

2

High-throughput

0.437

High

157676

CTRO
Citron Rho-interacting kinase

1

16

High-throughput

0.437

High

318836

RHBT1
Rho-related BTB domain-containing protein 1

1

20

High-throughput

0.437

High

417630

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.437

High

418309

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

3

High-throughput

0.437

High

847626

SSRA
Translocon-associated protein subunit alpha

1

3

High-throughput

0.437

High

910149

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.437

High

951303

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.437

High

1322920

CXD3
Gap junction delta-3 protein

1

12

High-throughput

0.437

High

1352323

RHBL4
Rhomboid-related protein 4

1

3

High-throughput

0.437

High

1360650

CLC4D
C-type lectin domain family 4 member D

1

6

High-throughput

0.437

High

1360666

DERL1
Derlin-1

1

1

High-throughput

0.437

High

1360669

DJC25
DnaJ homolog subfamily C member 25

1

7

High-throughput

0.437

High

1360672

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.437

High

1360673

TMT1A
Thiol S-methyltransferase TMT1A

1

3

High-throughput

0.437

High

1360674

ANM8
Protein arginine N-methyltransferase 8

1

6

Small-scale

0.437

High

1360676

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.437

High

1360679

TMPS4
Transmembrane protease serine 4

1

6

High-throughput

0.437

High

1360687

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.437

High

1360690

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.437

High

1360695

CLC4E
C-type lectin domain family 4 member E

1

6

High-throughput

0.437

High

1360697

LAMP3
Lysosome-associated membrane glycoprotein 3

1

11

High-throughput

0.437

High

1360698

DJC16
DnaJ homolog subfamily C member 16

1

11

High-throughput

0.437

High

1360658

SAAL1
Protein SAAL1

1

0

High-throughput

0.426

High

1155168

EREP1
Endosomal transmembrane epsin interactor 1

1

1

Small-scale

0.417

High

142382

PEX7
Peroxisomal targeting signal 2 receptor

1

8

High-throughput

0.407

High

466944

ACM4
Muscarinic acetylcholine receptor M4

1

5

High-throughput

0.407

High

1219524

ANR22
Ankyrin repeat domain-containing protein 22

1

20

High-throughput

0.407

High

1227159

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.407

High

1360660

C170L
Cep170-like protein

1

3

High-throughput

0.407

High

1204881

MKS3
Meckelin

1

0

Small-scale

0.292

High

1219456

SLX4I
Protein SLX4IP

1

0

High-throughput

0.279

Low

1292395

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.249

Low

1360662

PANX1
Pannexin-1

1

0

High-throughput

0.249

Low

1360699

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025