Protein: PEPL
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)

Gene: PEPL, PPL
Organism: Homo sapiens
Interactions: 176
UniProt ID: O60437

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0005198 - structural molecule activity
GO:0005200 - structural constituent of cytoskeleton
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

248656

VIME
Vimentin

3

20

Small-scale

0.680

High

248696

TRAF2
TNF receptor-associated factor 2

3

14

High-throughput

0.675

High

248705

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

6

High-throughput

0.667

High

248758

SUSD3
Sushi domain-containing protein 3

3

1

High-throughput

0.667

High

248773

RBM24
RNA-binding protein 24

3

10

High-throughput

0.667

High

248707

RBP1
RalA-binding protein 1

3

13

High-throughput

0.665

High

248675

AKT1
RAC-alpha serine/threonine-protein kinase

2

20

Small-scale

0.649

High

248725

PKHA7
Pleckstrin homology domain-containing family A member 7

3

20

High-throughput

0.647

High

248663

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

3

0

High-throughput

0.646

High

248762

RAB3I
Rab-3A-interacting protein

3

0

High-throughput

0.646

High

248653

FRIH
Ferritin heavy chain

2

1

High-throughput

0.628

High

248737

CCYL1
Cyclin-Y-like protein 1

2

1

High-throughput

0.628

High

248738

FRMD1
FERM domain-containing protein 1

2

20

High-throughput

0.628

High

248760

CDK15
Cyclin-dependent kinase 15

2

17

High-throughput

0.628

High

248645

ANXA9
Annexin A9

2

9

Small-scale

0.621

High

248741

ZSCA1
Zinc finger and SCAN domain-containing protein 1

3

14

High-throughput

0.616

High

248724

K1C39
Keratin, type I cytoskeletal 39

2

20

High-throughput

0.615

High

248719

MYOME
Myomegalin

2

18

High-throughput

0.611

High

248800

DD19B
ATP-dependent RNA helicase DDX19B

2

8

High-throughput

0.611

High

248668

ZSC20
Zinc finger and SCAN domain-containing protein 20

3

5

High-throughput

0.609

High

248785

UD110
UDP-glucuronosyltransferase 1A10

3

2

High-throughput

0.609

High

248670

DESM
Desmin

2

20

High-throughput

0.606

High

248700

IKZF1
DNA-binding protein Ikaros

2

5

High-throughput

0.606

High

248730

K1C25
Keratin, type I cytoskeletal 25

2

18

High-throughput

0.606

High

248783

ARP5
Actin-related protein 5

2

20

High-throughput

0.606

High

248789

PICK1
PRKCA-binding protein

2

1

High-throughput

0.606

High

248680

HD
Huntingtin

2

9

High-throughput

0.596

High

248748

EVPL
Envoplakin

2

19

Small-scale

0.584

High

248787

ANLN
Anillin

2

15

High-throughput

0.584

High

248698

RM28
Large ribosomal subunit protein bL28m

2

0

High-throughput

0.580

High

248746

POF1B
Protein POF1B

2

0

High-throughput

0.580

High

248752

UPP
Uracil phosphoribosyltransferase homolog

2

0

High-throughput

0.580

High

248804

SKAP
Small kinetochore-associated protein

2

0

High-throughput

0.580

High

248782

ACAD9
Complex I assembly factor ACAD9, mitochondrial

2

4

High-throughput

0.574

High

248791

TB22B
TBC1 domain family member 22B

2

6

High-throughput

0.574

High

248802

FCF1
rRNA-processing protein FCF1 homolog

2

3

High-throughput

0.574

High

248721

KAZRN
Kazrin

1

2

Small-scale

0.573

High

248665

TRI27
Zinc finger protein RFP

1

11

High-throughput

0.573

High

248803

T22D4
TSC22 domain family protein 4

1

4

High-throughput

0.573

High

248664

CFTR
Cystic fibrosis transmembrane conductance regulator

2

17

High-throughput

0.571

High

248706

KPCD1
Serine/threonine-protein kinase D1

2

18

High-throughput

0.571

High

163484

ZN213
Zinc finger protein 213

2

7

High-throughput

0.553

High

171817

ZN263
Zinc finger protein 263

2

5

High-throughput

0.553

High

248684

ZN165
Zinc finger protein 165

2

5

High-throughput

0.553

High

248713

KCD21
BTB/POZ domain-containing protein KCTD21

2

20

High-throughput

0.553

High

248717

CF141
Uncharacterized protein C6orf141

2

3

High-throughput

0.553

High

248718

HECD3
E3 ubiquitin-protein ligase HECTD3

2

20

High-throughput

0.553

High

248777

PBX4
Pre-B-cell leukemia transcription factor 4

2

6

High-throughput

0.553

High

248780

ZSC16
Zinc finger and SCAN domain-containing protein 16

2

8

High-throughput

0.553

High

248786

ZBT26
Zinc finger and BTB domain-containing protein 26

2

5

High-throughput

0.553

High

248733

ZC3C1
Zinc finger C3HC-type protein 1

2

3

High-throughput

0.549

High

229908

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

0

High-throughput

0.549

High

248734

CE57L
Centrosomal protein CEP57L1

1

0

High-throughput

0.549

High

137495

BT3A1
Butyrophilin subfamily 3 member A1

1

10

Small-scale

0.543

High

132539

UPK1A
Uroplakin-1a

1

9

High-throughput

0.536

High

194427

P2RX6
P2X purinoceptor 6

1

1

High-throughput

0.536

High

248641

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

11

High-throughput

0.536

High

248643

ECI2
Enoyl-CoA delta isomerase 2

1

3

High-throughput

0.536

High

248644

BODG
Gamma-butyrobetaine dioxygenase

1

1

High-throughput

0.536

High

248646

OR2A4
Olfactory receptor 2A4

1

4

High-throughput

0.536

High

248647

UBR5
E3 ubiquitin-protein ligase UBR5

1

18

High-throughput

0.536

High

248650

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

20

High-throughput

0.536

High

248652

HERC2
E3 ubiquitin-protein ligase HERC2

1

20

High-throughput

0.536

High

248659

ADT3
ADP/ATP translocase 3

1

2

High-throughput

0.536

High

248669

AATC
Aspartate aminotransferase, cytoplasmic

1

4

High-throughput

0.536

High

248673

ITPI2
Protein ITPRID2

1

2

High-throughput

0.536

High

248676

CCR1
C-C chemokine receptor type 1

1

8

High-throughput

0.536

High

248683

PTSS1
Phosphatidylserine synthase 1

1

3

High-throughput

0.536

High

248686

STX17
Syntaxin-17

1

3

High-throughput

0.536

High

248690

SSBP2
Single-stranded DNA-binding protein 2

1

5

High-throughput

0.536

High

248691

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

4

High-throughput

0.536

High

248692

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

1

High-throughput

0.536

High

248694

HSF2
Heat shock factor protein 2

1

3

High-throughput

0.536

High

248695

AHNK
Neuroblast differentiation-associated protein AHNAK

1

11

High-throughput

0.536

High

248701

CUL1
Cullin-1

1

18

High-throughput

0.536

High

248703

ITPR2
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2

1

9

High-throughput

0.536

High

248704

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

9

High-throughput

0.536

High

248709

STK11
Serine/threonine-protein kinase STK11

1

5

High-throughput

0.536

High

248712

MA7D1
MAP7 domain-containing protein 1

1

20

High-throughput

0.536

High

248740

FNDC5
Fibronectin type III domain-containing protein 5

1

4

High-throughput

0.536

High

248750

PIGT
GPI-anchor transamidase component PIGT

1

1

High-throughput

0.536

High

248751

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

2

High-throughput

0.536

High

248756

CLMN
Calmin

1

20

High-throughput

0.536

High

248765

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.536

High

248769

PXL2A
Peroxiredoxin-like 2A

1

1

High-throughput

0.536

High

248774

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

17

High-throughput

0.536

High

248775

SRRT
Serrate RNA effector molecule homolog

1

1

High-throughput

0.536

High

248778

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

20

High-throughput

0.536

High

248781

SYNCI
Syncoilin

1

20

High-throughput

0.536

High

248788

MBNL1
Muscleblind-like protein 1

1

3

High-throughput

0.536

High

248793

KLH11
Kelch-like protein 11

1

6

High-throughput

0.536

High

248797

MTUS1
Microtubule-associated tumor suppressor 1

1

19

High-throughput

0.536

High

248801

SSUH2
Protein SSUH2 homolog

1

2

High-throughput

0.536

High

248806

RN115
E3 ubiquitin-protein ligase RNF115

1

5

High-throughput

0.536

High

248807

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

20

High-throughput

0.536

High

248655

K2C8
Keratin, type II cytoskeletal 8

1

12

Small-scale

0.527

High

248685

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

2

High-throughput

0.515

High

248671

SPR1B
Cornifin-B

1

0

High-throughput

0.513

High

248767

TREX2
Three prime repair exonuclease 2

1

0

High-throughput

0.513

High

248790

TNR19
Tumor necrosis factor receptor superfamily member 19

1

0

High-throughput

0.513

High

248661

SKIL
Ski-like protein

1

3

High-throughput

0.508

High

248749

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

20

High-throughput

0.508

High

248658

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

16

High-throughput

0.501

High

248689

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

6

Small-scale

0.501

High

248667

FOSL1
Fos-related antigen 1

1

1

High-throughput

0.489

High

248687

DSCR6
Protein ripply3

1

1

High-throughput

0.489

High

248711

CR021
UPF0711 protein C18orf21

1

3

High-throughput

0.489

High

248714

FNDC1
Fibronectin type III domain-containing protein 1

1

13

High-throughput

0.489

High

248732

BPHL
Serine hydrolase BPHL

1

1

High-throughput

0.489

High

248753

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

248754

SGF29
SAGA-associated factor 29

1

3

High-throughput

0.489

High

248755

NEUL4
Neuralized-like protein 4

1

3

High-throughput

0.489

High

248757

F167A
Protein FAM167A

1

1

High-throughput

0.489

High

248759

F227B
Protein FAM227B

1

1

High-throughput

0.489

High

248761

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.489

High

248770

MMTA2
Multiple myeloma tumor-associated protein 2

1

1

High-throughput

0.489

High

248784

COE2
Transcription factor COE2

1

1

High-throughput

0.489

High

248796

PHF11
PHD finger protein 11

1

9

High-throughput

0.489

High

248798

COR1C
Coronin-1C

1

20

High-throughput

0.489

High

248708

ITSN1
Intersectin-1

1

14

High-throughput

0.481

High

248799

COHA1
Collagen alpha-1(XVII) chain

1

2

Small-scale

0.481

High

248649

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

248651

PCNT
Pericentrin

1

20

High-throughput

0.479

High

248657

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

13

High-throughput

0.479

High

248662

CADH1
Cadherin-1

1

12

High-throughput

0.479

High

248666

EZRI
Ezrin

1

20

Small-scale

0.479

High

248672

CBL
E3 ubiquitin-protein ligase CBL

1

13

High-throughput

0.479

High

248679

TRI23
E3 ubiquitin-protein ligase TRIM23

1

9

High-throughput

0.479

High

248681

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.479

High

248682

SOX2
Transcription factor SOX-2

1

14

High-throughput

0.479

High

248688

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.479

High

248697

FLII
Protein flightless-1 homolog

1

14

High-throughput

0.479

High

248699

BT1A1
Butyrophilin subfamily 1 member A1

1

11

Small-scale

0.479

High

248702

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.479

High

248710

RBBP7
Histone-binding protein RBBP7

1

18

High-throughput

0.479

High

248723

RNF43
E3 ubiquitin-protein ligase RNF43

1

12

High-throughput

0.479

High

248735

SYNPO
Synaptopodin

1

18

High-throughput

0.479

High

248736

WDTC1
WD and tetratricopeptide repeats protein 1

1

20

High-throughput

0.479

High

248739

NKAI3
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3

1

3

High-throughput

0.479

High

248742

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

248768

FYCO1
FYVE and coiled-coil domain-containing protein 1

1

19

High-throughput

0.479

High

248772

RBM4
RNA-binding protein 4

1

7

High-throughput

0.479

High

248776

FACD2
Fanconi anemia group D2 protein

1

14

High-throughput

0.479

High

248779

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

248792

DCA13
DDB1- and CUL4-associated factor 13

1

17

High-throughput

0.479

High

248795

WRP73
WD repeat-containing protein WRAP73

1

20

High-throughput

0.479

High

248805

LOXL2
Lysyl oxidase homolog 2

1

10

High-throughput

0.479

High

248648

LETM1
Mitochondrial proton/calcium exchanger protein

1

1

High-throughput

0.470

High

248743

PPHLN
Periphilin-1

1

0

Small-scale

0.460

High

248715

DCA17
DDB1- and CUL4-associated factor 17

1

0

High-throughput

0.458

High

248720

ZN318
Zinc finger protein 318

1

0

High-throughput

0.458

High

138418

BIN1
Myc box-dependent-interacting protein 1

1

11

High-throughput

0.457

High

248674

BKRB2
B2 bradykinin receptor

1

8

Small-scale

0.457

High

47440

A0A6Q8PFP9
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein

1

3

High-throughput

0.445

High

248642

NSMA
Sphingomyelin phosphodiesterase 2

1

3

High-throughput

0.445

High

248677

BMI1
Polycomb complex protein BMI-1

1

20

High-throughput

0.445

High

248722

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.445

High

248727

OLFM4
Olfactomedin-4

1

2

High-throughput

0.445

High

248764

MYCBP
c-Myc-binding protein

1

1

High-throughput

0.445

High

248766

PKP2
Plakophilin-2

1

20

High-throughput

0.445

High

248654

MYCN
N-myc proto-oncogene protein

1

18

High-throughput

0.437

High

248716

DCA10
DDB1- and CUL4-associated factor 10

1

20

High-throughput

0.437

High

248731

WDR5B
WD repeat-containing protein 5B

1

20

High-throughput

0.437

High

248744

DCA11
DDB1- and CUL4-associated factor 11

1

15

High-throughput

0.437

High

248745

SNX29
Sorting nexin-29

1

4

High-throughput

0.437

High

248747

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

248763

INT14
Integrator complex subunit 14

1

2

High-throughput

0.437

High

248808

STYL1
Serine/threonine/tyrosine-interacting-like protein 1

1

10

High-throughput

0.437

High

248660

BMP4
Bone morphogenetic protein 4

1

2

High-throughput

0.407

High

248678

RFC4
Replication factor C subunit 4

1

3

High-throughput

0.407

High

248728

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

2

High-throughput

0.407

High

248771

RSRP1
Arginine/serine-rich protein 1

1

1

High-throughput

0.407

High

248794

CLDN1
Claudin domain-containing protein 1

1

1

High-throughput

0.407

High

248726

ZN474
Zinc finger protein 474

2

0

High-throughput

0.316

High

248729

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.279

Low

248693

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025