HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: H2A2A (Q6FI13)
Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o)
Gene: H2AC18

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	28190767, 25253489
Identification Methods	pull down, cross-linking study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Histone~ubiquitin, Histone_H2A_C~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 130
+	Hs
		418800 UBC_HUMAN (1-685): 0: 857: 100.00		H2A1B_HUMAN (1-130): 8.1e-67: 199: 96.92
+	Hs
		508511 UBC_HUMAN (1-685): 0: 857: 100.00		H2A1J_HUMAN (1-128): 2.25e-66: 198: 97.66
+	Hs
		508471 UBC_HUMAN (1-685): 0: 857: 100.00		H2A1A_HUMAN (1-125): 7.34e-66: 197: 95.20
+	Hs
		508052 UBC_HUMAN (1-685): 0: 857: 100.00		H2A2C_HUMAN (1-128): 2.25e-64: 193: 96.88
+	Hs
		507499 UBC_HUMAN (1-685): 0: 857: 100.00		H2AX_HUMAN (1-130): 3.31e-63: 190: 88.81
+	Rn
		506193 UBC_RAT (1-637): 0: 779: 98.90		H2A2A_RAT (1-130): 3.68e-67: 200: 100.00
+	Sc
		419554 UBI4P_YEAST (381-685): 4.09e-126: 380: 95.74		H2A2_YEAST (16-127): 2.99e-53: 165: 81.25
+	At
		1168034 UBQ3_ARATH (457-685): 4e-89: 282: 95.63		H2A6_ARATH (1-128): 3.21e-59: 180: 71.32
+	Dm
		1014848 R9PY16_DROME (457-685): 1.03e-83: 268: 90.39		H2A_DROME (17-125): 2.71e-59: 180: 89.91
+	Hs
		502302 RS27A_HUMAN (609-684): 7.26e-41: 148: 100.00		H2A1_HUMAN (1-130): 5.11e-67: 200: 98.46
+	Hs
		987073 RS27A_HUMAN (609-684): 7.26e-41: 148: 100.00		H2A2A_HUMAN (1-130): 3.68e-67: 200: 100.00
+	Hs
		987089 RS27A_HUMAN (609-684): 7.26e-41: 148: 100.00		H2A3_HUMAN (1-130): 5.52e-67: 200: 97.69
+	Hs
		418929 RS27A_HUMAN (609-684): 7.26e-41: 148: 100.00		H2A1B_HUMAN (1-130): 8.1e-67: 199: 96.92
+	Hs
		987098 RS27A_HUMAN (609-684): 7.26e-41: 148: 100.00		H2A2B_HUMAN (1-130): 1.28e-65: 196: 94.62
+	Hs
		591587 RS27A_HUMAN (609-684): 7.26e-41: 148: 100.00		H2AX_HUMAN (1-130): 3.31e-63: 190: 88.81
+	Hs
		507067 UBB_HUMAN (1-77): 1.15e-26: 110: 98.70		H2AX_HUMAN (1-130): 3.31e-63: 190: 88.81
+	Hs
		502364 OASL_HUMAN (357-525): 2.61e-16: 84.4: 29.31		H2A1_HUMAN (1-130): 5.11e-67: 200: 98.46