HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: KI67 (P46013)
Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)
Gene: MKI67

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	15848144
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 2 others more... GO:0005694 - chromosome GO:0005730 - nucleolus
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 3256
+	Hs
		801197 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		KI67_HUMAN (1-3256): 0: 1046: 100.00
+	Hs
		508777 TOP1_HUMAN (1-765): 0: 932: 100.00		SRRM2_HUMAN (1748-3241): 1.64e-18: 96: 8.53
+	Hs
		508571 TOP1_HUMAN (1-765): 0: 932: 100.00		NIPBL_HUMAN (2321-3191): 7.29e-12: 74.4: 12.83
+	Hs
		1154038 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		NIPBL_HUMAN (2321-3191): 7.29e-12: 74.4: 12.83