HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: TRIM5 (Q9C035)
Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)
Gene: TRIM5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	22078707
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_UBOX
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 229 Hs			1 493
+	Hs
		508576 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		TRIM5_HUMAN (1-493): 3.55e-148: 434: 100.00
+	Hs
		507515 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		RO52_HUMAN (1-492): 7.41e-137: 405: 39.80
+	Hs
		508670 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		TRI39_HUMAN (6-492): 2.81e-128: 384: 27.48
+	Mm
		508938 UBB_MOUSE (1-228): 7.8e-97: 286: 100.00		RO52_MOUSE (5-491): 3.38e-128: 382: 35.22
+	Hs
		507312 UBB_HUMAN (1-229): 2.65e-99: 289: 100.00		TRI11_HUMAN (2-491): 1.97e-123: 370: 31.91
+	Hs
		507484 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		TRI27_HUMAN (1-492): 1.3e-121: 367: 29.79
+	Xl
		1274149 Q7SY79_XENLA (1-228): 1.28e-92: 285: 100.00		NF7B_XENLA (8-490): 1.08e-109: 340: 24.19
+	Hs
		508900 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		TRI17_HUMAN (7-492): 6.03e-107: 328: 27.62
+	Hs
		507891 UBC_HUMAN (1-228): 7.54e-92: 285: 100.00		TRI26_HUMAN (1-490): 8.73e-106: 327: 25.73
+	Mm
		509100 UBC_MOUSE (1-181): 8.42e-63: 209: 96.13		RO52_MOUSE (5-491): 3.38e-128: 382: 35.22
+	Hs
		987200 RS27A_HUMAN (153-228): 1.77e-44: 147: 100.00		TRI31_HUMAN (1-269): 5.69e-40: 150: 31.25