HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: TOB1 (P50616)
Protein Tob1 (Transducer of erbB-2 1)
Gene: TOB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	17785442, 18056425, 20595394
Identification Methods	pull down, affinity chromatography technology, isothermal titration calorimetry, nuclear magnetic resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0060213 - positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:1900153 - positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 345
+	Hs
		516512 PABP1_HUMAN (1-636): 0: 582: 100.00		TOB2_HUMAN (1-343): 1.31e-131: 381: 55.38
+	Hs
		516461 PABP1_HUMAN (1-636): 0: 582: 100.00		BTG2_HUMAN (1-115): 1.32e-53: 175: 41.88
+	Hs
		680430 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		TOB1_HUMAN (1-345): 4.62e-165: 465: 100.00