HitPredict

Interactor 1: ADT3 (P12236)
ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed]
Gene: SLC25A6

Interactor 2: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25147182
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0016020 - membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 298 Hs			1 4374
+	Hs
		397430 ADT2_HUMAN (1-297): 8.7e-111: 324: 92.26		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Hs
		125082 ADT2_HUMAN (1-297): 8.7e-111: 324: 92.26		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		397518 ADT2_HUMAN (1-297): 8.7e-111: 324: 92.26		SMUF1_HUMAN (3772-4371): 0: 620: 32.84
+	Hs
		518491 ADT3_HUMAN (1-298): 7.29e-113: 329: 100.00		SMUF2_HUMAN (3771-4371): 0: 611: 33.44
+	Hs
		397513 ADT2_HUMAN (1-297): 8.7e-111: 324: 92.26		SMUF2_HUMAN (3771-4371): 0: 611: 33.44
+	Hs
		518515 ADT3_HUMAN (1-298): 7.29e-113: 329: 100.00		HECW2_HUMAN (3131-4373): 4.71e-161: 547: 20.49
+	Sc
		576006 ADT2_YEAST (8-206): 3.48e-38: 138: 24.12		TOM1_YEAST (3831-4374): 1.99e-157: 554: 43.77