HitPredict

Interactor 1: FCG2A (P12318)
Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32)
Gene: FCGR2A

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	0.60	0.408

Property	Details
Experiments	11453982
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 217
+	Hs
		685214 FCG2C_HUMAN (1-317): 2.11e-73: 230: 85.17		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		590607 CD22_HUMAN (31-309): 1.51e-30: 123: 16.61		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		722901 CD22_MOUSE (28-290): 2.28e-25: 108: 13.25		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		411560 FCG3A_HUMAN (16-255): 1.34e-61: 198: 43.03		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		557622 FCG2C_HUMAN (1-317): 2.11e-73: 230: 85.17		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		412048 FCG2C_HUMAN (1-317): 2.11e-73: 230: 85.17		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		522812 FCG2C_HUMAN (1-317): 2.11e-73: 230: 85.17		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		433545 FCG2A_HUMAN (1-317): 9.47e-67: 213: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Dm
		219802 O44924_DROME (3-306): 2.92e-48: 175: 12.77		ABL_DROME (4-135): 1e-22: 97.4: 37.68
+	Hs
		519400 FCERA_HUMAN (20-247): 4.5e-59: 191: 32.02		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		433569 CD22_HUMAN (31-309): 1.51e-30: 123: 16.61		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Mm
		639452 FCRL5_MOUSE (22-294): 3.17e-27: 113: 15.72		LYN_MOUSE (129-215): 2.66e-11: 64.2: 22.47
+	Hs
		433507 TUTLB_HUMAN (28-309): 3.52e-25: 107: 14.84		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Mm
		435878 FCGR1_MOUSE (7-311): 3.47e-26: 108: 17.28		HCK_MOUSE (119-215): 2.26e-11: 64.2: 23.23
+	Hs
		442771 FCGR1_HUMAN (30-277): 9.95e-25: 104: 16.54		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		434081 TUTLB_HUMAN (28-309): 3.52e-25: 107: 14.84		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		523211 TUTLB_HUMAN (28-309): 3.52e-25: 107: 14.84		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		433742 PTK7_HUMAN (124-313): 1.3e-18: 88.3: 10.68		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		434111 ROBO1_HUMAN (1-115): 1.09e-15: 79.8: 17.46		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		434019 ROBO2_HUMAN (1-115): 1.43e-15: 79.5: 14.96		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47