HitPredict

Interactor 1: SKI (P12755)
Ski oncogene (Proto-oncogene c-Ski)
Gene: SKI

Interactor 2: SKIL (P12757)
Ski-like protein (Ski-related oncogene) (Ski-related protein)
Gene: SKIL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 1.00 0.902

The method score is based on:

Property Details
Experiments 9927733, 33961781, 16959829, 25059663
Identification Methods pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains c-SKI_SMAD_bind~c-SKI_SMAD_bind, Ski_Sno~Ski_Sno
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0005634 - nucleus
and 10 others

more...
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 728
Hs

1 684
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024