HitPredict

Interactor 1: ARAF (P10398)
Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks)
Gene: ARAF

Interactor 2: RRAS2 (P62070)
Ras-related protein R-Ras2 (EC 3.6.5.2) (Ras-like protein TC21) (Teratocarcinoma oncogene)
Gene: RRAS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.80	0.587

Property	Details
Experiments	12620389
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, PK_Tyr_Ser-Thr~Ras, RBD~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 606 Hs			1 204
+	Hs
		520666 ARAF_HUMAN (1-606): 0: 571: 100.00		RRAS_HUMAN (13-204): 2.24e-81: 243: 67.71
+	Hs
		521281 ARAF_HUMAN (1-606): 0: 571: 100.00		RB11A_HUMAN (4-202): 5.07e-78: 234: 25.70
+	Hs
		578441 BRAF_HUMAN (3-604): 0: 537: 54.78		RAB1A_HUMAN (1-202): 7.66e-83: 246: 26.32
+	Hs
		400178 RAF1_HUMAN (12-606): 0: 527: 60.27		RRAS_HUMAN (13-204): 2.24e-81: 243: 67.71
+	Hs
		374357 ARAF_HUMAN (1-606): 0: 571: 100.00		RASH_HUMAN (14-203): 8.9e-57: 179: 55.26
+	Hs
		375113 ARAF_HUMAN (1-606): 0: 571: 100.00		RASK_HUMAN (14-199): 3.16e-54: 172: 54.84
+	Hs
		375839 Q96II5_HUMAN (1-606): 0: 565: 99.51		RASK_HUMAN (14-199): 3.16e-54: 172: 54.84
+	Hs
		165119 BRAF_HUMAN (3-604): 0: 537: 54.78		RASM_HUMAN (27-177): 1.88e-64: 199: 63.82
+	Rn
		569433 ARAF_RAT (1-606): 0: 557: 95.22		RASH_RAT (14-203): 8.9e-57: 179: 55.26
+	Mm
		411153 ARAF_MOUSE (1-606): 0: 554: 94.88		RASH_MOUSE (14-203): 8.9e-57: 179: 55.26
+	Mm
		411149 ARAF_MOUSE (1-606): 0: 554: 94.88		RASK_MOUSE (14-203): 1.77e-54: 173: 54.12
+	Hs
		165118 RAF1_HUMAN (12-606): 0: 527: 60.27		RASM_HUMAN (27-177): 1.88e-64: 199: 63.82
+	Hs
		578435 BRAF_HUMAN (3-604): 0: 537: 54.78		RAP1B_HUMAN (14-193): 4.72e-58: 182: 51.93
+	Hs
		578442 BRAF_HUMAN (3-604): 0: 537: 54.78		RAP1A_HUMAN (14-177): 2.13e-57: 181: 53.94
+	Mm
		700373 BRAF_MOUSE (3-604): 0: 535: 54.53		RAP1B_MOUSE (14-193): 4.72e-58: 182: 51.93
+	Hs
		374377 BRAF_HUMAN (3-604): 0: 537: 54.78		RASH_HUMAN (14-203): 8.9e-57: 179: 55.26
+	Mm
		700351 BRAF_MOUSE (3-604): 0: 535: 54.53		RASH_MOUSE (14-203): 8.9e-57: 179: 55.26
+	Hs
		375142 BRAF_HUMAN (3-604): 0: 537: 54.78		RASK_HUMAN (14-199): 3.16e-54: 172: 54.84
+	Hs
		374327 RAF1_HUMAN (12-606): 0: 527: 60.27		RASH_HUMAN (14-203): 8.9e-57: 179: 55.26
+	Hs
		375069 RAF1_HUMAN (12-606): 0: 527: 60.27		RASK_HUMAN (14-199): 3.16e-54: 172: 54.84