HitPredict

Interactor 1: CADH1 (P12830)
Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]
Gene: CDH1

Interactor 2: PSN1 (P49768)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: PSEN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.712

The method score is based on:

Property	Details
Experiments	19114997, 10635315, 34591612, 16126725, 11953314
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0008013 - beta-catenin binding GO:0010468 - regulation of gene expression GO:0016020 - membrane GO:0030054 - cell junction and 6 others more... GO:0042307 - positive regulation of protein import into nucleus GO:0045296 - cadherin binding GO:0045893 - positive regulation of DNA-templated transcription GO:0098609 - cell-cell adhesion GO:0098794 - postsynapse GO:0098978 - glutamatergic synapse
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	882
Hs

1	467

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024