HitPredict

Interactor 1: BCL2 (P10415)
Apoptosis regulator Bcl-2
Gene: BCL2

Interactor 2: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	17274640
Identification Methods	affinity chromatography technology, antibody array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0005829 - cytosol and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 239 Hs			1 323
+	Mm
		522157 BCL2_MOUSE (1-239): 2.12e-100: 293: 90.38		PP1G_MOUSE (1-323): 0: 602: 99.69
+	Mm
		522156 BCL2_MOUSE (1-239): 2.12e-100: 293: 90.38		PP1A_MOUSE (1-323): 0: 579: 90.36
+	Hs
		522069 BCL2_HUMAN (1-239): 1.24e-93: 276: 100.00		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Hs
		786563 B2CL1_HUMAN (11-239): 2.91e-77: 234: 42.68		PP1G_HUMAN (1-323): 0: 603: 100.00
+	Hs
		522070 BCL2_HUMAN (1-239): 1.24e-93: 276: 100.00		PP1B_HUMAN (1-322): 0: 560: 86.89
+	Mm
		989692 B2CL1_MOUSE (11-239): 2.8e-73: 224: 41.42		PP1G_MOUSE (1-323): 0: 602: 99.69
+	Hs
		967685 B2CL1_HUMAN (11-239): 2.91e-77: 234: 42.68		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Hs
		522074 BCL2_HUMAN (1-239): 1.24e-93: 276: 100.00		PP2AA_HUMAN (8-312): 5.37e-178: 496: 46.08
+	Mm
		989684 BAX_MOUSE (34-231): 2.53e-49: 161: 21.36		PP1G_MOUSE (1-323): 0: 602: 99.69
+	Hs
		967684 BAX_HUMAN (34-231): 2.1e-51: 167: 24.27		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Hs
		967895 B2CL2_HUMAN (50-239): 5.99e-51: 166: 40.31		PP1A_HUMAN (1-323): 0: 579: 90.66