Protein: BAX
Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)

Gene: BAX
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q07812

Gene Ontology (top 5):
GO:0001541 - ovarian follicle development
GO:0001764 - neuron migration
GO:0001777 - T cell homeostatic proliferation
GO:0001782 - B cell homeostasis
GO:0001783 - B cell apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1060079

B2CL1
Bcl-2-like protein 1

33

18

Small-scale

0.994

High

522077

BCL2
Apoptosis regulator Bcl-2

25

17

Small-scale

0.990

High

1060078

BAX
Apoptosis regulator BAX

17

17

Small-scale

0.986

High

1060080

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

13

16

Small-scale

0.980

High

1060113

B2CL2
Bcl-2-like protein 2

8

17

Small-scale

0.968

High

219620

B2L11
Bcl-2-like protein 11

7

17

Small-scale

0.962

High

1060087

BAK
Bcl-2 homologous antagonist/killer

6

17

Small-scale

0.935

High

939615

BID
BH3-interacting domain death agonist

3

10

Small-scale

0.865

High

1060132

B2L10
Bcl-2-like protein 10

3

4

Small-scale

0.847

High

413696

P53
Cellular tumor antigen p53

2

9

Small-scale

0.806

High

1060086

B2LA1
Bcl-2-related protein A1

2

16

Small-scale

0.783

High

241489

PRKN
E3 ubiquitin-protein ligase parkin

2

7

Small-scale

0.754

High

1060115

BAD
Bcl2-associated agonist of cell death

2

8

Small-scale

0.737

High

558068

XRCC6
X-ray repair cross-complementing protein 6

7

2

Small-scale

0.736

High

1060124

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

2

Small-scale

0.724

High

533649

CLUS
Clusterin

5

1

Small-scale

0.702

High

1060131

B2L12
Bcl-2-like protein 12

4

2

Small-scale

0.699

High

1060141

ASC
Apoptosis-associated speck-like protein containing a CARD

1

2

Small-scale

0.696

High

1060143

SHLB1
Endophilin-B1

3

1

Small-scale

0.664

High

640863

VDAC1
Non-selective voltage-gated ion channel VDAC1

3

8

Small-scale

0.646

High

505092

BNIP5
Protein BNIP5

1

2

High-throughput

0.618

High

1060083

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

7

Small-scale

0.618

High

1060136

UVRAG
UV radiation resistance-associated gene protein

2

0

Small-scale

0.595

High

642824

KCNA3
Potassium voltage-gated channel subfamily A member 3

2

1

Small-scale

0.595

High

1060092

B2L15
Bcl-2-like protein 15

2

0

High-throughput

0.585

High

269182

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

1060144

TRI17
E3 ubiquitin-protein ligase TRIM17

1

3

Small-scale

0.578

High

613004

EGR1
Early growth response protein 1

2

0

Small-scale

0.576

High

275887

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

1

Small-scale

0.573

High

384403

CRYAA
Alpha-crystallin A chain

1

6

Small-scale

0.561

High

384658

CRYAB
Alpha-crystallin B chain

1

6

Small-scale

0.561

High

690937

1433T
14-3-3 protein theta

1

4

Small-scale

0.561

High

1060134

OCAD1
OCIA domain-containing protein 1

2

0

High-throughput

0.559

High

1060120

FXL20
F-box/LRR-repeat protein 20

1

0

Small-scale

0.554

High

728192

AKT1
RAC-alpha serine/threonine-protein kinase

2

5

Small-scale

0.552

High

1060103

HUNIN
Humanin

1

0

Small-scale

0.549

High

1038280

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

9

High-throughput

0.541

High

1042852

ERCC6
DNA excision repair protein ERCC-6

1

1

High-throughput

0.536

High

1051209

KPCZ
Protein kinase C zeta type

1

6

Small-scale

0.536

High

1060089

EDRF1
Erythroid differentiation-related factor 1

1

1

High-throughput

0.536

High

1060122

SPB12
Serpin B12

1

2

High-throughput

0.536

High

1060130

WDR76
WD repeat-containing protein 76

1

2

High-throughput

0.536

High

551995

ADT1
ADP/ATP translocase 1

1

0

Small-scale

0.529

High

1060085

IRF3
Interferon regulatory factor 3

1

1

Small-scale

0.527

High

1060111

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

0

High-throughput

0.518

High

1060139

LEF1
Lymphoid enhancer-binding factor 1

1

0

High-throughput

0.518

High

891485

GSK3B
Glycogen synthase kinase-3 beta

1

9

Small-scale

0.516

High

791329

SYUA
Alpha-synuclein

1

1

High-throughput

0.515

High

167083

GEMI2
Gem-associated protein 2

1

0

High-throughput

0.513

High

326252

PRS23
Serine protease 23

1

0

High-throughput

0.513

High

675476

TYY1
Transcriptional repressor protein YY1

1

0

High-throughput

0.513

High

892552

DNLI3
DNA ligase 3

1

0

High-throughput

0.513

High

1060090

PPM1J
Protein phosphatase 1J

1

0

High-throughput

0.513

High

1060104

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1060105

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

0

High-throughput

0.513

High

1060125

ATAD5
ATPase family AAA domain-containing protein 5

1

0

High-throughput

0.513

High

1060127

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

1060142

NSF1C
NSFL1 cofactor p47

1

0

High-throughput

0.513

High

1060100

R144B
E3 ubiquitin-protein ligase RNF144B

1

0

Small-scale

0.512

High

282578

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

2

Small-scale

0.501

High

1060126

PARK7
Parkinson disease protein 7

1

1

Small-scale

0.501

High

64431

BDP1
Transcription factor TFIIIB component B'' homolog

1

1

High-throughput

0.489

High

1060106

NIN
Ninein

1

1

High-throughput

0.489

High

729774

1433B
14-3-3 protein beta/alpha

1

4

Small-scale

0.481

High

208829

ZBT24
Zinc finger and BTB domain-containing protein 24

1

0

Small-scale

0.480

High

347662

BAG3
BAG family molecular chaperone regulator 3

1

5

High-throughput

0.479

High

354326

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

8

Small-scale

0.479

High

397737

NU5M
NADH-ubiquinone oxidoreductase chain 5

1

1

Small-scale

0.479

High

532538

CH60
60 kDa heat shock protein, mitochondrial

1

7

Small-scale

0.479

High

559320

XRCC5
X-ray repair cross-complementing protein 5

1

2

Small-scale

0.479

High

610310

PRS6A
26S proteasome regulatory subunit 6A

1

2

Small-scale

0.479

High

730537

1433S
14-3-3 protein sigma

1

4

Small-scale

0.479

High

761649

HSP74
Heat shock 70 kDa protein 4

1

2

Small-scale

0.479

High

853660

MK08
Mitogen-activated protein kinase 8

1

13

Small-scale

0.479

High

862067

YAP1
Transcriptional coactivator YAP1

1

4

Small-scale

0.479

High

967684

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

11

High-throughput

0.479

High

970392

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

1004481

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1022700

XIAP
E3 ubiquitin-protein ligase XIAP

1

1

Small-scale

0.479

High

1034986

KPCE
Protein kinase C epsilon type

1

1

Small-scale

0.479

High

1060081

EP300
Histone acetyltransferase p300

1

5

Small-scale

0.479

High

1060084

TRI14
Tripartite motif-containing protein 14

1

4

High-throughput

0.479

High

1060091

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

Small-scale

0.479

High

1060093

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1060096

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

1060097

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

3

Small-scale

0.479

High

1060099

BOP
Protein Bop

1

6

Small-scale

0.479

High

1060107

ARL10
ADP-ribosylation factor-like protein 10

1

1

High-throughput

0.479

High

1060112

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1060118

MOAP1
Modulator of apoptosis 1

1

2

Small-scale

0.479

High

1060121

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

3

Small-scale

0.479

High

1060123

BBC3B
Bcl-2-binding component 3, isoforms 3/4

1

5

Small-scale

0.479

High

1060128

EPAS1
Endothelial PAS domain-containing protein 1

1

5

Small-scale

0.479

High

1060137

HDAC6
Protein deacetylase HDAC6

1

1

Small-scale

0.479

High

1060138

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

275009

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

418086

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

541447

FGFR1
Fibroblast growth factor receptor 1

1

0

Small-scale

0.458

High

695290

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

934519

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

968893

PRS8
26S proteasome regulatory subunit 8

1

0

Small-scale

0.458

High

1060082

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1060095

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1060098

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1060109

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1060110

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1060114

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

1060116

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.458

High

1060129

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

1060133

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

Small-scale

0.458

High

1060135

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1060140

APC4
Anaphase-promoting complex subunit 4

1

0

Small-scale

0.458

High

1060102

VRK2
Serine/threonine-protein kinase VRK2

1

3

Small-scale

0.445

High

1060145

MTCH2
Mitochondrial carrier homolog 2

1

4

High-throughput

0.445

High

1060119

GIMA5
GTPase IMAP family member 5

1

5

Small-scale

0.437

High

841166

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.426

High

1060094

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

1060101

UN93A
Protein unc-93 homolog A

1

0

High-throughput

0.426

High

1060108

CTL1
Choline transporter-like protein 1

1

0

High-throughput

0.426

High

1060088

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

768030

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1060117

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025