Interactor 1: ODP2 (P10515)
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)
Gene: DLAT

Interactor 2: ODP2 (P10515)
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)
Gene: DLAT

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.51 1.00 0.715

The method score is based on:

Property Details
Experiments 18184587, 18184588
Identification Methods 3D electron microscopy
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains 2-oxoacid_dh~2-oxoacid_dh, 2-oxoacid_dh~Biotin_lipoyl, Biotin_lipoyl~Biotin_lipoyl, E3_binding~E3_binding
Common GO terms GO:0004742 - dihydrolipoyllysine-residue acetyltransferase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006006 - glucose metabolic process
GO:0006086 - pyruvate decarboxylation to acetyl-CoA
and 3 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 647
Hs

1 647
+ Mm
+ Hs
+ Hs
+ At
+ At
+ At
+ Ce
+ Mm
+ Sc
+ Mm
+ Sc
+ At
+ Ss
+ Zm

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Last updated: 11Aug2025