HitPredict

Interactor 1: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Interactor 2: RECQ1 (P46063)
ATP-dependent DNA helicase Q1 (EC 5.6.2.4) (DNA 3'-5' helicase Q1) (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1)
Gene: RECQL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	23396353
Identification Methods	tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003678 - DNA helicase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane and 1 others more... GO:0016887 - ATP hydrolysis activity
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 609 Hs			1 649
+	Hs
		523746 XRCC6_HUMAN (1-609): 0: 666: 100.00		WRN_HUMAN (11-642): 8.49e-137: 436: 26.10
+	Hs
		294316 XRCC6_HUMAN (1-609): 0: 666: 100.00		RECQ4_HUMAN (76-453): 5.17e-127: 405: 30.39
+	Hs
		523624 XRCC6_HUMAN (1-609): 0: 666: 100.00		BLM_HUMAN (48-617): 4.7e-125: 404: 35.01
+	Hs
		523915 XRCC6_HUMAN (1-609): 0: 666: 100.00		DDX17_HUMAN (8-505): 7.91e-129: 398: 14.54
+	Hs
		523506 XRCC6_HUMAN (1-609): 0: 666: 100.00		DDX5_HUMAN (9-468): 1.14e-125: 386: 15.97
+	Hs
		523861 XRCC6_HUMAN (1-609): 0: 666: 100.00		DDX42_HUMAN (2-458): 4.83e-115: 368: 14.44
+	Hs
		133861 XRCC6_HUMAN (1-609): 0: 666: 100.00		DDX3X_HUMAN (16-447): 1.24e-115: 362: 12.66
+	Hs
		524828 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		RECQ1_HUMAN (1-649): 1.14e-156: 467: 100.00
+	Hs
		524923 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		WRN_HUMAN (11-642): 8.49e-137: 436: 26.10
+	Hs
		294317 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		RECQ4_HUMAN (76-453): 5.17e-127: 405: 30.39
+	Hs
		525006 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		DDX17_HUMAN (8-505): 7.91e-129: 398: 14.54