HitPredict

Interactor 1: CCL4 (P13236)
C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]
Gene: CCL4

Interactor 2: GP152 (Q8TDT2)
Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5)
Gene: GPR152

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 92 Hs			1 470
+	Hs
		1246071 CC4L_HUMAN (1-92): 6.45e-34: 113: 96.74		GP152_HUMAN (1-470): 1.24e-90: 285: 100.00
+	Hs
		1305163 CCL13_HUMAN (1-91): 7.29e-37: 121: 39.56		ACKR4_HUMAN (18-342): 7.22e-88: 274: 23.21
+	Hs
		945622 CCL8_HUMAN (1-91): 2.63e-31: 107: 38.04		ACKR4_HUMAN (18-342): 7.22e-88: 274: 23.21
+	Hs
		526565 CCL4_HUMAN (1-92): 8.21e-38: 123: 100.00		CCR5_HUMAN (1-339): 1.1e-74: 240: 18.16
+	Hs
		561733 CL3L1_HUMAN (1-92): 5.95e-38: 123: 58.70		CCR5_HUMAN (1-339): 1.1e-74: 240: 18.16
+	Hs
		849654 CCL13_HUMAN (1-91): 7.29e-37: 121: 39.56		CCR5_HUMAN (1-339): 1.1e-74: 240: 18.16
+	Hs
		486239 CCL3_HUMAN (1-92): 6.04e-35: 116: 57.61		CCR5_HUMAN (1-339): 1.1e-74: 240: 18.16
+	Hs
		783833 CCL13_HUMAN (1-91): 7.29e-37: 121: 39.56		CCR2_HUMAN (31-320): 1.47e-71: 233: 21.62
+	Hs
		526560 CCL4_HUMAN (1-92): 8.21e-38: 123: 100.00		CCR1_HUMAN (31-337): 2.51e-70: 229: 19.26
+	Hs
		561728 CL3L1_HUMAN (1-92): 5.95e-38: 123: 58.70		CCR1_HUMAN (31-337): 2.51e-70: 229: 19.26
+	Hs
		849647 CCL8_HUMAN (1-91): 2.63e-31: 107: 38.04		CCR5_HUMAN (1-339): 1.1e-74: 240: 18.16
+	Hs
		686667 CCL14_HUMAN (1-92): 2.01e-35: 117: 43.01		CCR1_HUMAN (31-337): 2.51e-70: 229: 19.26
+	Hs
		486230 CCL3_HUMAN (1-92): 6.04e-35: 116: 57.61		CCR1_HUMAN (31-337): 2.51e-70: 229: 19.26
+	Mm
		486358 CCL2_MOUSE (1-92): 6.78e-34: 115: 39.79		CCR2_MOUSE (5-341): 2.59e-70: 229: 17.15
+	Mm
		500591 CCL3_MOUSE (1-92): 5.78e-37: 121: 60.87		CCR3_MOUSE (29-312): 6.01e-68: 223: 17.69
+	Hs
		486238 CCL3_HUMAN (1-92): 6.04e-35: 116: 57.61		CCR4_HUMAN (2-336): 9.18e-69: 225: 15.69
+	Hs
		783815 CCL8_HUMAN (1-91): 2.63e-31: 107: 38.04		CCR2_HUMAN (31-320): 1.47e-71: 233: 21.62
+	Hs
		686635 CCL8_HUMAN (1-91): 2.63e-31: 107: 38.04		CCR1_HUMAN (31-337): 2.51e-70: 229: 19.26
+	Mm
		534669 CCL4_MOUSE (1-92): 2.15e-32: 109: 76.09		CCR3_MOUSE (29-312): 6.01e-68: 223: 17.69
+	Mm
		534670 CCL4_MOUSE (1-92): 2.15e-32: 109: 76.09		CCR5_MOUSE (31-340): 2.27e-68: 223: 17.68