Protein: MCR1
NADH-cytochrome b5 reductase 2 (EC 1.6.2.2) (Mitochondrial cytochrome b reductase) (p34/p32) [Cleaved into: NADH-cytochrome b5 reductase p34 form; NADH-cytochrome b5 reductase p32 form]

Gene: MCR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 79
UniProt ID: P36060

Gene Ontology (top 5):
GO:0003954 - NADH dehydrogenase activity
GO:0004128 - cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005758 - mitochondrial intermembrane space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

526393

HSP72
Heat shock protein SSA2

2

10

Small-scale

0.619

High

780493

RSP5
E3 ubiquitin-protein ligase RSP5

2

3

Small-scale

0.602

High

579199

HSC82
ATP-dependent molecular chaperone HSC82

2

11

Small-scale

0.584

High

780503

TOM22
Mitochondrial import receptor subunit TOM22

2

1

High-throughput

0.584

High

670573

SIS1
Protein SIS1

2

7

Small-scale

0.570

High

523600

HSP71
Heat shock protein SSA1

2

10

Small-scale

0.565

High

780507

ALO
D-arabinono-1,4-lactone oxidase

1

1

High-throughput

0.541

High

544455

SSB1
Ribosome-associated molecular chaperone SSB1

2

9

Small-scale

0.521

High

780495

SSB2
Ribosome-associated molecular chaperone SSB2

2

9

Small-scale

0.521

High

392551

HSP82
ATP-dependent molecular chaperone HSP82

1

11

Small-scale

0.512

High

585611

STI1
Heat shock protein STI1

1

7

Small-scale

0.512

High

675905

MAS5
Mitochondrial protein import protein MAS5

1

5

Small-scale

0.512

High

726932

HS104
Heat shock protein 104

1

6

Small-scale

0.512

High

780497

DJP1
DnaJ-like protein 1

1

6

Small-scale

0.501

High

780508

CDC14
Tyrosine-protein phosphatase CDC14

1

3

High-throughput

0.489

High

668899

ERG6
Sterol 24-C-methyltransferase ERG6

1

2

High-throughput

0.481

High

357701

CYC1
Cytochrome c isoform 1

1

1

High-throughput

0.479

High

452011

TOM70
Mitochondrial import receptor subunit TOM70

1

5

High-throughput

0.479

High

510383

HSP77
Import motor subunit, mitochondrial

1

8

High-throughput

0.479

High

626688

HSP60
Heat shock protein 60, mitochondrial

1

7

Small-scale

0.479

High

739339

ZUO1
Zuotin

1

5

Small-scale

0.479

High

746791

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

1

High-throughput

0.479

High

752122

HSP78
Heat shock protein 78, mitochondrial

1

6

High-throughput

0.479

High

780483

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.479

High

780489

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

8

Small-scale

0.479

High

780491

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

1

High-throughput

0.479

High

780496

SNL1
HSP70 co-chaperone SNL1

1

2

Small-scale

0.479

High

780504

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

780509

COX12
Cytochrome c oxidase subunit 12, mitochondrial

1

1

High-throughput

0.479

High

780516

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.479

High

780517

SCC1
Sister chromatid cohesion protein 1

1

1

Small-scale

0.479

High

780520

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

1

High-throughput

0.479

High

780521

MIC10
MICOS complex subunit MIC10

1

1

Small-scale

0.479

High

780513

PIN3
[PSI+] inducibility protein 3

1

1

High-throughput

0.464

High

357766

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.458

High

382877

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

399817

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

0

High-throughput

0.458

High

453134

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

Small-scale

0.458

High

597679

OM45
Mitochondrial outer membrane protein OM45

1

0

High-throughput

0.458

High

602005

CBF1
Centromere-binding protein 1

1

0

High-throughput

0.458

High

641091

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.458

High

780485

RM17
Large ribosomal subunit protein mL46

1

0

High-throughput

0.458

High

780490

OM14
Mitochondrial outer membrane protein OM14

1

0

High-throughput

0.458

High

780494

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

780498

ERG10
Acetyl-CoA acetyltransferase

1

0

High-throughput

0.458

High

780506

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

780511

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

602404

PHO85
Cyclin-dependent protein kinase PHO85

1

4

High-throughput

0.457

High

366999

ATPB
ATP synthase subunit beta, mitochondrial

1

3

High-throughput

0.445

High

453541

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.445

High

755076

GCN1
eIF-2-alpha kinase activator GCN1

1

2

High-throughput

0.445

High

780484

PET10
Protein PET10

1

1

High-throughput

0.439

High

645717

HSP74
Heat shock protein SSA4

1

10

Small-scale

0.437

High

706778

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

741343

HSP7F
Heat shock protein homolog SSE1

1

16

Small-scale

0.437

High

779531

LHS1
Heat shock protein 70 homolog LHS1

1

11

Small-scale

0.437

High

780487

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

780488

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.437

High

780492

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

780500

VTC2
Vacuolar transporter chaperone complex subunit 2

1

1

Small-scale

0.437

High

780501

VTC4
Vacuolar transporter chaperone complex subunit 4

1

1

Small-scale

0.437

High

780502

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

780510

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.437

High

394444

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

365017

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.407

High

486132

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.407

High

592173

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.407

High

780499

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

780519

AHA1
Hsp90 co-chaperone AHA1

1

0

Small-scale

0.292

High

750226

PRP40
Pre-mRNA-processing protein PRP40

1

0

High-throughput

0.261

Low

780518

HSP42
Heat shock protein 42

1

0

Small-scale

0.261

Low

705158

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

743833

IES6
Chromatin-remodeling complex subunit IES6

1

0

High-throughput

0.249

Low

780482

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

780512

SEC10
Exocyst complex component SEC10

1

0

Small-scale

0.249

Low

780514

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.249

Low

780515

FEX1
Fluoride export protein 1

1

0

High-throughput

0.249

Low

780486

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.238

Low

780505

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025