Protein: MRC1
Mediator of replication checkpoint protein 1 (DNA replication checkpoint mediator MRC1)

Gene: MRC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 66
UniProt ID: P25588

Gene Ontology (top 5):
GO:0000076 - DNA replication checkpoint signaling
GO:0000723 - telomere maintenance
GO:0000781 - chromosome, telomeric region
GO:0005634 - nucleus
GO:0006260 - DNA replication

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

634863

MCM4
DNA replication licensing factor MCM4

7

4

Small-scale

0.740

High

622141

MCM3
DNA replication licensing factor MCM3

5

3

Small-scale

0.709

High

634900

CSM3
Chromosome segregation in meiosis protein 3

6

0

Small-scale

0.698

High

634861

MCM2
DNA replication licensing factor MCM2

4

3

Small-scale

0.686

High

634889

TOF1
Topoisomerase 1-associated factor 1

5

0

Small-scale

0.685

High

634907

DIA2
Protein DIA2

4

0

Small-scale

0.681

High

634905

CDC45
Cell division control protein 45

5

0

Small-scale

0.676

High

634896

SLD5
DNA replication complex GINS protein SLD5

5

0

Small-scale

0.672

High

605920

RAD53
Serine/threonine-protein kinase RAD53

4

0

Small-scale

0.651

High

634865

HOG1
Mitogen-activated protein kinase HOG1

2

0

Small-scale

0.631

High

622860

DPB2
DNA polymerase epsilon subunit B

3

0

Small-scale

0.625

High

602314

DPOE
DNA polymerase epsilon catalytic subunit A

2

0

Small-scale

0.605

High

634888

MCM6
DNA replication licensing factor MCM6

2

3

Small-scale

0.584

High

634862

MCM5
Minichromosome maintenance protein 5

2

3

Small-scale

0.571

High

634869

SMC1
Structural maintenance of chromosomes protein 1

1

1

Small-scale

0.561

High

634886

SMC3
Structural maintenance of chromosomes protein 3

1

1

Small-scale

0.561

High

634894

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

1

Small-scale

0.561

High

634866

SPT16
FACT complex subunit SPT16

2

0

Small-scale

0.559

High

634893

SEN1
Helicase SEN1

2

0

Small-scale

0.559

High

634890

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

2

0

High-throughput

0.551

High

510415

SSB1
Ribosome-associated molecular chaperone SSB1

2

0

High-throughput

0.547

High

634895

CTF4
DNA polymerase alpha-binding protein

2

0

Small-scale

0.547

High

419814

SNF1
Carbon catabolite-derepressing protein kinase

1

0

Small-scale

0.537

High

634864

PSK1
Serine/threonine-protein kinase PSK1

1

0

Small-scale

0.537

High

634883

SCC3
Cohesin subunit SCC3

1

0

Small-scale

0.537

High

634872

SPT7
Transcriptional activator SPT7

1

0

High-throughput

0.513

High

634901

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.513

High

565474

PHO85
Cyclin-dependent protein kinase PHO85

1

1

Small-scale

0.501

High

586461

PRP9
Pre-mRNA-splicing factor PRP9

1

0

High-throughput

0.486

High

608736

CHL1
ATP-dependent DNA helicase CHL1

1

0

Small-scale

0.480

High

634875

ATR
Serine/threonine-protein kinase MEC1

1

0

Small-scale

0.480

High

634897

STE20
Serine/threonine-protein kinase STE20

1

0

Small-scale

0.480

High

634908

SCC1
Sister chromatid cohesion protein 1

1

0

Small-scale

0.480

High

339468

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

634874

CENPA
Histone H3-like centromeric protein CSE4

1

1

High-throughput

0.479

High

634876

MCM7
DNA replication licensing factor MCM7

1

1

Small-scale

0.479

High

634892

H3
Histone H3

1

1

High-throughput

0.479

High

634870

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

388085

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

557909

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

584667

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.458

High

634860

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

634868

RAD24
Checkpoint protein RAD24

1

0

Small-scale

0.458

High

634873

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

634877

RT107
Regulator of Ty1 transposition protein 107

1

0

Small-scale

0.458

High

634879

SAW1
Single-strand annealing weakened protein 1

1

0

Small-scale

0.458

High

634880

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.458

High

634882

PSF2
DNA replication complex GINS protein PSF2

1

0

Small-scale

0.458

High

634891

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

634898

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

634899

LRS4
Monopolin complex subunit LRS4

1

0

High-throughput

0.458

High

634902

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

634906

SGO1
Shugoshin

1

0

High-throughput

0.458

High

634867

HSP7F
Heat shock protein homolog SSE1

1

1

High-throughput

0.445

High

493315

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

634878

SPT8
Transcription factor SPT8

1

0

High-throughput

0.426

High

634887

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.426

High

634885

GWT1
GPI-anchored wall transfer protein 1

1

0

High-throughput

0.279

Low

634881

RPN3
26S proteasome regulatory subunit RPN3

1

0

High-throughput

0.269

Low

608764

KCC2
Calcium/calmodulin-dependent protein kinase II

1

0

High-throughput

0.261

Low

634884

STB2
Protein STB2

1

0

High-throughput

0.251

Low

525691

ATR1
Aminotriazole resistance protein

1

0

High-throughput

0.249

Low

634904

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

634871

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

634903

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low

634909

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024