HitPredict

Interactor 1: CCL2 (P13500)
C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2)
Gene: CCL2

Interactor 2: CCR5 (P51681)
C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)
Gene: CCR5

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	10477718
Identification Methods	biochemical, competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0007166 - cell surface receptor signaling pathway GO:0007186 - G protein-coupled receptor signaling pathway GO:0071222 - cellular response to lipopolysaccharide
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 99 Hs			1 352
+	Hs
		849654 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00
+	Mm
		486358 CCL2_MOUSE (1-94): 1.45e-35: 119: 54.26		CCR2_MOUSE (9-352): 3.95e-85: 263: 74.71
+	Hs
		1305163 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35
+	Hs
		561733 CL3L1_HUMAN (1-94): 2.21e-35: 117: 38.30		CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00
+	Hs
		526565 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00
+	Hs
		783833 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CCR2_HUMAN (2-331): 3.91e-79: 248: 70.91
+	Hs
		561728 CL3L1_HUMAN (1-94): 2.21e-35: 117: 38.30		CCR1_HUMAN (12-352): 6.79e-81: 252: 56.73
+	Hs
		526560 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CCR1_HUMAN (12-352): 6.79e-81: 252: 56.73
+	Mm
		500591 CCL3_MOUSE (1-94): 1.78e-34: 115: 37.23		CCR3_MOUSE (6-352): 1.47e-80: 251: 55.46
+	Mm
		500590 CCL3_MOUSE (1-94): 1.78e-34: 115: 37.23		CCR1_MOUSE (4-352): 2.53e-73: 232: 54.57
+	Hs
		849619 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CCR3_HUMAN (1-352): 2.82e-68: 219: 49.86
+	Hs
		526561 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CXCR5_HUMAN (7-346): 8.85e-70: 224: 26.74
+	Hs
		561732 CL3L1_HUMAN (1-94): 2.21e-35: 117: 38.30		CCR3_HUMAN (1-352): 2.82e-68: 219: 49.86
+	Hs
		526564 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CCR3_HUMAN (1-352): 2.82e-68: 219: 49.86
+	Hs
		134400 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		ACKR2_HUMAN (20-312): 2.55e-52: 179: 37.97
+	Mm
		192790 CCL2_MOUSE (1-94): 1.45e-35: 119: 54.26		CCRL2_MOUSE (40-314): 1.49e-52: 179: 37.86
+	Mm
		139696 CCL2_MOUSE (1-94): 1.45e-35: 119: 54.26		ACKR2_MOUSE (6-312): 1.28e-51: 177: 36.22
+	Hs
		134356 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		ACKR2_HUMAN (20-312): 2.55e-52: 179: 37.97
+	Hs
		134373 CCL8_HUMAN (1-98): 1.39e-33: 113: 69.39		ACKR2_HUMAN (20-312): 2.55e-52: 179: 37.97
+	Hs
		830629 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CXCR3_HUMAN (16-308): 2.75e-47: 165: 36.49