HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	26618866, 31324722
Identification Methods	affinity chromatography technology, cross-linking study, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0034976 - response to endoplasmic reticulum stress
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 414
+	Hs
		161949 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		529208 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PAP1L_HUMAN (96-274): 7.74e-38: 146: 17.74
+	Hs
		528634 CFTR_HUMAN (1-1480): 0: 1031: 100.00		TIA1_HUMAN (99-413): 2.4e-38: 144: 13.76
+	Hs
		529069 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		516343 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		529709 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PABP3_HUMAN (2-382): 7.84e-31: 126: 16.41
+	Hs
		529094 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		162102 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Sc
		376791 YCFI_YEAST (748-1433): 4.8e-56: 216: 14.59		PABP_YEAST (86-269): 2.74e-34: 136: 21.88