Protein: RAB5B
Ras-related protein Rab-5B (EC 3.6.5.2)

Gene: RAB5B
Organism: Homo sapiens
Interactions: 117
UniProt ID: P61020

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0003925 - G protein activity
GO:0005525 - GTP binding
GO:0005768 - endosome
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

956583

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

4

9

Small-scale

0.890

High

724459

GDIA
Rab GDP dissociation inhibitor alpha

4

20

High-throughput

0.813

High

580755

PVR
Poliovirus receptor

2

12

High-throughput

0.811

High

631149

RAB5A
Ras-related protein Rab-5A

1

17

High-throughput

0.691

High

664856

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

20

High-throughput

0.691

High

894523

GDIB
Rab GDP dissociation inhibitor beta

1

20

High-throughput

0.691

High

956594

FNDC5
Fibronectin type III domain-containing protein 5

1

7

High-throughput

0.691

High

956597

RAB2B
Ras-related protein Rab-2B

1

19

High-throughput

0.691

High

956618

PKHJ1
Pleckstrin homology domain-containing family J member 1

1

14

High-throughput

0.691

High

956595

RIN3
Ras and Rab interactor 3

1

20

Small-scale

0.680

High

956598

RIN2
Ras and Rab interactor 2

1

20

Small-scale

0.680

High

839141

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

15

Small-scale

0.647

High

943565

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

9

High-throughput

0.625

High

901162

RAB7A
Ras-related protein Rab-7a

1

18

Small-scale

0.621

High

956573

RIN1
Ras and Rab interactor 1

1

20

Small-scale

0.621

High

956601

SGSM3
Small G protein signaling modulator 3

1

17

Small-scale

0.621

High

956578

EEA1
Early endosome antigen 1

2

9

Small-scale

0.620

High

956572

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

9

High-throughput

0.618

High

342812

HERC2
E3 ubiquitin-protein ligase HERC2

1

4

Small-scale

0.618

High

400578

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

16

High-throughput

0.618

High

466182

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

900750

RAB5C
Ras-related protein Rab-5C

1

18

High-throughput

0.618

High

955008

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

956566

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

956567

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

956611

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

956619

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.618

High

956621

NUFP1
FMR1-interacting protein NUFIP1

3

1

High-throughput

0.609

High

956593

FHI1B
FHF complex subunit HOOK-interacting protein 1B

1

5

High-throughput

0.589

High

956571

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

15

High-throughput

0.575

High

846056

GLP1R
Glucagon-like peptide 1 receptor

1

2

Small-scale

0.561

High

956596

TBC15
TBC1 domain family member 15

1

20

Small-scale

0.555

High

956612

TBC17
TBC1 domain family member 17

1

20

Small-scale

0.555

High

956587

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.553

High

132585

UPK1A
Uroplakin-1a

1

1

High-throughput

0.536

High

165927

FFAR1
Free fatty acid receptor 1

1

5

High-throughput

0.536

High

178755

SCAM1
Secretory carrier-associated membrane protein 1

1

19

High-throughput

0.536

High

178927

SCAM2
Secretory carrier-associated membrane protein 2

1

19

High-throughput

0.536

High

376602

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

1

High-throughput

0.536

High

563518

CFTR
Cystic fibrosis transmembrane conductance regulator

1

11

High-throughput

0.536

High

602770

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

611814

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.536

High

733321

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.536

High

943031

STX17
Syntaxin-17

1

2

High-throughput

0.536

High

956606

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

4

High-throughput

0.536

High

956609

TX101
Testis-expressed protein 101

1

6

High-throughput

0.536

High

830454

CCNF
Cyclin-F

2

2

High-throughput

0.533

High

956620

SUN2
SUN domain-containing protein 2

2

4

High-throughput

0.526

High

843441

HD
Huntingtin

1

8

High-throughput

0.515

High

325311

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.513

High

956623

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.513

High

956627

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.513

High

956569

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

4

High-throughput

0.489

High

956582

CR021
UPF0711 protein C18orf21

1

1

High-throughput

0.489

High

956599

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

956614

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.489

High

956617

CENPM
Centromere protein M

1

2

High-throughput

0.489

High

956625

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.489

High

956628

WIF1
Wnt inhibitory factor 1

1

3

High-throughput

0.489

High

791238

SYUA
Alpha-synuclein

1

7

High-throughput

0.481

High

956586

APOA5
Apolipoprotein A-V

1

4

High-throughput

0.481

High

956622

PRAF1
Prenylated Rab acceptor protein 1

1

20

High-throughput

0.481

High

189491

STX7
Syntaxin-7

1

16

High-throughput

0.479

High

418046

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

5

High-throughput

0.479

High

507753

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

High-throughput

0.479

High

534860

BIP
Endoplasmic reticulum chaperone BiP

1

7

High-throughput

0.479

High

536867

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

856622

BAG6
Large proline-rich protein BAG6

1

10

Small-scale

0.479

High

947098

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

2

High-throughput

0.479

High

956579

VAMP3
Vesicle-associated membrane protein 3

1

20

High-throughput

0.479

High

956585

FTM
Protein fantom

1

14

High-throughput

0.479

High

956589

CNTRL
Centriolin

1

11

High-throughput

0.479

High

956592

TM192
Transmembrane protein 192

1

1

High-throughput

0.479

High

956603

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

219435

S26A4
Pendrin

1

3

High-throughput

0.445

High

254917

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.445

High

417359

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

7

High-throughput

0.445

High

529473

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.445

High

663629

SC6A2
Sodium-dependent noradrenaline transporter

1

16

High-throughput

0.445

High

870220

S6A12
Sodium- and chloride-dependent betaine transporter

1

16

High-throughput

0.445

High

956574

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

5

High-throughput

0.445

High

956576

MFS10
Major facilitator superfamily domain-containing protein 10

1

6

High-throughput

0.445

High

956588

S46A3
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3

1

9

High-throughput

0.445

High

956604

MF14A
Hippocampus abundant transcript 1 protein

1

11

High-throughput

0.445

High

956608

S12A9
Solute carrier family 12 member 9

1

20

High-throughput

0.445

High

956610

S19A3
Thiamine transporter 2

1

3

High-throughput

0.445

High

956613

SO1B3
Solute carrier organic anion transporter family member 1B3

1

4

High-throughput

0.445

High

956616

S6A13
Sodium- and chloride-dependent GABA transporter 2

1

16

High-throughput

0.445

High

956570

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.439

High

105676

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

176174

PER2
Period circadian protein homolog 2

1

1

Small-scale

0.437

High

285166

EED
Polycomb protein EED

1

11

High-throughput

0.437

High

353176

AGR2
Anterior gradient protein 2 homolog

1

7

High-throughput

0.437

High

371616

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.437

High

588356

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.437

High

695087

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.437

High

767845

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

956568

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.437

High

956575

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

9

High-throughput

0.437

High

956577

CUL7
Cullin-7

1

6

High-throughput

0.437

High

956580

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.437

High

956581

DUS6
Dual specificity protein phosphatase 6

1

7

High-throughput

0.437

High

956584

MYSM1
Deubiquitinase MYSM1

1

3

High-throughput

0.437

High

956590

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

956591

CEP97
Centrosomal protein of 97 kDa

1

12

High-throughput

0.437

High

956600

OPTN
Optineurin

1

20

High-throughput

0.437

High

956602

NEUL4
Neuralized-like protein 4

1

1

Small-scale

0.437

High

956607

DUS9
Dual specificity protein phosphatase 9

1

7

High-throughput

0.437

High

505150

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

3

High-throughput

0.407

High

653230

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

956624

PPM1H
Protein phosphatase 1H

1

6

Small-scale

0.407

High

956626

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.328

High

342533

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

956605

CC85A
Coiled-coil domain-containing protein 85A

1

0

High-throughput

0.279

Low

956615

DPOE3
DNA polymerase epsilon subunit 3

1

0

High-throughput

0.279

Low

904270

BRCA2
Breast cancer type 2 susceptibility protein

1

0

High-throughput

0.249

Low

598716

ANFB
Natriuretic peptides B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025