HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: TRI25 (Q14258)
E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)
Gene: TRIM25

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	31324722
Identification Methods	cross-linking study
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 630
+	Hs
		529198 CFTR_HUMAN (1-1480): 0: 1031: 100.00		TR16L_HUMAN (243-626): 1.7e-93: 293: 22.17
+	Hs
		311845 CFTR_HUMAN (1-1480): 0: 1031: 100.00		TRI16_HUMAN (84-626): 8.02e-84: 275: 22.69
+	Hs
		529591 CFTR_HUMAN (1-1480): 0: 1031: 100.00		ERMAP_HUMAN (280-628): 1.39e-70: 237: 19.05
+	Hs
		529096 CFTR_HUMAN (1-1480): 0: 1031: 100.00		TRI29_HUMAN (84-348): 1.63e-61: 216: 28.67
+	Hs
		529691 CFTR_HUMAN (1-1480): 0: 1031: 100.00		TRIM5_HUMAN (2-281): 6.42e-32: 131: 15.19
+	Hs
		528467 CFTR_HUMAN (1-1480): 0: 1031: 100.00		TRI27_HUMAN (2-358): 2.11e-31: 130: 14.40
+	Hs
		528519 CFTR_HUMAN (1-1480): 0: 1031: 100.00		RO52_HUMAN (72-325): 5.42e-14: 76.6: 13.36
+	Hs
		706716 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		179366 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73