HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12888622
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005874 - microtubule GO:0005886 - plasma membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 404
+	Hs
		529275 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		CASP2_HUMAN (32-404): 3.12e-117: 350: 24.57
+	Hs
		529274 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		CASP3_HUMAN (119-401): 3.41e-96: 290: 25.00
+	Hs
		529432 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		CASP7_HUMAN (102-400): 4.43e-95: 288: 20.19
+	Hs
		529433 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		CASP6_HUMAN (128-402): 4.18e-95: 288: 23.53
+	Hs
		529808 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		CASP8_HUMAN (111-399): 5.88e-84: 266: 20.33
+	Hs
		529192 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		CASPE_HUMAN (145-400): 8.17e-62: 201: 24.24
+	Hs
		840059 MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48		CASP3_HUMAN (119-401): 3.41e-96: 290: 25.00