Protein: CASP7
Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]

Gene: CASP7
Organism: Homo sapiens
Interactions: 70
UniProt ID: P55210

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0003723 - RNA binding
GO:0004190 - aspartic-type endopeptidase activity
GO:0004197 - cysteine-type endopeptidase activity
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

936904

XIAP
E3 ubiquitin-protein ligase XIAP

18

20

Small-scale

0.989

High

936910

BIRC2
Baculoviral IAP repeat-containing protein 2

6

20

Small-scale

0.949

High

936930

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

4

20

Small-scale

0.906

High

936909

BIRC3
Baculoviral IAP repeat-containing protein 3

3

20

Small-scale

0.834

High

188658

BIRC5
Baculoviral IAP repeat-containing protein 5

2

20

Small-scale

0.799

High

936898

CASP9
Caspase-9

2

19

Small-scale

0.799

High

936913

CASP8
Caspase-8

2

19

Small-scale

0.778

High

936897

CASP7
Caspase-7

2

19

Small-scale

0.768

High

518738

GRAB
Granzyme B

4

12

Small-scale

0.678

High

487138

PARP1
Poly [ADP-ribose] polymerase 1

3

9

Small-scale

0.667

High

936899

CASP6
Caspase-6

1

19

Small-scale

0.666

High

936914

TEBP
Prostaglandin E synthase 3

3

3

Small-scale

0.660

High

840026

CASP3
Caspase-3

1

18

Small-scale

0.647

High

840100

CASP2
Caspase-2

1

20

Small-scale

0.647

High

936924

CASPA
Caspase-10

1

19

Small-scale

0.647

High

936925

BIRC7
Baculoviral IAP repeat-containing protein 7

1

20

Small-scale

0.647

High

639592

SAT1
Diamine acetyltransferase 1

3

0

High-throughput

0.646

High

936932

FBW1B
F-box/WD repeat-containing protein 11

2

4

High-throughput

0.611

High

848852

MAGAB
Melanoma-associated antigen 11

2

1

High-throughput

0.606

High

442647

RB
Retinoblastoma-associated protein

2

5

Small-scale

0.602

High

936926

PANX1
Pannexin-1

2

2

Small-scale

0.595

High

912530

GDIR1
Rho GDP-dissociation inhibitor 1

2

8

Small-scale

0.585

High

384645

CRYAB
Alpha-crystallin B chain

2

10

Small-scale

0.584

High

534837

BIP
Endoplasmic reticulum chaperone BiP

2

6

Small-scale

0.584

High

936916

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

Small-scale

0.582

High

936928

NIF3L
NIF3-like protein 1

2

0

High-throughput

0.580

High

936903

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.579

High

936906

PAK2
Serine/threonine-protein kinase PAK 2

1

6

Small-scale

0.554

High

928394

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.552

High

936901

TCPB
T-complex protein 1 subunit beta

1

0

Small-scale

0.537

High

604397

ASM
Sphingomyelin phosphodiesterase

1

1

Small-scale

0.536

High

936905

TRAF2
TNF receptor-associated factor 2

1

20

High-throughput

0.536

High

936933

FBW1A
F-box/WD repeat-containing protein 1A

1

4

High-throughput

0.536

High

912622

GDIR2
Rho GDP-dissociation inhibitor 2

1

8

Small-scale

0.516

High

699664

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

5

High-throughput

0.515

High

843420

HD
Huntingtin

1

4

High-throughput

0.515

High

936920

SKAP1
Src kinase-associated phosphoprotein 1

1

2

High-throughput

0.515

High

936917

C2D1B
Coiled-coil and C2 domain-containing protein 1B

1

0

High-throughput

0.513

High

936922

SLAI1
SLAIN motif-containing protein 1

1

0

High-throughput

0.513

High

130833

DFFA
DNA fragmentation factor subunit alpha

1

3

Small-scale

0.501

High

464887

SP1
Transcription factor Sp1

1

2

Small-scale

0.501

High

474580

VIME
Vimentin

1

5

Small-scale

0.501

High

505863

PA24B
Cytosolic phospholipase A2 beta

1

7

Small-scale

0.501

High

529432

TAU
Microtubule-associated protein tau

1

7

Small-scale

0.501

High

622561

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

16

Small-scale

0.501

High

838033

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

2

Small-scale

0.501

High

936908

ROCK1
Rho-associated protein kinase 1

1

4

Small-scale

0.501

High

936911

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

2

Small-scale

0.501

High

936919

CSN6
COP9 signalosome complex subunit 6

1

5

Small-scale

0.501

High

936929

CLSPN
Claspin

1

3

Small-scale

0.501

High

936907

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.493

High

866457

PA24A
Cytosolic phospholipase A2

1

7

Small-scale

0.484

High

413487

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

612951

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

926903

ATX3
Ataxin-3

1

2

High-throughput

0.479

High

934329

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

936912

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

4

High-throughput

0.479

High

936915

NEDD8
Ubiquitin-like protein NEDD8

1

2

Small-scale

0.479

High

936918

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

936931

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

936921

KLH36
Kelch-like protein 36

1

3

High-throughput

0.470

High

330093

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.445

High

344436

IL33
Interleukin-33

1

2

Small-scale

0.445

High

363041

EGFR
Epidermal growth factor receptor

1

6

Small-scale

0.445

High

469783

CATG
Cathepsin G

1

11

Small-scale

0.445

High

936900

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

3

High-throughput

0.445

High

936902

NUCB2
Nucleobindin-2

1

5

Small-scale

0.445

High

936923

HDAC7
Histone deacetylase 7

1

6

Small-scale

0.445

High

936927

ZN747
Zinc finger protein 747

1

3

High-throughput

0.407

High


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Last updated: 11Aug2025