Protein: CASPE
Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]

Gene: CASPE, CASP14
Organism: Homo sapiens
Interactions: 166
UniProt ID: P31944

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0004197 - cysteine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

413276

P53
Cellular tumor antigen p53

3

5

Small-scale

0.640

High

729565

ZIC1
Zinc finger protein ZIC 1

2

1

High-throughput

0.628

High

563287

CFTR
Cystic fibrosis transmembrane conductance regulator

3

3

Small-scale

0.624

High

712830

CASP1
Caspase-1

1

17

Small-scale

0.618

High

729521

CASP2
Caspase-2

1

17

Small-scale

0.618

High

729525

CASP4
Caspase-4

1

18

Small-scale

0.618

High

729559

CASP8
Caspase-8

1

17

Small-scale

0.618

High

729597

CASPA
Caspase-10

1

17

Small-scale

0.618

High

391574

FRIH
Ferritin heavy chain

2

0

High-throughput

0.602

High

729632

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.602

High

729520

CCNF
Cyclin-F

2

1

High-throughput

0.601

High

722771

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

2

0

Small-scale

0.585

High

371286

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.584

High

729627

ZRAN1
Ubiquitin thioesterase ZRANB1

2

10

High-throughput

0.584

High

729623

TB22B
TBC1 domain family member 22B

2

1

High-throughput

0.574

High

729528

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.573

High

635566

FILA
Filaggrin

2

4

Small-scale

0.571

High

729567

RHG29
Rho GTPase-activating protein 29

2

1

High-throughput

0.571

High

729591

ARH40
Rho guanine nucleotide exchange factor 40

2

2

High-throughput

0.571

High

282676

E2F6
Transcription factor E2F6

1

1

High-throughput

0.536

High

552138

ADT3
ADP/ATP translocase 3

1

2

High-throughput

0.536

High

622768

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

5

High-throughput

0.536

High

625214

CSK22
Casein kinase II subunit alpha'

1

4

High-throughput

0.536

High

666802

CCNC
Cyclin-C

1

2

High-throughput

0.536

High

729523

MSH2
DNA mismatch repair protein Msh2

1

1

High-throughput

0.536

High

729527

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.536

High

729529

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

4

High-throughput

0.536

High

729549

ZN154
Zinc finger protein 154

1

1

High-throughput

0.536

High

729550

CUL2
Cullin-2

1

5

High-throughput

0.536

High

729575

JADE1
Protein Jade-1

1

2

High-throughput

0.536

High

729580

ZN550
Zinc finger protein 550

1

2

High-throughput

0.536

High

729581

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

1

High-throughput

0.536

High

729590

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

1

High-throughput

0.536

High

729617

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.536

High

729633

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

3

High-throughput

0.536

High

226936

LIAS
Lipoyl synthase, mitochondrial

1

0

High-throughput

0.513

High

231207

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

0

High-throughput

0.513

High

602748

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

729517

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.513

High

729532

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

729533

DSCR6
Protein ripply3

1

0

High-throughput

0.513

High

729539

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

729555

TF2H3
General transcription factor IIH subunit 3

1

0

High-throughput

0.513

High

729561

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.513

High

729579

APTX
Aprataxin

1

0

High-throughput

0.513

High

729585

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.513

High

729586

COA5
Cytochrome c oxidase assembly factor 5

1

0

High-throughput

0.513

High

729587

AROS
Active regulator of SIRT1

1

0

High-throughput

0.513

High

729592

SETD7
Histone-lysine N-methyltransferase SETD7

1

0

High-throughput

0.513

High

729598

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

0

High-throughput

0.513

High

729602

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.513

High

729603

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.513

High

729604

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.513

High

729606

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.513

High

729616

COE2
Transcription factor COE2

1

0

High-throughput

0.513

High

729621

TSSP
Thymus-specific serine protease

1

0

High-throughput

0.513

High

729630

PHF8
Histone lysine demethylase PHF8

1

0

High-throughput

0.513

High

729535

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.501

High

729635

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

1

Small-scale

0.501

High

222357

TSN6
Tetraspanin-6

1

1

High-throughput

0.489

High

729558

GPR18
N-arachidonyl glycine receptor

1

1

High-throughput

0.489

High

141336

DDX3X
ATP-dependent RNA helicase DDX3X

1

2

Small-scale

0.479

High

174223

ARHGA
Rho guanine nucleotide exchange factor 10

1

1

High-throughput

0.479

High

240872

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

302396

RNF8
E3 ubiquitin-protein ligase RNF8

1

5

High-throughput

0.479

High

395575

ESR1
Estrogen receptor

1

5

High-throughput

0.479

High

405834

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.479

High

424144

S10A8
Protein S100-A8

1

4

High-throughput

0.479

High

444911

S10A9
Protein S100-A9

1

5

High-throughput

0.479

High

456198

CATD
Cathepsin D

1

1

High-throughput

0.479

High

456630

ANXA2
Annexin A2

1

1

High-throughput

0.479

High

457839

INVO
Involucrin

1

1

High-throughput

0.479

High

536597

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

577637

PLAK
Junction plakoglobin

1

2

High-throughput

0.479

High

587569

DESP
Desmoplakin

1

5

High-throughput

0.479

High

623135

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

High-throughput

0.479

High

713332

SPB3
Serpin B3

1

8

High-throughput

0.479

High

724534

S10A7
Protein S100-A7

1

5

High-throughput

0.479

High

729516

1433S
14-3-3 protein sigma

1

4

High-throughput

0.479

High

729518

SPB5
Serpin B5

1

8

High-throughput

0.479

High

729536

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

729537

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

729538

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

729540

DSG1
Desmoglein-1

1

3

High-throughput

0.479

High

729542

SOX4
Transcription factor SOX-4

1

2

High-throughput

0.479

High

729543

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

2

High-throughput

0.479

High

729545

DSC1
Desmocollin-1

1

2

High-throughput

0.479

High

729547

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

4

High-throughput

0.479

High

729551

CUL4A
Cullin-4A

1

5

High-throughput

0.479

High

729552

PKP1
Plakophilin-1

1

4

High-throughput

0.479

High

729553

DX39B
Spliceosome RNA helicase DDX39B

1

3

High-throughput

0.479

High

729554

BLMH
Bleomycin hydrolase

1

1

High-throughput

0.479

High

729557

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

6

High-throughput

0.479

High

729560

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

High-throughput

0.479

High

729562

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

729564

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

729568

FILA2
Filaggrin-2

1

4

High-throughput

0.479

High

729588

MET23
Histone-arginine methyltransferase METTL23

1

1

High-throughput

0.479

High

729595

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

20

High-throughput

0.479

High

729596

RBP56
TATA-binding protein-associated factor 2N

1

1

High-throughput

0.479

High

729601

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

729605

SPB12
Serpin B12

1

8

High-throughput

0.479

High

729608

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.479

High

729609

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

729611

DDX24
ATP-dependent RNA helicase DDX24

1

6

High-throughput

0.479

High

729612

PRD14
PR domain zinc finger protein 14

1

3

Small-scale

0.479

High

729613

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

3

Small-scale

0.479

High

729615

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

729620

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

729622

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

1

2

High-throughput

0.479

High

729631

FBW1A
F-box/WD repeat-containing protein 1A

1

4

High-throughput

0.479

High

729634

LOXL2
Lysyl oxidase homolog 2

1

2

High-throughput

0.479

High

293273

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

423612

ARGI1
Arginase-1

1

0

High-throughput

0.458

High

587422

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.458

High

649760

SPR2E
Small proline-rich protein 2E

1

0

High-throughput

0.458

High

671760

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.458

High

729526

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

729541

K1C17
Keratin, type I cytoskeletal 17

1

0

High-throughput

0.458

High

729563

CDSN
Corneodesmosin

1

0

High-throughput

0.458

High

729569

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

729570

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.458

High

729571

KPLCE
Protein KPLCE

1

0

High-throughput

0.458

High

729572

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

729574

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

729576

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

729583

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

729599

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

Small-scale

0.458

High

729614

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

729625

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

729626

CALL5
Calmodulin-like protein 5

1

0

High-throughput

0.458

High

729628

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

729629

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

529192

TAU
Microtubule-associated protein tau

1

7

Small-scale

0.445

High

729530

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.445

High

729534

CD81
CD81 antigen

1

1

Small-scale

0.445

High

729548

IFT88
Intraflagellar transport protein 88 homolog

1

2

High-throughput

0.445

High

729619

ISK5
Serine protease inhibitor Kazal-type 5

1

3

Small-scale

0.445

High

213396

ZSC12
Zinc finger and SCAN domain-containing protein 12

1

0

High-throughput

0.426

High

729522

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.426

High

729546

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.426

High

729556

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

729544

LG3BP
Galectin-3-binding protein

1

4

High-throughput

0.407

High

292566

RENR
Renin receptor

1

0

High-throughput

0.279

Low

325294

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

420244

IFNA4
Interferon alpha-4

1

0

High-throughput

0.279

Low

729524

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

729531

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

0

High-throughput

0.279

Low

729566

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

729577

AMTN
Amelotin

1

0

High-throughput

0.279

Low

729578

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

High-throughput

0.279

Low

729582

SO6A1
Solute carrier organic anion transporter family member 6A1

1

0

High-throughput

0.279

Low

729584

MOGT3
2-acylglycerol O-acyltransferase 3

1

0

High-throughput

0.279

Low

729594

ITLN2
Intelectin-2

1

0

High-throughput

0.279

Low

729600

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

729607

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

729618

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

0

High-throughput

0.279

Low

389080

FINC
Fibronectin

1

0

Small-scale

0.249

Low

458669

SAP
Prosaposin

1

0

Small-scale

0.249

Low

729519

ACVL1
Activin receptor type-1-like

1

0

Small-scale

0.249

Low

729593

POF1B
Protein POF1B

1

0

High-throughput

0.249

Low

729610

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

729624

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

87347

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

729573

RNLS
Renalase

1

0

Small-scale

0.232

Low

729589

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025