Protein: CASP2
Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]

Gene: CASP2
Organism: Homo sapiens
Interactions: 47
UniProt ID: P42575

Gene Ontology (top 5):
GO:0001554 - luteolysis
GO:0003407 - neural retina development
GO:0004197 - cysteine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

840108

CRADD
Death domain-containing protein CRADD

12

2

Small-scale

0.985

High

840099

CASP2
Caspase-2

10

20

Small-scale

0.974

High

840126

PIDD1
p53-induced death domain-containing protein 1

5

4

Small-scale

0.912

High

840013

CASP3
Caspase-3

2

17

Small-scale

0.778

High

840115

CASP8
Caspase-8

2

20

Small-scale

0.778

High

840113

BIRC2
Baculoviral IAP repeat-containing protein 2

2

20

Small-scale

0.768

High

840109

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.710

High

158410

RFXK
DNA-binding protein RFXANK

1

0

Small-scale

0.676

High

840100

CASP7
Caspase-7

1

20

Small-scale

0.647

High

840120

CASPA
Caspase-10

1

20

Small-scale

0.647

High

298256

BODG
Gamma-butyrobetaine dioxygenase

3

0

High-throughput

0.638

High

840125

EPN3
Epsin-3

3

0

High-throughput

0.638

High

262151

NOL3
Nucleolar protein 3

1

2

Small-scale

0.618

High

622544

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

17

Small-scale

0.618

High

729521

CASPE
Caspase-14

1

17

Small-scale

0.618

High

840124

NLRP1
NACHT, LRR and PYD domains-containing protein 1

1

20

Small-scale

0.618

High

840128

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

20

Small-scale

0.618

High

225544

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

3

High-throughput

0.606

High

840101

BID
BH3-interacting domain death agonist

2

4

Small-scale

0.602

High

840102

HNRPK
Heterogeneous nuclear ribonucleoprotein K

2

0

High-throughput

0.602

High

336636

BAG4
BAG family molecular chaperone regulator 4

2

0

High-throughput

0.580

High

840123

CIB1
Calcium and integrin-binding protein 1

1

0

Small-scale

0.549

High

334154

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

High-throughput

0.536

High

840122

NPAS1
Neuronal PAS domain-containing protein 1

1

3

High-throughput

0.536

High

840103

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.518

High

840118

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

625777

RXRA
Retinoic acid receptor RXR-alpha

1

3

High-throughput

0.508

High

840104

GRB2
Growth factor receptor-bound protein 2

1

2

High-throughput

0.508

High

840107

EF1A1
Elongation factor 1-alpha 1

1

2

High-throughput

0.508

High

840117

RAI1
Retinoic acid-induced protein 1

1

6

High-throughput

0.508

High

529275

TAU
Microtubule-associated protein tau

1

7

Small-scale

0.501

High

840106

UBC9
SUMO-conjugating enzyme UBC9

1

1

Small-scale

0.481

High

216640

HTRA2
Serine protease HTRA2, mitochondrial

1

2

Small-scale

0.479

High

384637

CRYAB
Alpha-crystallin B chain

1

11

Small-scale

0.479

High

840110

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

840111

TRAF1
TNF receptor-associated factor 1

1

18

Small-scale

0.479

High

840112

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.479

High

840114

CUL3
Cullin-3

1

5

High-throughput

0.479

High

840116

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

840119

KAT6A
Histone acetyltransferase KAT6A

1

6

Small-scale

0.479

High

840127

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

1

2

High-throughput

0.479

High

718869

CCND3
G1/S-specific cyclin-D3

1

0

Small-scale

0.460

High

840105

SUMO1
Small ubiquitin-related modifier 1

1

0

Small-scale

0.460

High

840121

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

72293

A9IYQ1
PDS5 cohesin associated factor B

1

2

High-throughput

0.437

High

767605

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High


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Last updated: 11Aug2025