HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: MRP8 (Q96J66)
ATP-binding cassette sub-family C member 11 (EC 7.6.2.2) (EC 7.6.2.3) (Multidrug resistance-associated protein 8)
Gene: ABCC11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

The method score is based on:

Property	Details
Experiments	26618866, 35156780
Identification Methods	affinity chromatography technology, protein complementation assay, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	ABC_membrane~ABC_membrane, ABC_membrane~ABC_tran, ABC_tran~ABC_tran, ABC_membrane~CFTR_R, ABC_tran~CFTR_R
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016020 - membrane GO:0016324 - apical plasma membrane GO:0016887 - ATP hydrolysis activity and 3 others more... GO:0042626 - ATPase-coupled transmembrane transporter activity GO:0043225 - ATPase-coupled inorganic anion transmembrane transporter activity GO:0055085 - transmembrane transport
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	1480
Hs

1	1382

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Last updated: 15 Jul 2024