HitPredict

Interactor 1: KAP0 (P10644)
cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)
Gene: PRKAR1A

Interactor 2: KPCA (P17252)
Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Gene: PRKCA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31980649, 36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~cNMP_binding, Pkinase~RIIa
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032024 - positive regulation of insulin secretion GO:0035556 - intracellular signal transduction
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 381 Hs			1 672
+	Hs
		603178 KAP1_HUMAN (1-381): 2.75e-134: 390: 81.37		KPCA_HUMAN (1-672): 0: 802: 100.00
+	Mm
		556494 KAP1_MOUSE (1-381): 4.66e-138: 400: 81.37		KPCB_MOUSE (1-664): 0: 752: 79.34
+	Hs
		436593 KAP0_HUMAN (1-381): 7.43e-136: 394: 100.00		KPCB_HUMAN (1-664): 0: 754: 78.89
+	Mm
		556492 KAP1_MOUSE (1-381): 4.66e-138: 400: 81.37		KPCG_MOUSE (16-670): 0: 706: 69.88
+	Hs
		603179 KAP3_HUMAN (10-256): 3.92e-21: 95.9: 18.38		KPCA_HUMAN (1-672): 0: 802: 100.00
+	Hs
		568750 KAP2_HUMAN (233-381): 3.89e-17: 84.3: 26.80		KPCA_HUMAN (1-672): 0: 802: 100.00
+	Hs
		254785 HCN1_HUMAN (233-359): 2.68e-14: 76.6: 24.24		KPCA_HUMAN (1-672): 0: 802: 100.00
+	Hs
		531008 KAP0_HUMAN (1-381): 7.43e-136: 394: 100.00		AKT1_HUMAN (245-660): 4.41e-157: 463: 37.53
+	Hs
		531013 KAP0_HUMAN (1-381): 7.43e-136: 394: 100.00		KPCI_HUMAN (22-86): 8.67e-12: 70.1: 43.08
+	Hs
		531049 KAP0_HUMAN (1-381): 7.43e-136: 394: 100.00		KPCZ_HUMAN (22-98): 3.22e-11: 68.6: 34.44