Protein: HTF4
Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)

Gene: HTF4, TCF12
Organism: Homo sapiens
Interactions: 140
UniProt ID: Q99081

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1303333

NGN3
Neurogenin-3

7

20

High-throughput

0.972

High

568226

TAL1
T-cell acute lymphocytic leukemia protein 1

7

20

Small-scale

0.963

High

970599

ID2
DNA-binding protein inhibitor ID-2

7

20

Small-scale

0.962

High

971137

ID3
DNA-binding protein inhibitor ID-3

7

20

Small-scale

0.962

High

780982

ID1
DNA-binding protein inhibitor ID-1

6

20

Small-scale

0.941

High

1167653

ASCL4
Achaete-scute homolog 4

5

20

Small-scale

0.933

High

1261463

TWST2
Twist-related protein 2

5

20

High-throughput

0.933

High

1039378

NDF1
Neurogenic differentiation factor 1

5

20

High-throughput

0.926

High

1186211

TCF23
Transcription factor 23

4

20

Small-scale

0.895

High

616615

MYF6
Myogenic factor 6

3

20

High-throughput

0.870

High

210863

TCF21
Transcription factor 21

3

20

Small-scale

0.864

High

1300900

FER3L
Fer3-like protein

3

19

High-throughput

0.863

High

546105

MYOG
Myogenin

3

20

High-throughput

0.861

High

551256

ITF2
Transcription factor 4

3

13

High-throughput

0.861

High

1012646

MESP2
Mesoderm posterior protein 2

3

6

High-throughput

0.861

High

63055

MSGN1
Mesogenin-1

3

20

High-throughput

0.858

High

238594

MUSC
Musculin

3

20

High-throughput

0.858

High

899129

HAND2
Heart- and neural crest derivatives-expressed protein 2

3

20

High-throughput

0.858

High

971838

HEN2
Helix-loop-helix protein 2

3

20

High-throughput

0.858

High

1163321

FIGLA
Factor in the germline alpha

3

20

High-throughput

0.858

High

1272169

NGN1
Neurogenin-1

3

20

High-throughput

0.858

High

1303322

ASCL3
Achaete-scute homolog 3

3

20

High-throughput

0.858

High

1083176

TAL2
T-cell acute lymphocytic leukemia protein 2

2

20

High-throughput

0.817

High

347672

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.789

High

330430

HAND1
Heart- and neural crest derivatives-expressed protein 1

2

20

High-throughput

0.783

High

1297882

HEXI2
Protein HEXIM2

6

1

High-throughput

0.741

High

987459

MTG8
Protein CBFA2T1

4

9

Small-scale

0.699

High

546034

MYOD1
Myoblast determination protein 1

1

20

High-throughput

0.691

High

840637

ASCL1
Achaete-scute homolog 1

1

20

High-throughput

0.691

High

971805

HEN1
Helix-loop-helix protein 1

1

20

High-throughput

0.691

High

1018388

TCF15
Transcription factor 15

1

20

High-throughput

0.691

High

1076858

TWST1
Twist-related protein 1

1

20

High-throughput

0.691

High

1303321

NDF4
Neurogenic differentiation factor 4

1

20

High-throughput

0.691

High

790998

CDN2C
Cyclin-dependent kinase 4 inhibitor C

3

2

High-throughput

0.683

High

1168488

TRI72
Tripartite motif-containing protein 72

3

2

High-throughput

0.675

High

1242407

MORN4
MORN repeat-containing protein 4

3

1

High-throughput

0.675

High

1290285

SGF29
SAGA-associated factor 29

3

1

High-throughput

0.667

High

551571

TFE2
Transcription factor E2-alpha

1

13

Small-scale

0.665

High

1303316

HTF4
Transcription factor 12

1

13

Small-scale

0.647

High

1303317

TSNAX
Translin-associated protein X

3

0

High-throughput

0.646

High

637526

PSA1
Proteasome subunit alpha type-1

2

1

High-throughput

0.628

High

1303325

SPG21
Maspardin

2

1

High-throughput

0.628

High

1303328

OSGI1
Oxidative stress-induced growth inhibitor 1

2

1

High-throughput

0.628

High

1186216

OLIG3
Oligodendrocyte transcription factor 3

1

20

Small-scale

0.621

High

379762

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.618

High

814913

ID4
DNA-binding protein inhibitor ID-4

1

20

Small-scale

0.618

High

1271845

ATOH1
Transcription factor ATOH1

1

20

Small-scale

0.618

High

1303329

VPS28
Vacuolar protein sorting-associated protein 28 homolog

2

3

High-throughput

0.613

High

254000

MTG16
Protein CBFA2T3

2

9

Small-scale

0.611

High

212497

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

1

High-throughput

0.606

High

640597

DDX6
Probable ATP-dependent RNA helicase DDX6

2

4

High-throughput

0.606

High

895450

CKS1
Cyclin-dependent kinases regulatory subunit 1

2

1

High-throughput

0.606

High

1002063

ARL16
ADP-ribosylation factor-like protein 16

2

1

High-throughput

0.606

High

1038032

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

1

High-throughput

0.606

High

1062780

FL2D
Pre-mRNA-splicing regulator WTAP

2

1

High-throughput

0.606

High

1252424

LNX1
E3 ubiquitin-protein ligase LNX

2

1

High-throughput

0.606

High

1303320

NEK6
Serine/threonine-protein kinase Nek6

2

3

High-throughput

0.606

High

1303334

RBM8A
RNA-binding protein 8A

2

1

High-throughput

0.606

High

814515

SYQ
Glutamine--tRNA ligase

2

0

High-throughput

0.601

High

999004

EP300
Histone acetyltransferase p300

2

9

Small-scale

0.595

High

1294663

NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

2

0

High-throughput

0.580

High

231832

MABP1
Mitogen-activated protein kinase-binding protein 1

1

1

High-throughput

0.573

High

274285

STK16
Serine/threonine-protein kinase 16

1

1

High-throughput

0.573

High

675325

SORCN
Sorcin

1

1

High-throughput

0.573

High

1216816

ARMC8
Armadillo repeat-containing protein 8

1

1

High-throughput

0.573

High

1303324

AIRIM
AFG2-interacting ribosome maturation factor

1

1

High-throughput

0.573

High

850447

CLCKA
Chloride channel protein ClC-Ka

2

1

High-throughput

0.553

High

1223251

EXOC8
Exocyst complex component 8

2

1

High-throughput

0.553

High

270211

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.549

High

786630

STA5A
Signal transducer and activator of transcription 5A

1

0

High-throughput

0.549

High

1107834

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.549

High

1301911

LYSM1
LysM and putative peptidoglycan-binding domain-containing protein 1

1

0

High-throughput

0.549

High

1303318

HOP
Homeodomain-only protein

1

0

High-throughput

0.549

High

818384

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.536

High

1022858

STRN3
Striatin-3

1

6

High-throughput

0.536

High

1303323

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.536

High

1303331

TRI33
E3 ubiquitin-protein ligase TRIM33

1

7

Small-scale

0.536

High

206413

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.518

High

304551

PRS23
Serine protease 23

1

0

High-throughput

0.518

High

270829

FOXH1
Forkhead box protein H1

1

2

Small-scale

0.515

High

950259

SMAD3
Mothers against decapentaplegic homolog 3

1

2

Small-scale

0.515

High

851223

CCNH
Cyclin-H

1

1

High-throughput

0.515

High

1158891

Q6P2C6
MLLT6 protein

1

8

High-throughput

0.515

High

1205203

CD20B
Cell division cycle protein 20 homolog B

1

1

High-throughput

0.515

High

1282752

GTPB3
tRNA modification GTPase GTPBP3, mitochondrial

1

1

High-throughput

0.515

High

1295638

MY15B
Unconventional myosin-XVB

1

3

High-throughput

0.515

High

1303330

TTF2
Transcription termination factor 2

1

6

High-throughput

0.515

High

308009

ZWINT
ZW10 interactor

1

0

High-throughput

0.513

High

804327

NOTC1
Neurogenic locus notch homolog protein 1

1

0

High-throughput

0.513

High

124250

TAF4
Transcription initiation factor TFIID subunit 4

1

1

Small-scale

0.501

High

261573

NCOR1
Nuclear receptor corepressor 1

1

2

Small-scale

0.501

High

1270770

CBP
CREB-binding protein

1

10

Small-scale

0.501

High

1303332

FA50B
Protein FAM50B

1

0

High-throughput

0.493

High

473708

ZN688
Zinc finger protein 688

1

5

High-throughput

0.481

High

876617

AF17
Protein AF-17

1

7

High-throughput

0.481

High

984831

RN5A
2-5A-dependent ribonuclease

1

1

High-throughput

0.481

High

1048715

DGCR6
Protein DGCR6

1

3

High-throughput

0.481

High

1298642

FRMD6
FERM domain-containing protein 6

1

1

High-throughput

0.481

High

589913

TBP
TATA-box-binding protein

1

0

Small-scale

0.480

High

163176

XPO1
Exportin-1

1

2

High-throughput

0.479

High

301989

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.479

High

319311

BRD1
Bromodomain-containing protein 1

1

10

High-throughput

0.479

High

600212

TAF1
Transcription initiation factor TFIID subunit 1

1

13

High-throughput

0.479

High

617360

SP100
Nuclear autoantigen Sp-100

1

6

High-throughput

0.479

High

668928

PML
Protein PML

1

6

High-throughput

0.479

High

798985

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.479

High

830779

ARL4D
ADP-ribosylation factor-like protein 4D

1

1

High-throughput

0.479

High

831620

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.479

High

964408

RUNX1
Runt-related transcription factor 1

1

1

Small-scale

0.479

High

980851

TLE3
Transducin-like enhancer protein 3

1

8

High-throughput

0.479

High

1019100

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1035277

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

1

High-throughput

0.479

High

1078638

SMAD2
Mothers against decapentaplegic homolog 2

1

2

Small-scale

0.479

High

1191141

I2BP2
Interferon regulatory factor 2-binding protein 2

1

2

Small-scale

0.479

High

1222535

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.479

High

1246152

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.479

High

1262803

PHIP
PH-interacting protein

1

1

High-throughput

0.479

High

1273818

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

Small-scale

0.479

High

1303319

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

171326

EPHB6
Ephrin type-B receptor 6

1

1

High-throughput

0.470

High

1093428

Q1RLL8
Ribonuclease L

1

1

High-throughput

0.470

High

1122105

Q548N1
Vacuolar protein sorting-associated protein 28 homolog

1

3

High-throughput

0.470

High

1262019

Q8WVZ3
MORN repeat containing 4

1

2

High-throughput

0.470

High

1047457

PEBB
Core-binding factor subunit beta

1

0

High-throughput

0.458

High

1188761

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1288259

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

1303326

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

385395

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

3494

A0A0S2Z6P0
Zinc finger protein 688 isoform 2

1

4

High-throughput

0.417

High

1303335

X5DP20
DiGeorge syndrome critical region 6 isoform D

1

3

High-throughput

0.417

High

1054085

GRB7
Growth factor receptor-bound protein 7

2

0

High-throughput

0.316

High

1223745

TBC21
TBC1 domain family member 21

2

0

High-throughput

0.316

High

1223473

CF206
Cilia- and flagella-associated protein 206

1

0

High-throughput

0.299

High

1297742

MERB1
bMERB domain-containing protein 1

1

0

High-throughput

0.299

High

1303327

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.299

High

1297094

BMF
Bcl-2-modifying factor

1

0

High-throughput

0.282

High

155853

SH21B
SH2 domain-containing protein 1B

1

0

High-throughput

0.268

Low

1061989

T132D
Transmembrane protein 132D

1

0

Small-scale

0.251

Low

81755

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024